Results 81 to 90 of about 2,110,017 (419)

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

ADAR enzyme and miRNA story: A nucleotide that can make the difference [PDF]

, 2013
Adenosine deaminase acting on RNA (ADAR) enzymes convert adenosine (A) to inosine (I) in double-stranded (ds) RNAs. Since Inosine is read as Guanosine, the biological consequence of ADAR enzyme activity is an A/G conversion within RNA molecules.
Alisi, A, Bonamassa, B, Gallo, A., Locatelli, F, Nobili, V, Tomaselli, S   +5 more
core   +2 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Differential Binding of Mitochondrial Transcripts by MRB8170 and MRB4160 Regulates Distinct Editing Fates of Mitochondrial mRNA in Trypanosomes

mBio, 2017
A dozen mRNAs are edited by multiple insertions and/or deletions of uridine residues in the mitochondrion of Trypanosoma brucei. Several protein complexes have been implicated in performing this type of RNA editing, including the mitochondrial RNA ...
Sameer Dixit, Michaela Müller-McNicoll, Vojtěch David, Kathi Zarnack, Jernej Ule, Hassan Hashimi, Julius Lukeš   +6 more
doaj   +1 more source

Analysis and minimization of cellular RNA editing by DNA adenine base editors

Science Advances, 2019
We report cellular RNA editing by adenine base editors and new ABE variants with reduced RNA editing activity. Adenine base editors (ABEs) enable precise and efficient conversion of target A•T base pairs to G•C base pairs in genomic DNA with a minimum of
H. Rees, Christopher Wilson, Jordan L. Doman, David R. Liu   +3 more
semanticscholar   +1 more source

A structural determinant required for RNA editing [PDF]

, 2011
RNA editing by adenosine deaminases acting on RNAs (ADARs) can be both specific and non-specific, depending on the substrate. Specific editing of particular adenosines may depend on the overall sequence and structural context.
Aruscavage, Athanasiadis, Bass, Bernstein, Cao, Christina Waldsich, Dawson, Dominik Muggenhumer, Enstero, Hallegger, Hartner, Heale, Herbert, Higuchi, Hoopengardner, Iizasa, Jingpei Bi, Knight, Lehmann, Li, Liebeg, Linnstaedt, Maas, Macbeth, Michael F. Jantsch, Nan Tian, Nimmich, Nishikura, Nishikura, Nora Sachsenmaier, Ohlson, Palladino, Reenan, Rula, Ryter, Scadden, Stefl, Stefl, Tian, Tonkin, Tonkin, Wahlstedt, Wang, Wong, Yang, Yongfeng Jin, Yun Yang, Zuker   +47 more
core   +2 more sources

RNA editing in inflorescences of wild grapevine unveils association to sex and development [PDF]

, 2020
RNA editing challenges the central dogma of molecular biology, by modifying the genetic information at the transcription level. Recent reports, suggesting increased levels of RNA editing in plants, raised questions on the nature and dynamics of such ...
Amâncio, Sara, Coito, João L., Costa, Maria Manuela Ribeiro, Cunha, Jorge, Faísca-Silva, David, Ramos, Miguel J. N., Rocheta, Margarida, Silva, Helena Gomes, Viegas, Wanda   +8 more
core   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Comparative Analysis of Machine Learning Algorithms for Predicting On-Target and Off-Target Effects of CRISPR-Cas13d for gene editing [PDF]

arXiv, 2023
CRISPR-Cas13 is a system that utilizes single stranded RNAs for RNA editing. Prediction of on-target and off-target effects for the CRISPR-Cas13d dependency enables us to design specific single guide RNAs (sgRNAs) that help locate the desired RNA target positions.
arxiv  

ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity

Oncogene, 2020
Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in double-stranded RNA. A-to-I editing of RNA is a widespread posttranscriptional process that has recently emerged as an important mechanism in cancer biology. A-to-I editing levels
Julia Ramírez-Moya, A. Baker, F. Slack, P. Santisteban   +3 more
semanticscholar   +1 more source