Nascent RNA Folding and RNP Assembly Revealed by Single-molecule Microscopy. [PDF]
J Mol BiolBustamante A +3 more
europepmc +1 more source
Editor's Note on 'Influence of correct secondary and tertiary RNA folding on the binding of cellular factors to the HCV IRES'. [PDF]
Nucleic Acids Res, 2023 europepmc +1 more source
Functional Roles of Chelated Magnesium Ions in RNA Folding and Function. [PDF]
Biochemistry, 2021 Yamagami R, Sieg JP, Bevilacqua PC.
europepmc +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Kinetic Traps in RNA Folding: Targeted Design of Frameshifting Element Mutants by Thermodynamic and Kinetic Analysis of the Chikungunya Virus. [PDF]
J Phys Chem BLee S, Schlick T.
europepmc +1 more source
Expression of concern on 'Influence of correct secondary and tertiary RNA folding on the binding of cellular factors to the HCV IRES'. [PDF]
Nucleic Acids Res, 2023 europepmc +1 more source
FEBS Open Bio, EarlyView.Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada +7 more
wiley +1 more source
Web-based platform for analysis of RNA folding from high throughput chemical probing data. [PDF]
Nucleic Acids Res, 2022 Jurich CP +3 more
europepmc +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
All-at-once RNA folding with 3D motif prediction framed by evolutionary information. [PDF]
Nat MethodsKaran A, Rivas E.
europepmc +1 more source