Results 181 to 190 of about 247,454 (281)

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Single-chain models illustrate the 3D RNA folding shape during translation. [PDF]

Biophys Rep (N Y), 2022
Guo T, Modi OL, Hirano J, Guzman HV, Tsuboi T.   +4 more
europepmc   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Nascent RNA Folding and RNP Assembly Revealed by Single-molecule Microscopy. [PDF]

J Mol Biol
Bustamante A, Carrocci TJ, Nicholson DA, Rodgers ML.   +3 more
europepmc   +1 more source

Editor's Note on 'Influence of correct secondary and tertiary RNA folding on the binding of cellular factors to the HCV IRES'. [PDF]

Nucleic Acids Res, 2023
europepmc   +1 more source

Functional Roles of Chelated Magnesium Ions in RNA Folding and Function. [PDF]

Biochemistry, 2021
Yamagami R, Sieg JP, Bevilacqua PC.
europepmc   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Kinetic Traps in RNA Folding: Targeted Design of Frameshifting Element Mutants by Thermodynamic and Kinetic Analysis of the Chikungunya Virus. [PDF]

J Phys Chem B
Lee S, Schlick T.
europepmc   +1 more source

Expression of concern on 'Influence of correct secondary and tertiary RNA folding on the binding of cellular factors to the HCV IRES'. [PDF]

Nucleic Acids Res, 2023
europepmc   +1 more source

Web-based platform for analysis of RNA folding from high throughput chemical probing data. [PDF]

Nucleic Acids Res, 2022
Jurich CP, Brivanlou A, Rouskin S, Yesselman JD.   +3 more
europepmc   +1 more source