Results 191 to 200 of about 99,329 (307)

RNA helicase DDX5 regulates the translation and genomic replication of foot-and-mouth disease virus. [PDF]

J Virol
Wu J, Abdullah SW, Li P, Wang X, Ren M, Huang Y, Guo X, Sun S, Guo H.   +8 more
europepmc   +1 more source

Synthesis and Evaluation of Aromatic Sulfonamide and Disulfonamide Derivatives as Dengue Virus NS3–NS5 Interaction Inhibitors

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
A synthetic methodology for the preparation of asymmetric benzene‐1,4‐disulfonamides was developed and applied to generate potential anti‐dengue virus (DENV) compounds. Guided by computer‐assisted structural rationalization, we designed synthetically more accessible analogs with reduced toxicity that interact with the DENV NS5 domain, thereby ...
Jakub Janáč, Jan Drahorád, Jakub Harvalík, Tereza Horáčková, Manfred Brinker, Arianna Loregian, Andrea Brancale, Beatrice Mercorelli, Petra Cuřínová   +8 more
wiley   +1 more source

Mitochondrial RNA helicase DDX28 promotes cell cycle and DNA repair programs and shapes an immunosuppressive microenvironment in acute myeloid leukemia. [PDF]

Transl Oncol
Wang Z, Liu Y, Guan X, Ye M, Xu X.
europepmc   +1 more source

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

International Journal of Cancer, Volume 158, Issue 12, Page 3173-3186, 15 June 2026.
What's new? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte, Hossam Eldesouky, Julia Puchan, Sercan Öz, Elena Everatt, Ashish Goyal, Gianluca Sigismondo, Udo Oppermann, Christoph Plass, Dieter Weichenhan, Ali Bakr   +10 more
wiley   +1 more source

RNA helicase DDX3X promotes NK cell survival by supporting MCL1 expression. [PDF]

J Immunol
Mukhopadhyay E, Lakes N, Krishnamurthy D, Tuazon JA, Ohayon DE, Ali A, Seelamneni H, Lee LH, Hildeman DA, Waggoner SN.   +9 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Mechanistic insights into recruitment and regulation of the RNA helicase UPF1 in replication-dependent histone mRNA decay. [PDF]

Nat Commun
Machado de Amorim A, Xue G, He W, Dittmers T, Lewandowski S, Perez-Borrajero C, Bethmann J, Mateva N, Krage C, Nandana V, Loll B, Hilal T, Hennig J, Urlaub H, Marzluff WF, Chakrabarti S.   +15 more
europepmc   +1 more source

RNA Helicase Participates in the Editing Game [PDF]

Neuron, 2000
openaire   +3 more sources

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1268-1275, June 2026.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

The advances of DEAD-box RNA helicase 17 in chronic non-infectious diseases. [PDF]

Front Cardiovasc Med
Xiong M, Wang Q, Wang T, Li M, Deng X, Wang J, Li, Yang Y, Sun X.   +8 more
europepmc   +1 more source