Results 171 to 180 of about 844,014 (252)

RNA helicase DDX5 regulates the translation and genomic replication of foot-and-mouth disease virus. [PDF]

J Virol
Wu J, Abdullah SW, Li P, Wang X, Ren M, Huang Y, Guo X, Sun S, Guo H.   +8 more
europepmc   +1 more source

Comprehensive genomic profiling of mucosal melanoma reveals novel fusion transcripts and dysregulation of cell‐cycle, MAPK, and PI3K pathways

The Journal of Pathology, Volume 270, Issue 3, Page 380-395, November 2026.
Abstract Mucosal melanomas (MMs) are rare, aggressive cancers with poor outcomes and limited response to standard therapies. A significant knowledge gap exists regarding their genomic landscape and corresponding druggable targets. This study explores this issue through a multi‐omic analysis, including whole exome‐, RNA‐, and targeted sequencing, of ...
Matilde Monti, Martina Brigida Romanello, Luca Agnelli, Matteo Orlandi, Luca Bertoli, Sara Picinoli, Irene Pezzali, Giulio Eugenio Mandelli, Daniela Medicina, Giovanni Ribaudo, Adele Busico, Elena Conca, Vilma Pellegrini, Piera Balzarini, Daniele Gallucci, Anna Di Matteo, Davide Lombardi, Claudia Ghigna, Giancarlo Pruneri, Alessandra Gianoncelli, Marzia Rossato, William Vermi   +21 more
wiley   +1 more source

RNA helicase DDX6 governs ASC speck formation in P-bodies and the transition to stress granules via phase separation during inflammasome activation. [PDF]

Cell Discov
Mao R, Liu Y, Fan Z, Li Y, Yang L, Xie Q, Dong HP, Bi M, Gao C, Yang Z, Xu T, Qi X.   +11 more
europepmc   +1 more source

Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Viral proteins represent key vulnerabilities in human coronaviruses (HCoVs). This review outlines inhibitors targeting spike (S), main protease (Mpro), papain‐like protease (PLpro), and RNA‐dependent RNA polymerase (RdRp), mapping chemically diverse strategies that disrupt entry and replication, and provides an integrated view of current candidates ...
Álvaro de la Cruz‐Potenciano, Miguel Maldonado, María‐José Camarasa, Sonia de Castro   +3 more
wiley   +1 more source

RNA Helicase DDX21 Controls CD4⁺ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control. [PDF]

Adv Sci (Weinh)
Zhang Y, Kan C, Yang X, Hao Y, Cai X, Yang M, Zhang Q, Wang Z, Jiang N, Wang L, Li HB, Zhou J.   +11 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, Volume 20, Issue 10, Page 2533-2566, October 2026.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

RNA helicase DDX3X promotes NK cell survival by supporting MCL1 expression. [PDF]

J Immunol
Mukhopadhyay E, Lakes N, Krishnamurthy D, Tuazon JA, Ohayon DE, Ali A, Seelamneni H, Lee LH, Hildeman DA, Waggoner SN.   +9 more
europepmc   +1 more source

Kinetic Control of Condensate Function: How the Formation Dynamics of APBs Influence ALT Cancer Telomere Length Heterogeneity

BioEssays, Volume 48, Issue 10, October 2026.
The dynamics of PML body formation at telomeres in cancer cells using the alternative lengthening of telomeres (ALT) pathway for telomere elongation correlate with different degrees of ALT activity and might contribute to telomere length heterogeneity in ALT cancer cells.
Huaiying Zhang
wiley   +1 more source

Mechanistic insights into recruitment and regulation of the RNA helicase UPF1 in replication-dependent histone mRNA decay. [PDF]

Nat Commun
Machado de Amorim A, Xue G, He W, Dittmers T, Lewandowski S, Perez-Borrajero C, Bethmann J, Mateva N, Krage C, Nandana V, Loll B, Hilal T, Hennig J, Urlaub H, Marzluff WF, Chakrabarti S.   +15 more
europepmc   +1 more source

The Role of Noncoding RNA in MGMT‐Positive Glioblastoma: A Narrative Review

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Glioblastoma (GBM) is the most aggressive primary malignant tumor of the central nervous system and is characterized by rapid progression, frequent recurrence, and poor survival outcomes. The current standard of care, comprising maximal safe surgical resection followed by radiotherapy with concomitant and adjuvant temozolomide (TMZ), has ...
Junfeng Zhao, Jiaxuan Chen, Yingrui Bai, Ying Li, Yiming Han, Chuankun Han, Yintao Li   +6 more
wiley   +1 more source