Results 141 to 150 of about 125,618 (325)
Pif1 helicase directs eukaryotic Okazaki fragments toward the two-nuclease cleavage pathway for primer removal [PDF]
, 2008 Eukaryotic Okazaki fragment maturation requires complete removal of the initiating RNA primer before ligation occurs. Polymerase delta (Pol delta) extends the upstream Okazaki fragment and displaces the 5' end of the downstream primer into a single ...
Ayyagari +38 more
core +2 more sources
Molecular Nutrition &Food Research, EarlyView.In this study we utilized proteomic profiling to investigate mechanisms linked to the cancer‐inhibitory effect of cranberry proanthocyanidins (CPACs) on reflux‐induced esophageal adenocarcinoma in a rat model. The results indicate that CPAC inhibits cancer through targeting multiple hallmarks of cancer known to be dysregulated in progression to ...
Yun Zhang +7 more
wiley +1 more source
Ribosome reinitiation at leader peptides increases translation of bacterial proteins [PDF]
, 2016 Part 1. RNA secondary structures of 5'-untranslated regions of proteins with the PF00270 and PF00271 domains in Corynebacterium diphtheria, C. glutamicum, and Bifidobacterium animalis. Figure S1.1.
Alexandr V. Seliverstov +3 more
core +5 more sources
Novel Findings in Pediatric and Adolescent Patients With Cancer and a Germline SMARCA4 Variant
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction SMARCA4 is a known susceptibility gene for malignant rhabdoid tumors (MRT) in children and small cell carcinoma of the ovary hypercalcemic type (SCCOHT) in young females and women. Recently, a novel association between germline SMARCA4 variants and predisposition to neuroblastoma was proposed.
Nienke van Engelen +12 more
wiley +1 more source
Encephalomyocarditis virus RNA polymerase preparations, with and without RNA helicase activity [PDF]
, 1991 T. M. Dmitrieva +2 more
openalex +1 more source
Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication. [PDF]
, 2013 Myxoma virus (MYXV)-encoded protein M029 is a member of the poxvirus E3 family of dsRNA-binding proteins that antagonize the cellular interferon signaling pathways.
Chan, Winnie M +4 more
core +1 more source
PROTEOMICS, EarlyView.ABSTRACT Peptidyl‐prolyl isomerase, NIMA‐interacting protein 1‐(Pin1) catalyses the cis–trans interconversion of the inflexible bond between serine or threonine residues and proline at the +1 position (pSer/pThr‐Pro). Although initially discovered as an essential regulator of cell division, Pin1 has since been identified as a regulator of many ...
Scott E. Roffey +5 more
wiley +1 more source
Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction
PROTEOMICS, EarlyView.ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella +6 more
wiley +1 more source
Characterisation of the yeast RNA helicase Prp43 [PDF]
, 2016 RNA helicases have many important roles in cell metabolism and are involved in numerous pathways, e.g. translation, pre-mRNA splicing and biogenesis. Interestingly, an increasing number of RNA helicases have been shown to be required for more than one cellular pathway.
openaire +2 more sources
Case Studies of Orphan Domain Reclassification in ECOD by Expert Curation
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Homology‐based protein domain classification is a powerful tool for gaining biological insights into protein function. This classification process has been significantly enhanced by the availability of experimental structures and high‐accuracy structural models generated by advanced tools such as AlphaFold.
Jimin Pei +3 more
wiley +1 more source