Results 41 to 50 of about 305,789 (330)
Nature Network Boston, 2009 Many sarcomas and leukemias carry nonrandom chromosomal translocations encoding tumor-specific mutant fusion transcription factors that are essential to their molecular pathogenesis. Ewing's sarcoma family tumors (ESFTs) contain a characteristic t(11;22)
Hayriye V. Erkizan +10 more
semanticscholar +1 more source
Conserved motifs in the flavivirus NS3 RNA helicase enzyme
Wiley Interdisciplinary Reviews - RNA, 2021 Flaviviruses are a major health concern because over half of the world population is at risk of infection and there are very few antiviral therapeutics to treat diseases resulting from infection.
Kelly E. Du Pont +2 more
semanticscholar +1 more source
DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stress granule formation. [PDF]
PLoS Pathogens, 2014 RIG-I is a DExD/H-box RNA helicase and functions as a critical cytoplasmic sensor for RNA viruses to initiate antiviral interferon (IFN) responses. Here we demonstrate that another DExD/H-box RNA helicase DHX36 is a key molecule for RIG-I signaling by ...
Ji-Seung Yoo +12 more
doaj +1 more source
mBio, 2023 Coronaviruses (CoVs) encode nonstructural proteins 1–16 (nsps 1–16) which form replicase complexes that mediate viral RNA synthesis. Remdesivir (RDV) is an adenosine nucleoside analog antiviral that inhibits CoV RNA synthesis.
Samantha L. Grimes +12 more
doaj +1 more source
Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1. [PDF]
, 2013 One third of inherited genetic diseases are caused by mRNAs harboring premature termination codons as a result of nonsense mutations. These aberrant mRNAs are degraded by the Nonsense-Mediated mRNA Decay (NMD) pathway.
Bracho, Dina P +11 more
core +1 more source
Roles of the linker region of RNA helicase A in HIV-1 RNA metabolism. [PDF]
PLoS ONE, 2013 RNA helicase A (RHA) promotes multiple steps in HIV-1 production including transcription and translation of viral RNA, annealing of primer tRNA(Lys3) to viral RNA, and elevating the ratio of unspliced to spliced viral RNA.
Li Xing +3 more
doaj +1 more source
m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
Nature Communications, 2019 Dynamic mRNA modification in the form of N6-methyladenosine (m6A) adds considerable richness and sophistication to gene regulation. The m6A mark is asymmetrically distributed along mature mRNAs, with approximately 35% of m6A residues located within the ...
Yuanhui Mao +6 more
semanticscholar +1 more source
The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance RNA helicases play critical roles in multiple biological processes. However, little in vivo data are available because of the lethality of mice completely deficient in RNA helicases.
Yalong Wang +21 more
semanticscholar +1 more source
The DEAD-Box RNA Helicase DDX3 Interacts with NF-κB Subunit p65 and Suppresses p65-Mediated Transcription. [PDF]
PLoS ONE, 2016 RNA helicase family members exhibit diverse cellular functions, including in transcription, pre-mRNA processing, RNA decay, ribosome biogenesis, RNA export and translation.
Nian Xiang +10 more
doaj +1 more source
Structural basis of TFIIH activation for nucleotide excision repair. [PDF]
, 2019 Nucleotide excision repair (NER) is the major DNA repair pathway that removes UV-induced and bulky DNA lesions. There is currently no structure of NER intermediates, which form around the large multisubunit transcription factor IIH (TFIIH).
Chernev, A. +5 more
core +2 more sources