Results 111 to 120 of about 1,270,992 (292)

EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks [PDF]

, 2019
The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism. Here we show that the exosome is necessary for the repair of DNA double-strand breaks (DSBs) in human cells and that RNA clearance is an essential step in homologous ...
Bonath, Franziska, Domingo Prim, Judit, Endara Coll, Martin, Friedländer, Marc R., Huertas Sánchez, Pablo, Jimeno González, Sonia, Prados Carvajal, Rosario, Visa, Neus   +7 more
core   +2 more sources

A Cold Shock-Induced Cyanobacterial RNA Helicase [PDF]

Journal of Bacteriology, 1999
ABSTRACT The ability to modify RNA secondary structure is crucial for numerous cellular processes. We have characterized two RNA helicase genes, crhB and crhC , which are differentially expressed in the cyanobacterium Anabaena sp. strain PCC 7120.
Owttrim, George W., Magee, Wendy C., Yu, Esther, Chamot, Danuta   +3 more
openaire   +3 more sources

Promoter Hypermethylation‐Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5‐Mediated Wnt/β‐Catenin Pathway Activation

Advanced Science, EarlyView.
This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen, Fanli Qu, Long Wang, Qing Shao, Sisi Li, Yang Qin, Dongping Jiang, Senmiao Zhang, Jiangdong Sui, Guanwen Wang, Ningning Zhang, Xiaohua Zeng   +11 more
wiley   +1 more source

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

Advanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei, Yu Zhou, Haitao Sun, Hang Yuan, Xinyu Pei, Jessica D. Hess, Yao Yan, Zunsong Hu, Mian Zhou, Zhaohui Gu, Li Zheng, Xiwei Wu, Binghui Shen   +12 more
wiley   +1 more source

Structural basis of Zika virus helicase in recognizing its substrates

Protein & Cell, 2016
The recent explosive outbreak of Zika virus (ZIKV) infection has been reported in South and Central America and the Caribbean. Neonatal microcephaly associated with ZIKV infection has already caused a public health emergency of international concern.
Hongliang Tian, Xiaoyun Ji, Xiaoyun Yang, Zhongxin Zhang, Zuokun Lu, Kailin Yang, Cheng Chen, Qi Zhao, Heng Chi, Zhongyu Mu, Wei Xie, Zefang Wang, Huiqiang Lou, Haitao Yang, Zihe Rao   +14 more
doaj   +1 more source

Function of Plant DExD/H-Box RNA Helicases Associated with Ribosomal RNA Biogenesis

Frontiers in Plant Science, 2018
Ribosome biogenesis is a highly complex process that requires several cofactors, including DExD/H-box RNA helicases (RHs). RHs are a family of ATPases that rearrange the secondary structures of RNA and thus remodel ribonucleoprotein complexes. DExD/H-box
Yuelin Liu, R. Imai
semanticscholar   +1 more source

A two-state model for helicase translocation and unwinding of nucleic acids [PDF]

, 2008
Helicases are molecular motors that unwind double-stranded nucleic acids (dsNA), such as DNA and RNA). Typically a helicase translocates along one of the NA single strands while unwinding and uses adenosine triphosphate (ATP) hydrolysis as an energy ...
Ashok Garai, B. Alberts, C. L. Tai, D. N. Frick, Debashish Chowdhury, J. Howard, M. D. Betterton, N. David   +7 more
core   +2 more sources

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Genome-wide identification, in silico characterization and expression analysis of the RNA helicase gene family in chickpea (C. arietinum L.)

Scientific Reports, 2022
The RNA helicases are an important class of enzymes which are known to influence almost every aspect of RNA metabolism. The majority of RNA helicases belong to the SF2 (superfamily 2) superfamily, members of which are further categorized into three ...
Sheel Yadav, Yashwant K. Yadava, Deshika Kohli, Shashi Meena, Gopal Kalwan, C. Bharadwaj, Kishor Gaikwad, Ajay Arora, P. K. Jain   +8 more
doaj   +1 more source

Chloroplast- or Mitochondria-Targeted DEAD-Box RNA Helicases Play Essential Roles in Organellar RNA Metabolism and Abiotic Stress Responses

Frontiers in Plant Science, 2017
The yields and productivity of crops are greatly diminished by various abiotic stresses, including drought, cold, heat, and high salinity. Chloroplasts and mitochondria are cellular organelles that can sense diverse environmental stimuli and alter gene ...
Ghazala Nawaz, Hunseung Kang
semanticscholar   +1 more source