Results 161 to 170 of about 768,185 (263)
Compartmentalisation in cAMP signalling: A phase separation perspective
British Journal of Pharmacology, EarlyView.Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley +1 more source
Untangling the roles of RNA helicases in antiviral innate immunity. [PDF]
PLoS Pathog, 2021 Baldaccini M, Pfeffer S.
europepmc +1 more source
Cancer Science, EarlyView.tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley +1 more source
An RNAi screen of RNA helicases identifies eIF4A3 as a regulator of embryonic stem cell identity. [PDF]
Nucleic Acids Res, 2022 Li D +6 more
europepmc +1 more source
The DNA/RNA Helicase SETX Maintains R‐Loop Homeostasis to Promote Chemoresistance in Ovarian Cancer
Cancer Science, EarlyView.SETX maintains R‐loop homeostasis by resolving excessive R‐loops, thereby promoting tumor initiation and chemoresistance. Deficiency of SETX leads to accumulation of unsolved pathological R‐loops, resulting in irreparable DNA damage and ultimately leading to tumor suppression and chemosensitivity.
Zi‐Wei Hu +13 more
wiley +1 more source
DEAD-Box RNA Helicases DDX3X and DDX5 as Oncogenes or Oncosuppressors: A Network Perspective. [PDF]
Cancers (Basel), 2022 Secchi M +4 more
europepmc +1 more source
PABPC1 in Cancer: From a Translational Housekeeper to a Stress‐Responsive Regulatory Hub
Cancer Science, EarlyView.PABPC1 shifts from a translational housekeeper to a stress‐responsive oncogenic hub via phase separation, PTMs, and non‐coding RNA crosstalk, selectively driving oncogene translation and therapy resistance in cancer. ABSTRACT PABPC1, long recognized as a constitutive translational housekeeper, has emerged as a stress‐responsive translational ...
Cuiwei Zhang, Ye Zhu, Wenbo Long
wiley +1 more source
Host Cellular RNA Helicases Regulate SARS-CoV-2 Infection. [PDF]
J Virol, 2022 Ariumi Y.
europepmc +1 more source
Cell Proliferation, EarlyView.The lichen‐derived metabolite methyl 4‐O‐demethylbarbatate (Me‐4‐O‐DBA) suppresses glioma stemness, motility, and metabolic plasticity through inhibition of HIF‐1α signaling and synergistically enhances temozolomide activity, highlighting a potential strategy to target stemness‐driven therapeutic resistance in glioma.
Rui Zhou +8 more
wiley +1 more source