Results 111 to 120 of about 1,593,705 (264)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

RNA interference-based nanosystems for inflammatory bowel disease therapy

, 2016
Jian Guo,1 Xiaojing Jiang,1 Shuangying Gui1,2 1Department of Pharmaceutics, College of Pharmacy, Anhui University of Chinese Medicine, 2Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, Anhui, People’s Republic of China ...
Gui SY, Guo J, Jiang XJ
core  

Cosmic silence and viral noise: transcriptomic crosstalk in Caenorhabditis elegans under simulated space conditions

Frontiers in Microbiology
BackgroundSpaceflight environments pose unique physiological challenges due to al-tered gravity and radiation exposure.MethodsTo investigate how these abiotic stressors interact with viral infections, we ana-lyzed the transcriptomic response of ...
Ana Villena-Giménez, Esmeralda G. Legarda, Rubén González, Victoria G. Castiglioni, Victoria G. Castiglioni, Santiago F. Elena, Santiago F. Elena   +6 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Data analysis of the RNA interference assays.

, 2013
Data analysis of the RNA interference assays.
Cheng-Yuan Kao (228467), Raffi V. Aroian (103098), Ya-Luen Yang (366658), Audrey Bellier (228478), Chang-Shi Chen (256170), Ferdinand C. O. Los (103091), Huan-Da Chen (366659)   +6 more
core   +1 more source

MDM2 inhibitor induces apoptosis in colon cancer cells through activation of the CHOP-DR5 pathway, independent of p53 phenotype

Frontiers in Pharmacology
IntroductionMurine double minute 2 (MDM2), a key negative regulator of p53, forms a feedback loop with p53 to drive tumor progression, including colorectal cancer.
Manman Lu, Manman Lu, Yingli Ren, Sijia Feng, Shenggen Wang, Weiyue Xia, Baoru Gu, Yuhou Shen, Yuhou Shen, Aimin Yue, Aimin Yue, Na Li, Yongxi Zhang, Yongxi Zhang, Jiateng Zhong, Jiateng Zhong, Jiateng Zhong   +16 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Functions of RNAi Pathways in Ribosomal RNA Regulation

Argonaute proteins, guided by small RNAs, play crucial roles in gene regulation and genome protection through RNA interference (RNAi)-related mechanisms.
Shatskikh, Aleksei S, Klenov, Mikhail S, Fefelova, Elena A   +2 more
core   +1 more source

Impact of the Transboundary Interference Inhibitor on RNAi and the Baculovirus Expression System in Insect Cells

Insects
RNA interference inhibitors were initially discovered in plant viruses, representing a unique mechanism employed by these viruses to counteract host RNA interference.
Hao Zheng, Hengfeng Zhao, Haifan Xiong, Mian Muhammad Awais, Songrong Zeng, Jingchen Sun   +5 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source