Results 121 to 130 of about 1,593,705 (264)
HIF-2α-dependent induction of miR-29a restrains TH1 activity during T cell dependent colitis
Nature CommunicationsMetabolic imbalance leading to inflammatory hypoxia and stabilization of hypoxia-inducible transcription factors (HIFs) is a hallmark of inflammatory bowel diseases.
Agnieszka K. Czopik +21 more
doaj +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Getting the host antiviral machinery back on track: Targeting viral suppressors of RNA interference
Despite the successful efforts at curtailing the recent COVID-19 pandemic, the persistent threat of long-term SARS-CoV-2 infections, co-infections, and other pandemic potential viruses remains an ongoing and pressing issue.
Idris, A +4 more
core +1 more source
Conditional RNA interference in mammalian cells via RNA transactivation
Nature CommunicationsRNA interference (RNAi) is a powerful tool for sequence-specific gene knockdown in therapeutic and research applications. However, spatiotemporal control of RNAi is required to decrease nonspecific targeting, potential toxicity, and allow targeting of ...
Yu Zhou +5 more
doaj +1 more source
Microbiology SpectrumEnvironmental conditions fundamentally shape host-pathogen interactions; however, how multiple extreme abiotic stressors combine to influence infection outcomes remains poorly understood.
Ana Villena-Giménez +5 more
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Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Transfer RNA and Origins of RNA Interference
Frontiers in Molecular Biosciences, 2021 Andrey Grigoriev
doaj +1 more source