Results 131 to 140 of about 288,613 (251)

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

Phytophthora capsici carries and differentially expresses genes for the RNA interference pathway. [PDF]

PLoS One
Sevillano-Serrano J, Rojas-Rojas FU, Méndez-Bravo A, Calderón-Cortés N, Shimada-Beltrán H, Vega-Arreguín J.   +5 more
europepmc   +1 more source

Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?

Arthritis Care &Research, Accepted Article.
Objective The objective is to describe and compare demographic, clinical and serological characteristics of systemic sclerosis (SSc) patients according to ethnic background. Methods Participants enrolled in the Canadian Scleroderma Research Group cohort who self‐identified to a single ethnicity group were included.
Danick Goulet, Camille Guertin, Maggie Larché, Isabelle Ferdinand, Marie Hudson, May Y. Choi, Mohammed Osman, Janet Pope, Carter Thorne, Murray Baron, Canadian Scleroderma Research Group, M. Baron, M.Y. Choi, P. Docherty, P.R. Fortin, M. Fritzler, G. Gyger, S. Hoa, M. Hudson, A. Ikic, N. Jones, H. Kim, N. Khalidi, M. Larché, S. LeClercq, N. Maltez, A. Man, A. Masetto, J. Pope, D. Robinson, E. Sutton, C. Thorne, Sasha Bernatsky, Sabrina Hoa   +33 more
wiley   +1 more source

Induction of antiviral RNA interference by avian coronavirus IBV in PBMCs-Mφ. [PDF]

Cell Commun Signal
Wu Y, Zuo J, Jiang H, Ji W, Xiong N, Wang Z, Lin J, Yang Q.   +7 more
europepmc   +1 more source

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

Protocol for gene knockdown in Trichoplax adhaerens using a silica nanoparticle-mediated RNA interference technique. [PDF]

STAR Protoc
Guo Q, Li W, Zheng W, Qiu M, Zhao C.
europepmc   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Pull‐and‐Push Nanotherapeutic Hydrogels: Scavenging Inflammatory Triggers While Driving Tissue Regeneration in Burn Wounds

Advanced Functional Materials, EarlyView.
A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim, Seong‐Jin Shin, Sak Lee, Nandin Mandakhbayar, Ji‐Hye Kang, Da‐Young Kong, Seong‐Doo Hong, Ueon Sang Shin, Hae‐Won Kim, Jung‐Hwan Lee   +9 more
wiley   +1 more source

RNA interference therapy targeting coagulation factor XI: a first-in-human trial of RBD4059 (vortosiran). [PDF]

Blood Adv
Gabrielsen A, Ueckert S, Nilsson C, Egnell AC, Fu J, Wikström J, Svedlund S, Friend R, Zhang H, Liang Z, Gao S, Gan LM.   +11 more
europepmc   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source