Results 161 to 170 of about 508,217 (335)

Small nucleolar RNA interference induced by antisense or double-stranded RNA in trypanosomatids

, 2003
Xue‐hai Liang, Qing Liu, Shulamit Michaeli   +2 more
openalex   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The Aedes aegypti RNA interference response against Zika virus in the context of co-infection with dengue and chikungunya viruses

, 2023
Mayke Leggewie, Esther Schnettler
openalex   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Raw data for ‘Validation of a commercially available anti-REDD1 antibody using RNA interference and REDD1-/- mouse embryonic fibroblasts’

, 2016
Deborah Grainger, Lydia Kutzler, Sharon L. Rannels, Scot R. Kimball   +3 more
openalex   +1 more source

Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria [PDF]

, 2019
Eliane Sardh, Pauline Harper, Manisha Balwani, Penelope E. Stein, David C. Rees, D. Montgomery Bissell, Robert J. Desnick, Charles Parker, John D. Phillips, Herbert L. Bonkovsky, Daphne Vassiliou, Craig Penz, Amy Chan-Daniels, Qiuling He, William Querbes, Kevin Fitzgerald, Jae Bum Kim, Pushkal Garg, Akshay Vaishnaw, Amy Simon, Karl E. Anderson   +20 more
openalex   +1 more source

Supplementary table 1 from Pharmaceutical Interference of the EWS-FLI1–driven Transcriptome By Cotargeting H3K27ac and RNA Polymerase Activity in Ewing Sarcoma

, 2023
Daniel A.R. Heisey, Sheeba Jacob, Timothy L. Lochmann, Richard Kurupi, Maninderjit S. Ghotra, Marissa L. Calbert, Mayuri Shende, Yuki Kato Maves, Jennifer E. Koblinski, Mikhail G. Dozmorov, Sosipatros A. Boikos, Cyril H. Benes, Anthony C. Faber   +12 more
openalex   +2 more sources

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Ethical Perspectives on RNA Interference Therapeutics

International Journal of Medical Sciences, 2008
RNA interference is a mechanism for controlling normal gene expression which has recently begun to be employed as a potential therapeutic agent for a wide range of disorders, including cancer, infectious diseases and metabolic disorders.
Mette Ebbesen, Thomas G. Jensen, Svend Andersen, Finn Skou Pedersen
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