Results 181 to 190 of about 508,217 (335)

Depletion of procathepsin D gene expression by RNA interference – A potential therapeutic target for breast cancer [PDF]

, 2007
Sujata Saraswat Ohri, Aruna Vashishta, Mary Proctor, Martin Fusek, Václav Větvička   +4 more
openalex   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Editorial: Non-coding genome and endocrinology: from bench to bedside

Frontiers in Endocrinology, 2023
Radu Pirlog, Kinga Nemeth, George Adrian Calin, George Adrian Calin   +3 more
doaj   +1 more source

Transcription-replication conflict resolution by nuclear RNA interference. [PDF]

Mol Cell
Cheng T, Roche B, Abderahmane F, Touat-Todeschini L, Fréon K, Lakhani AA, Bhattacharjee S, Spielmann LG, Jenen E, Choi C, Ren J, Verdel A, Lambert SAE, Martienssen RA.   +13 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

[Expression of Concern] RUNX2 RNA interference inhibits the invasion of osteosarcoma. [PDF]

Oncol Lett
Zeng H, Xu X.
europepmc   +1 more source

Association of Patisiran, an RNA Interference Therapeutic, With Regional Left Ventricular Myocardial Strain in Hereditary Transthyretin Amyloidosis [PDF]

, 2019
Masatoshi Minamisawa, Brian Claggett, David Adams, Arnt V. Kristen, Giampaolo Merlini, Michel Slama, Angela Dispenzieri, Amil M. Shah, Rodney H. Falk, Verena Karsten, Marianne T. Sweetser, Jihong Chen, Richard J. Riese, Joshua R. Vest, Scott D. Solomon   +14 more
openalex   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Targeting HBV with RNA interference: Paths to cure. [PDF]

Sci Transl Med
Iannacone M, Beccaria CG, Allweiss L, Lucifora J, Tavis JE, Gehring AJ, Dandri M.   +6 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source