Results 181 to 190 of about 389,403 (285)

Autopolyploidization‐Induced Chromatin Remodeling Regulates Leaf Size Variation in Brassica rapa

Advanced Science, EarlyView.
This study demonstrates that monoploid, diploid, and autotetraploid Brassica rapa lines derived from the same genome exhibit distinct leaf morphology. Ploidy changes remodel chromatin accessibility and histone modifications to regulate gene expression, while key transcription factors BrGRF13 and BrARF11 control leaf size and polarity, driving ...
Haoyuan Dong, Yanhong Liu, Yuanming Liu, Shuxin Xuan, Huanhuan Chen, Lai Wei, Guibao Zhang, Hongcui Pei, Zilong Dai, Yanhua Wang, Jinzhu Qiao, Shuangxia Luo, Xueping Chen, Yiguo Hong, Jianjun Zhao, Shuxing Shen, Zefu Lu, Aixia Gu   +17 more
wiley   +1 more source

Nanopore based RNA methylation profiling of a circulating lung cancer biomarker. [PDF]

Commun Med (Lond)
Sanchez-Delgado M, Frank M, Šišmiš T, Kahraman M, Daniel-Moreno A, Mummery E, Ceiler J, Skottke J, Bieg-Salazar C, Hinkfoth F, Rudolf C, Weiblen R, Tikk K, Sikosek T, Steinkraus BR, Horos R, Urda M, Rajakumar T.   +17 more
europepmc   +1 more source

P154: The second known case of CNP-related hypomyelinating leukodystrophy is diagnosed by RNA-seq and demonstrates an abnormal blood methylation profile* [PDF]

Joseph Farris, Jia Tan, Emily Blake, N William, Ralitza Gavrilova, Eric W. Klee   +5 more
openalex   +1 more source

Long noncoding RNA-HOTAIR affects chemoresistance by regulating HOXA1 methylation in small cell lung cancer cells [PDF]

, 2015
Shun Fang, Hong-Yi Gao, Yue Tong, Jie Yang, Ruixiang Tang, Yuchun Niu, Man Li, Linlang Guo   +7 more
openalex   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source

m7G RNA methylation in cancer: Effect, mechanism and clinical application. [PDF]

Clin Transl Med
Dang P, Li K, Sun Z.
europepmc   +1 more source

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, EarlyView.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

Research progress on m6A RNA methylation modification in human reproduction related diseases. [PDF]

Eur J Med Res
Sui X, Liu Y, Wang Z, Sui Y, Gao L.
europepmc   +1 more source

METTL3-dependent m6A RNA methylation regulates transposable elements and represses human naïve pluripotency through transposable element-derived enhancers [PDF]

Weiyu Zhang, Haifeng Fu, Yunying Huang, Ming Zeng, Xiangyu Ouyang, Xiao Wang, Degong Ruan, Lingzhi Ma, Xinning Hu, Jilong Guo, Justin W. Galardi, Gordon Dougan, William S.B. Yeung, Lei Li, Jianqiao Liu, Cedric Feschotte, Pentao Liu   +16 more
openalex   +1 more source

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, EarlyView.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source