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RNA Modifications in Hematologic Malignancies
2023Chemical modifications on macromolecules such as DNA, RNA and proteins play important roles in almost all biological processes. The revival of RNA modification research began with the discovery of RNA modification machineries, and with the development of better techniques for characterizing and profiling these modifications at the transcriptome-wide ...
Yashu, Li, Wen, Tian, Haojian, Zhang
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Dynamic RNA modifications in disease
Current Opinion in Genetics & Development, 2014While the presence of 6-methyladenosine (m6A) modifications in mRNA was noted several decades ago, the first enzyme reversing this modification was identified very recently. Today we know of two methyltransferases introducing m6A in mRNA--METTL3 and METTL14--and two demethylases that remove it have been identified-FTO (ALKBH9) and ALKBH5. The conserved
Arne, Klungland, John Arne, Dahl
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Modifications of aminoglycoside antibiotics targeting RNA
Medicinal Research Reviews, 2006AbstractThe increased awareness of the central role of RNA has led to realization that RNA, as structural and functional information accumulation, is also drug target to small molecular therapy. Aminoglycosides are a group of well‐known antibiotics, which function through binding to specific sites in prokaryotic ribosomal RNA (rRNA) and affecting the ...
Jian, Zhou +3 more
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Chemical Modification of Small Interfering RNA
2011Chemically synthesized siRNAs are widely used for gene silencing. For in vitro applications, stability, delivery, and immunological issues are rarely problematic, but for in vivo applications the situation is different. Limited stability, undesirable pharmacokinetic behaviour, and unanticipated side effects from the immune system call for more careful ...
Bramsen, Jesper Bertram, Kjems, Jørgen
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