Results 221 to 230 of about 835,495 (286)

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Huashi Runzao decoction for primary Sjögren disease: a double-blind, randomized controlled trial combined with m6A and m5C RNA modification analysis. [PDF]

Front Pharmacol
Huang Z, Deng T, Zhang X, Lei C, Zhang Y, Yang J, He Q, Liao J, Chen J, Yang L, Gu X, Luo J, Xiao C, Tao Q.   +13 more
europepmc   +1 more source

A genomic analysis of RNA polymerase II modification and chromatin architecture related to 3′ end RNA polyadenylation [PDF]

, 2008
Zheng Lian, Alexander Karpikov, Lian Jin, Milind Mahajan, Stephen E. Hartman, Mark Gerstein, M Snyder, Sherman M. Weissman   +7 more
openalex   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Regulation of Skeletogenic Pathways by m6A RNA Modification: A Comprehensive Review. [PDF]

Calcif Tissue Int
Ahi EP.
europepmc   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Biological interpretation of DNA/RNA modification by ALKBH proteins and their role in human cancer. [PDF]

Eur J Med Res
Yang S, Xing J, Song Y, Cui J, Bao L, Xi Q, Zuo Y.   +6 more
europepmc   +1 more source

Transdermal Trafficking of Notoginsenoside R1 (NGR1) Via BCRP: Unveiling a Novel Mechanism and Therapeutic Strategy for RNA m6A Modification Involved and UVB-Induced Skin Sunburn Injury

Xiaokang Liu, Shuyun Liang, Xiaobo Sun, Tong Zhang, De-an Guo, Jiyu Gong, Zizhao Yang   +6 more
openalex   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Targeting m⁶A RNA Modification in Tumor Therapeutics. [PDF]

Curr Oncol
Mao Z, Li M, Wang S.
europepmc   +1 more source