Results 101 to 110 of about 708,746 (292)

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Electrically Guided DNA Immobilization and Multiplexed DNA Detection with Nanoporous Gold Electrodes

Nanomaterials, 2018
Molecular diagnostics have significantly advanced the early detection of diseases, where the electrochemical sensing of biomarkers (e.g., DNA, RNA, proteins) using multiple electrode arrays (MEAs) has shown considerable promise.
Jovana Veselinovic, Zidong Li, Pallavi Daggumati, Erkin Seker   +3 more
doaj   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

Inducing macrophage M2-Type polarization via anodized anisotropic TiO2 nanoporous topography on titanium surfaces

BMC Oral Health
Background Dental implant success critically depends on soft tissue integration (STI) to prevent peri-implantitis. Macrophages, key immune regulators, exhibit distinct pro-inflammatory (M1) or anti-inflammatory/pro-healing (M2) phenotypes, significantly ...
Siyu Xie, Wei Wei, Bin Luo, Jiangqi Hu, Yunping Lu, Lin He, Xiaoyu Wang, Xu Sun, Qingsong Jiang, Tianxiao Han   +9 more
doaj   +1 more source

Development of a Dual Gene-Targeted Multi-Sirna with Branched Structure and Its Role in the Therapy of Liver Cancer

Pharmaceuticals
Background: Hepatocellular carcinoma (HCC) remains a major global health challenge with limited therapeutic options. Although RNA interference (RNAi) enables precise gene silencing, its clinical application is restricted by siRNA instability, inefficient
Mingdong Lu, Wenqin Jiang, Zhekai Liu, Yiqing Liu, Fangli Wu, Weibo Jin   +5 more
doaj   +1 more source

A twist in the tail : SHAPE mapping of long-range interactions and structural rearrangements of RNA elements involved in HCV replication [PDF]

, 2011
The RNA structure and long-range interactions of the SL9266 cis-acting replication element located within the NS5B coding region of hepatitis C virus (HCV) were determined using selective 2′-hydroxyl acylation analysed by primer extension.
Tuplin, Andrew, Struthers, Madeleine, Struthers, M., Andrew Tuplin, Tuplin, A., Struthers, M, Madeleine Struthers, Simmonds, Peter, David J. Evans, Tuplin, A, Evans, DJ, Peter Simmonds, Evans, David J., Simmonds, P., Evans, D. J., Simmonds, P   +15 more
core   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Mesoscopic Structure of Lipid Nanoparticles Studied by Small-Angle X-Ray Scattering: A Spherical Core-Triple Shell Model Analysis

Membranes
Lipid nanoparticles (LNPs) are widely recognized as effective drug delivery systems for RNA therapeutics because their efficacy is critically dependent on structural organization.
Hao Li, Panqi Song, Yiwen Li, Shuyang Tu, Mehwish Mehmood, Liang Chen, Na Li, Qiang Tian   +7 more
doaj   +1 more source

Repeat RNAs associate with replication forks and post-replicative DNA

, 2020
Non-coding RNA has a proven ability to direct and regulate chromatin modifications by acting as scaffolds between DNA and histone-modifying complexes. However, it is unknown if ncRNA plays any role in DNA replication and epigenome maintenance, including ...
Groth, Anja, Gylling, Helena, González Aguilera, Cristina, Smith, Martin A, Kaczorowski, Dominik C, Lund, Anders H., Gylling, Helene M., Gylling, Helene M, Gonzalez-Aguilera, Cristina, Smith, Martin A., Smith, Martina A., Kaczorowski, Dominik C., Lund, Anders H   +12 more
core   +1 more source

Light‐Activated Ruthenium Nanoclusters Reprogram the Metabolic‐Quorum Sensing Axis for Precision Periodontitis Therapy

Advanced Science, EarlyView.
Under 660 nm visible light, Ru NCs efficiently photocatalyze nitrate‐to‐ammonium conversion and modulate oral nitrogen metabolism. They precisely perturb Veillonella parvula, block its key support to Porphyromonas gingivalis, and exert an “inhibiting without killing” antivirulence effect.
Jing Zhou, Xiaolin Sun, Chengyu Liu, Yujia Shi, Meiqi Li, Meng Bo, Jingjie Zhai, Chunyan Li, Zhennan Wu, Xue Bai, Lin Wang   +10 more
wiley   +1 more source