Results 91 to 100 of about 883,773 (191)

Hybrid RNA/DNA origami nanostructures

Nucleic Acid Insights
Within the past 20 years, structural DNA nanotechnology has evolved from simple DNA tiles composed of a few strands to more advanced DNA origami nanostructures composed of dozens of unique strands. Meanwhile, the shape space of various RNA structures has also significantly expanded, and the tools for creating custom DNA and RNA nanostructures have been
Olavi Reinsalu, Pranya Nepoliyan, Sven Oras, Veikko Linko   +3 more
openaire   +1 more source

Programmable Tetrahedral DNA‐RNA Nanocages Woven with Stimuli‐Responsive siRNA for Enhancing Therapeutic Efficacy of Multidrug‐Resistant Tumors

Advanced Science
Multidrug resistance (MDR) is a major obstacle limiting the effectiveness of chemotherapy against cancer. The combination strategy of chemotherapeutic agents and siRNA targeting drug efflux has emerged as an effective cancer treatment to overcome MDR ...
Changmai Chen, Maocheng Yu, Qing Li, Ying Zhou, Mengting Zhang, Shanyu Cai, Jiaojiao Yu, Zhongnan Huang, Jiaan Liu, Ye Kuang, Xinjing Tang, Wei Chen   +11 more
doaj   +1 more source

Splenic dendritic cell-targeting mRNA transfection of H-type ionizable lipid-based LNPs for enhancing tumor immunotherapy

Bioactive Materials
Messenger RNA (mRNA) vaccine was emerging as a promising treatment for tumor immunotherapy. Highly efficient antigen-presenting ability in tumor immunotherapy through splenic dendritic cell (DC)-targeting mRNA delivery system was very important, but it ...
Xin Chen, Xiaoyu Li, Yi Yan, Zhenwen Li, Jinyue Li, Junjie Xue, Cuiting Bai, Jin Li, Di Wu, Xiaoyan Liu, Yuanjun Zhu, Jian-Cheng Wang   +11 more
doaj   +1 more source

Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing

, 2010
We report that combining a DNA analog (2?F-ANA) with rigid RNA analogs [2?F-RNA and/or locked nucleic acid (LNA)] in siRNA duplexes can produce gene silencing agents with enhanced potency. The favored conformations of these two analogs are different, and
Alain, Tommy, Robert, Francis, Aishwarya, Veenu, Pelletier, Jerry, Deleavey, Glen F., Gewirtz, Alan M., Sonenberg, Nahum, Damha, Masad J., Kalota, Anna, Watts, Jonathan K.   +9 more
core   +1 more source

Antiviral potential of sugarcane bagasse-derived carbon quantum dots against SARS-CoV-2, and herpes simplex virus-1

Discover Applied Sciences
Viral diseases pose a serious global threat due to their ability to spread quickly and mutate. The ongoing SARS-CoV-2 pandemic exemplifies this challenge, as effective treatments and vaccines are still under development.
Hebat-Allah S. Tohamy, Mohamed El-Sakhawy, Sahar Abd Al-Daim, Ahmed N. El Taweel   +3 more
doaj   +1 more source

DOTAP-functionalized DNA nanocages enable efficient miR168d trafficking to antagonize PVY infection by modulating HSP90-5 homeostasis

Chemical and Biological Technologies in Agriculture
Background Plant viruses cause severe agricultural losses. Conventional pesticides have issues such as residues and resistance, while the delivery efficiency of functional microRNAs in RNA interference strategies is low.
Yanwei Gong, Junying Zhang, Liu Yang, Xinyi Zhao, Lingdie Wang, Dong An, Lianqiang Jiang, Yubing Jiao, Lili Shen   +8 more
doaj   +1 more source

Quantitative Thermodynamic Characterization of Self-Assembling RNA Nanostructures

Abstract Recent developments in RNA nanotechnology have led to the rise in designing specific higher order RNA structures with functional goals in mind, such as drug delivery and immunomodulation. As researchers create RNA nanostructures with the goal of becoming common in the molecular biologists’ toolkit, more investigation is ...
Jordan Aposhian, Surya Pratap S. Deopa, Scott Horowitz, Joseph D. Yesselman   +3 more
openaire   +2 more sources

Quantification of disease-associated RNA tandem repeats by nanopore sensing. [PDF]

Nat Commun
Patiño-Guillén G, Pešović J, Panić M, Earle M, Ninković A, Petrușca S, Savić-Pavićević D, Keyser UF, Bošković F.   +8 more
europepmc   +2 more sources

Genome-wide kinetic profiling of pre-mRNA 3' end cleavage

Cleavage and polyadenylation is necessary for the formation of mature mRNA molecules. The rate at which this process occurs can determine the temporal availability of mRNA for subsequent function throughout the cell and is likely tightly regulated ...
Calvo-Roitberg, Ezequiel, Torres Ulloa, Leslie, Pai, Athma A   +2 more
core   +1 more source

Nanopore-Based Profiling of PEGylation in Nucleic Acid Therapeutics. [PDF]

J Am Chem Soc
Patiño Guillén G, Schmidt TT, Baumberg JJ, Szostak JW, Keyser UF, Bošković F.   +5 more
europepmc   +1 more source