Results 31 to 40 of about 966,777 (273)

Targeting Liver Cancer Stem Cells Using Engineered Biological Nanoparticles for the Treatment of Hepatocellular Cancer

Hepatology Communications, 2020
By exploiting their biological functions, the use of biological nanoparticles such as extracellular vesicles can provide an efficient and effective approach for hepatic delivery of RNA‐based therapeutics for the treatment of liver cancers such as ...
Kaori Ishiguro, Irene K. Yan, Laura Lewis‐Tuffin, Tushar Patel   +3 more
doaj   +1 more source

RNA-specific ribonucleotidyl transferases [PDF]

, 2007
RNA-specific nucleotidyl transferases (rNTrs) are a diverse family of template-independent polymerases that add ribonucleotides to the 3'-ends of RNA molecules.
Keller, W., Martin, G., W. Keller, G. Martin, Martin G, Keller W   +5 more
core   +1 more source

Nanotechnology-assisted RNA delivery. From nucleic acid therapeutics to COVIDvaccines [PDF]

, 2021
In recent years, the main quest of science has been the pioneering of the groundbreaking biomedical strategies needed for achieving a personalized medicine. Ribonucleic acids (RNAs) are outstanding bioactive macromolecules identified as pivotal actors in
De Sio L., Liguori A., Li X., Zargarian S. S., Pierini F., Gualandi C., Nakielski P., Petronella F., Costantini M., Presutti D., Rinoldi C., Wang Q., Ding B., Rinoldi C, Ding B, Pierini F, Wang Q, Gualandi C, Liguori A, Costantini M, De Sio L, Zargarian SS, Li X, Nakielski P, Petronella F, Presutti D   +25 more
core   +1 more source

mRNA vaccines: Past, present, future

Asian Journal of Pharmaceutical Sciences, 2022
mRNA vaccines have emerged as promising alternative platforms to conventional vaccines. Their ease of production, low cost, safety profile and high potency render them ideal candidates for prevention and treatment of infectious diseases, especially in ...
Mia Karam, Georges Daoud
doaj   +1 more source

Nucleic Acid Science – The Excitement of Discovery: Annual Symposium of the Chemical Society Zürich CGZ, Zürich, October 26, 2007

CHIMIA, 2007
The Chemical Society Zürich held its annual symposium on frontiers in nucleic acid science at the Eidgenössische Technische Hochschule Zürich.
Imre Berger, Christiane Schaffitzel, Christoph Bieniossek   +2 more
doaj   +1 more source

RNA Interference and Nanotechnology: A Promising Alliance for Next Generation Cancer Therapeutics

Frontiers in Nanotechnology, 2021
Cancer is a significant health hazard of the 21st century, and GLOBOCAN predicts increasing cancer incidence in the coming decades. Though several conventional treatment modalities exist, most of them end up causing off-target and debilitating effects ...
Guruprasadh Swaminathan, Aisha Shigna, Aviral Kumar, Vishnu Vardhan Byroju, Varsha Reddy Durgempudi, Lekha Dinesh Kumar   +5 more
doaj   +1 more source

Myostatin/Smad3 in Spinal Muscular Atrophy: Biomarkers of Disease Severity and Treatment Response

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Given the role of Myostatin (MSTN) in muscle homeostasis and its modulation by current spinal muscular atrophy (SMA) therapies, we investigated serum MSTN and, for the first time, its downstream effector Smad3 as candidate non‐invasive biomarkers in SMA patients undergoing disease‐modifying therapies (DMTs).
Giorgia Riolo, Claudia Dosi, Stefano Parravicini, Riccardo Zanin, Marta Cheli, Eleonora Giacopuzzi Grigoli, Amalia Canciello, Francesca Andreetta, Riccardo Masson, Silvia Bonanno, Stefania Marcuzzo, Lorenzo Maggi   +11 more
wiley   +1 more source

Protein-driven RNA nanostructured devices that function in vitro and control mammalian cell fate

Nature Communications, 2017
Nucleic acid nanotechnology has great potential for future therapeutic applications. Here the authors build protein-driven RNA nanostructures that can function within mammalian cells and regulate the cell fate.
Tomonori Shibata, Yoshihiko Fujita, Hirohisa Ohno, Yuki Suzuki, Karin Hayashi, Kaoru R. Komatsu, Shunsuke Kawasaki, Kumi Hidaka, Shin Yonehara, Hiroshi Sugiyama, Masayuki Endo, Hirohide Saito   +11 more
doaj   +1 more source

Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway [PDF]

, 2012
tRNA precursors, which are transcribed by RNA polymerase III, undergo end-maturation, splicing and base modifications. Hypomodified tRNAs, such as tRNAVal(AAC), lacking 7-methylguanosine and 5-methylcytidine modifications, are subject to degradation by a
Boguta, Magdalena, Turowski, Tomasz W., Karkusiewicz, Iwona, Kowal, J   +3 more
core   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source