Results 41 to 50 of about 2,070,961 (352)
Reverse Transcriptase- and RNA Packaging Signal-Dependent Incorporation of APOBEC3G into Hepatitis B Virus Nucleocapsids [PDF]
Journal of Virology, 2008 David H. H. Nguyen, Jianming Hu
semanticscholar +2 more sources
Packaging signals in single-stranded RNA viruses: nature’s alternative to a purely electrostatic assembly mechanism [PDF]
, 2013 The formation of a protective protein container is an essential step in the life-cycle of most viruses. In the case of single-stranded (ss)RNA viruses, this step occurs in parallel with genome packaging in a co-assembly process.
Bakker, S.E. +10 more
core +2 more sources
Development of a Novel Competitive qRT-PCR Assay to Measure Relative Lentiviral Packaging Efficiency
Molecular Therapy: Methods & Clinical Development, 2020 Third-generation HIV-1-derived lentiviral vectors are successfully used as therapeutic agents in various clinical applications. To further promote their use, we attempted to enhance vector infectivity by targeting the dimerization and packaging ...
Eirini Vamva +3 more
doaj +1 more source
Microbiology Spectrum, 2022 HIV-1 must package its RNA genome to generate infectious viruses. Recent studies have revealed that during genome packaging, HIV-1 not only excludes cellular mRNAs, but also distinguishes among full-length viral RNAs. Using NL4-3 and MAL molecular clones,
Jonathan M. O. Rawson +5 more
doaj +1 more source
Is HIV-1 RNA dimerization a prerequisite for packaging? Yes, no, probably? [PDF]
, 2004 During virus assembly, all retroviruses specifically encapsidate two copies of full-length viral genomic RNA in the form of a non-covalently linked RNA dimer.
Liang, Chen +2 more
core +3 more sources
Cooperative Mechanism of RNA Packaging Motor [PDF]
Journal of Biological Chemistry, 2005 P4 is a hexameric ATPase that serves as the RNA packaging motor in double-stranded RNA bacteriophages from the Cystoviridae family. P4 shares sequence and structural similarities with hexameric helicases. A structure-based mechanism for mechano-chemical coupling has recently been proposed for P4 from bacteriophage phi12.
Jiří Lísal, Roman Tuma
openaire +2 more sources
Mud2 functions in transcription by recruiting the Prp19 and TREX complexes to transcribed genes [PDF]
, 2007 The different steps of gene expression are intimately linked to coordinate and regulate this complex process. During transcription, numerous RNA-binding proteins are already loaded onto the nascent mRNA and package the mRNA into a messenger ...
Andersen, Ulrik L. +8 more
core +1 more source
How to package the RNA of HIV-1
eLife, 2020 Interactions between viral RNA and the integrase enzyme are required for HIV-1 particles to become infectious, a process that can be disrupted through multiple mechanisms.
Alex Kleinpeter, Eric O Freed
openaire +4 more sources
Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses
mBio, 2018 Selective packaging is a mechanism used by multiple virus families to specifically incorporate genomic RNA (gRNA) into virions and exclude other types of RNA. Lineage A betacoronaviruses incorporate a 95-bp stem-loop structure, the packaging signal (PS),
Jeremiah Athmer +11 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance HIV-1 must select and package its RNA genome from an abundant pool of cellular RNAs. To understand this essential replication step, we studied two nearly identical HIV-1 RNAs that are differentially encapsidated.
Olga A. Nikolaitchik +9 more
semanticscholar +1 more source