Investigation of HIV-1 Gag binding with RNAs and Lipids using Atomic Force Microscopy [PDF]
, 2019 Atomic Force Microscopy was utilized to study the morphology of Gag, {\Psi}RNA, and their binding complexes with lipids in a solution environment with 0.1{\AA} vertical and 1nm lateral resolution. TARpolyA RNA was used as a RNA control.
Chen, Shaolong +6 more
core +3 more sources
Physicochemical analysis of rotavirus segment 11 supports a 'modified panhandle' structure and not the predicted alternative tRNA-like structure (TRLS) [PDF]
, 2013 .Rotaviruses are a major cause of acute gastroenteritis, which is often fatal in infants. The viral genome consists of 11 double-stranded RNA segments, but little is known about their cis-acting sequences and structural elements.
A Heerschap +47 more
core +1 more source
RNAglib: a python package for RNA 2.5 D graphs [PDF]
Bioinformatics, 2021 AbstractSummaryRNA 3D architectures are stabilized by sophisticated networks of (non-canonical) base pair interactions, which can be conveniently encoded as multi-relational graphs and efficiently exploited by graph theoretical approaches and recent progresses in machine learning techniques.
Vincent Mallet +4 more
openaire +3 more sources
BMC Genomics, 2015 BackgroundLeishmania use exosomes to communicate with their mammalian hosts and these secreted vesicles appear to contribute to pathogenesis by delivering protein virulence factors to macrophages.
U. Lambertz +5 more
semanticscholar +1 more source
Rescue of splicing-mediated intron loss maximizes expression in lentiviral vectors containing the human ubiquitin C promoter. [PDF]
, 2014 Lentiviral vectors almost universally use heterologous internal promoters to express transgenes. One of the most commonly used promoter fragments is a 1.2-kb sequence from the human ubiquitin C (UBC) gene, encompassing the promoter, some enhancers, first
Cooper, Aaron R +3 more
core +1 more source
Cross- and Co-Packaging of Retroviral RNAs and Their Consequences [PDF]
Viruses, 2016 Retroviruses belong to the family Retroviridae and are ribonucleoprotein (RNP) particles that contain a dimeric RNA genome. Retroviral particle assembly is a complex process, and how the virus is able to recognize and specifically capture the genomic RNA (gRNA) among millions of other cellular and spliced retroviral RNAs has been the subject of ...
Lizna Ali, Tahir Rizvi, Farah Mustafa
openaire +4 more sources
Viral Genome Segmentation Can Result from a Trade-Off between Genetic Content and Particle Stability [PDF]
, 2011 The evolutionary benefit of viral genome segmentation is a classical, yet unsolved question in evolutionary biology and RNA genetics. Theoretical studies anticipated that replication of shorter RNA segments could provide a replicative advantage over ...
Arias, Armando +7 more
core +3 more sources
On the Selective Packaging of Genomic RNA by HIV-1 [PDF]
Viruses, 2016 Like other retroviruses, human immunodeficiency virus type 1 (HIV-1) selectively packages genomic RNA (gRNA) during virus assembly. However, in the absence of the gRNA, cellular messenger RNAs (mRNAs) are packaged. While the gRNA is selected because of its cis-acting packaging signal, the mechanism of this selection is not understood.
Mauricio Comas-Garcia +2 more
openaire +4 more sources
Packaging of Non-Coding RNAs into Herpesvirus Virions: Comparisons to Coding RNAs [PDF]
Frontiers in Genetics, 2011 The herpesviruses are a family of large DNA viruses capable of establishing lifelong infections. Recent reports have shown that herpesviruses package non-coding RNA into virions; this follows earlier observations showing that coding RNAs are detected in virions.
Melanie Ann Amen +4 more
openaire +4 more sources