Results 71 to 80 of about 107,453 (245)
Cross- and Co-Packaging of Retroviral RNAs and Their Consequences [PDF]
Viruses, 2016 Retroviruses belong to the family Retroviridae and are ribonucleoprotein (RNP) particles that contain a dimeric RNA genome. Retroviral particle assembly is a complex process, and how the virus is able to recognize and specifically capture the genomic RNA (gRNA) among millions of other cellular and spliced retroviral RNAs has been the subject of ...
Lizna Ali, Tahir Rizvi, Farah Mustafa
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Mechanisms of Messenger RNA Packaging and Export
Annual Review of Cell and Developmental BiologyThe packaging and export of messenger RNA (mRNA) are essential cellular pathways that bridge the nuclear and cytoplasmic phases of eukaryotic gene expression. During their nuclear maturation, mRNAs are packaged by proteins into mRNA ribonucleoproteins (mRNPs).
Faraway, Rupert +2 more
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Packaging in a yeast double-stranded RNA virus [PDF]
Journal of Virology, 1995 The yeast virus ScV-L1 has only two genes, cap and pol, which encode the capsid polypeptide and the viral polymerase, respectively. The second gene is translated only as a cap-pol fusion protein. This fusion protein is responsible for recognition of a specific small stem and loop region of the viral plus strands, of 19 to 31 bases in length, ensuring ...
W, Yao, K, Muqtadir, J A, Bruenn
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RNA-RNA interactions in viral genome packaging
, 2023 RNA ist eines der am häufigsten vorkommenden Makromoleküle und spielt bei allen biologischen Prozessen eine wesentliche Rolle. Diese Doktorarbeit besteht aus zwei Projekten, die sich auf die RNA-Struktur und RNA-RNA-Interaktionen bei der viralen Genomverpackung konzentrieren.
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Packaging host RNAs in small RNA viruses [PDF]
Cell Cycle, 2012 Viruses from all walks of life employ diverse strategies to ensure the specific encapsidation of their own viral genomes and to avoid the packaging of host nucleic acids. While the packaging of host nucleic acid may attenuate viral infectivity, this may also have extended biological implications.
Routh, Andrew +2 more
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Nature Communications, 2018 Influenza A virus packaging depends on interactions between nucleoprotein (NP) and viral RNA (vRNA), but the pattern of NP binding is unclear. Using PAR-CLIP, Williams et al.
Graham D. Williams +6 more
doaj +1 more source