Results 181 to 190 of about 2,226,379 (341)

Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II

Nature, 2018
Huasong Lu, Dan Yu, A. Hansen, S. Ganguly, Rongdiao Liu, A. Heckert, X. Darzacq, Qiang Zhou   +7 more
semanticscholar   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Applying the brakes to transcription: regulation of gene expression by RNA polymerase pausing. [PDF]

J Bacteriol
Jayasinghe OT, Babitzke P.
europepmc   +1 more source

RNA polymerase activity in purified reoviruses.

, 1968
Aaron J. Shatkin, Jean D. Sipe
openalex   +1 more source

The nature of the interaction of nucleosomes with a eukaryotic RNA polymerase II [PDF]

, 1979
David M.J. Lilley, Melanie Jacobs, Michael Houghton   +2 more
openalex   +1 more source

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Targeting RNA Polymerase I in Ewing Sarcoma Treatment. [PDF]

Cancer Sci
Bruce A, Anchondo G, Carter R, Guerrero Pacheco S, Kambala HS, Cortez E, Parker K, Su L.   +7 more
europepmc   +1 more source

Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells

Advanced Healthcare Materials, EarlyView.
Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex, Ursula Menzel, Yann Ladner, Angela R. Armiento, Martin J. Stoddart   +4 more
wiley   +1 more source

RNA Polymerase III-Transcribed RNAs in Health and Disease: Mechanisms, Dysfunction, and Future Directions. [PDF]

Int J Mol Sci
Sun L, Chen M, Wang X.
europepmc   +1 more source

Poliovirus-specific primer-dependent RNA polymerase able to copy poly(A). [PDF]

, 1977
James B. Flanegan, David Baltimore
openalex   +1 more source