Results 11 to 20 of about 2,760,256 (386)
BioTechnologia, 2022 Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected 235.6 million people worldwide. In the present study, RNA-dependent RNA polymerase (RdRp) (PDB Id: 6M71) of SARS-CoV-2, an essential enzyme ...
Nahid Akhtar +5 more
doaj +1 more source
Structure of the RNA-dependent RNA polymerase from COVID-19 virus
Science, 2020 The COVID-19 RNA-synthesizing machine Many in the scientific community have mobilized to understand the virus that is causing the global coronavirus disease 2019 (COVID-19) pandemic. Gao et al.
Yan Gao +27 more
semanticscholar +1 more source
St. Petersburg Polytechnical University Journal: Physics and Mathematics, 2022 This work presents the results of single-molecular studies of the effect of magnesium ions on the dynamic characteristics of transcription elongation of bacterial RNA polymerase.
Arseniev Anatolii +6 more
doaj +1 more source
Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance While the current COVID-19 pandemic continues, the US Food and Drug Administration (FDA) has approved only one drug against the virus—remdesivir.
K. Naydenova +14 more
semanticscholar +1 more source
Cell, 1999 The appearance of these structures represents a historic advance in our understanding of one of molecular biology's most remarkable enzymes. Here we have suggested several possible structural bases for key steps in its function. Although speculative, they should serve as stimuli for future work.
Mooney, Rachel Anne, Landick, Robert
openaire +2 more sources
bioRxiv, 2020 The pandemic of Corona Virus Disease 2019 (COVID-19) caused by SARS-CoV-2 has become a global crisis. The replication of SARS-CoV-2 requires the viral RNA-dependent RNA polymerase (RdRp), a direct target of the antiviral drug, Remdesivir.
W. Yin +21 more
semanticscholar +1 more source
Gene Transcription as a Limiting Factor in Protein Production and Cell Growth
G3: Genes, Genomes, Genetics, 2020 Cell growth is driven by the synthesis of proteins, genes, and other cellular components. Defining processes that limit biosynthesis rates is fundamental for understanding the determinants of cell physiology.
Eyal Metzl-Raz +3 more
doaj +1 more source
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant
Journal of Translational Medicine, 2020 Background SARS-CoV-2 is a RNA coronavirus responsible for the pandemic of the Severe Acute Respiratory Syndrome (COVID-19). RNA viruses are characterized by a high mutation rate, up to a million times higher than that of their hosts.
M. Pachetti +11 more
semanticscholar +1 more source
Current Opinion in Structural Biology, 2009 The recently solved X-ray crystal structures of archaeal RNA polymerase (RNAP) allow a structural comparison of the transcription machinery among all three domains of life. Archaeal transcription is very simple and all components, including the structures of general transcription factors and RNAP, are highly conserved in eukaryotes. Therefore, it could
Akira, Hirata, Katsuhiko S, Murakami
openaire +2 more sources
Contractions of the C-Terminal Domain of Saccharomyces cerevisiae Rpb1p Are Mediated by Rad5p
G3: Genes, Genomes, Genetics, 2020 The C-terminal domain (CTD) is an essential domain of the largest subunit of RNA polymerase II, Rpb1p, and is composed of 26 tandem repeats of a seven-amino acid sequence, YSPTSPS.
Taylor Stewart +3 more
doaj +1 more source