Single-peptide DNA-dependent RNA polymerase homologous to multi-subunit RNA polymerase [PDF]
Nature Communications, 2017 Although all known RNA polymerases have multiple subunits, unrelated single-subunit polymerases have also been described. Here, the authors describe a single-subunit RNA polymerase from the SPβ prophage ofBacillus subtilis, which shares homology to multi-
David Forrest +3 more
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Poliovirus-specific primer-dependent RNA polymerase able to copy poly(A) [PDF]
, 1977 A template-dependent RNA polymerase has been isolated from poliovirus-infected cells by assaying for the ability of the enzyme to copy poly(A) complexed to an oligo(U) primer.
Baltimore, David, Flanegan, James B.
core +3 more sources
Amplification of RNA by an RNA polymerase ribozyme [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance Darwinian life requires the ability to replicate genotypes and express phenotypes. Although all extant life relies on protein enzymes to accomplish these tasks, life in the ancestral RNA world would have used only RNA enzymes. Here, we report the in vitro evolution of an improved RNA polymerase ribozyme that is able to synthesize
David P Horning, G. F. Joyce
semanticscholar +3 more sources
Architecture of the spinach plastid-encoded RNA polymerase. [PDF]
Nat CommunThe plastid-encoded RNA polymerase serves as the principal transcription machinery within chloroplasts, transcribing over 80% of all primary plastid transcripts.
Wang T +8 more
europepmc +2 more sources
The architecture of RNA polymerase fidelity [PDF]
BMC Biology, 2010 The basis for transcriptional fidelity by RNA polymerase is not understood, but the 'trigger loop', a conserved structural element that is rearranged in the presence of correct substrate nucleotides, is thought to be critical.
Kaplan Craig D
doaj +4 more sources
Suppression by RNA Polymerase I Inhibitors Varies Greatly Between Distinct RNA Polymerase I Transcribed Genes in Malaria Parasites. [PDF]
PathogensThe transcription of ribosomal RNA (rRNA) by RNA Polymerase I (Pol I) is the rate-limiting step in ribosome biogenesis and a major determinant of cellular growth rates.
Samuel H +2 more
europepmc +2 more sources
Structural Biology of Bacterial RNA Polymerase
Biomolecules, 2015 Since its discovery and characterization in the early 1960s (Hurwitz, J. The discovery of RNA polymerase. J. Biol. Chem. 2005, 280, 42477–42485), an enormous amount of biochemical, biophysical and genetic data has been collected on bacterial RNA ...
Katsuhiko S. Murakami
doaj +2 more sources
Evolution of complex RNA polymerases: the complete archaeal RNA polymerase structure.
PLoS Biology, 2009 The archaeal RNA polymerase (RNAP) shares structural similarities with eukaryotic RNAP II but requires a reduced subset of general transcription factors for promoter-dependent initiation.
Yakov Korkhin +7 more
doaj +5 more sources
Structural basis of RNA polymerase complexes in African swine fever virus. [PDF]
Nat CommunAfrican swine fever virus is highly contagious and causes a fatal infectious disease in pigs, resulting in a significant global impact on pork supply.
Zhu G +25 more
europepmc +2 more sources
Abstract P-23: Histone N-terminal Tails Reduce Early Nucleosomal Pausing during Transcription [PDF]
International Journal of Biomedicine, 2021 Background: Nucleosomes are the barriers to transcript elongation by RNA polymerase 2 (Pol 2) in vitro and in vivo. Formation and overcoming the barrier are important for transcription regulation. N-terminal tails of core histones do not affect the inner
Nadezhda S. Gerasimova +2 more
doaj +1 more source