Results 221 to 230 of about 1,275,536 (291)

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

Natural degradation of RNA polymerase II is essential for oocyte chromatin reorganization and maternal-to-zygotic transition. [PDF]

Nat Commun
Wang J, Li W, Guo J, Xu X, Lin G, Li B, So C.   +6 more
europepmc   +1 more source

Sequence-independent upstream DNA–αCTD interactions strongly stimulate Escherichia coli RNA polymerase- lacUV5 promoter association

, 2004
Wilma Ross, Richard L. Gourse
openalex   +1 more source

Multiscale Hybrid Surface Topographies Orchestrate Immune Regulation, Antibacterial Defense, and Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Hybrid wrinkled topographies coordinate immune, tissue, and bacterial interactions. The surfaces promote osteointegration, tune macrophage polarization, and inhibit biofilm formation, highlighting a multifunctional strategy for next‐generation implant design.
Mohammad Asadi Tokmedash, Jacob Robins, J. Scott VanEpps, Minji Kim, Jouha Min   +4 more
wiley   +1 more source

Inhibitors of the hepatitis C virus RNA-dependent RNA polymerase

ARKIVOC, 2006
Barbara Attenni, Salvatore Avolio, Stefania Colarusso, Savina Malancona, Steven Harper, Sergio Altamura, Uwe Koch, Frank Narjes   +7 more
doaj   +1 more source

The neddylation of the RNA-dependent RNA polymerase 3D of Coxsackievirus B3 promotes viral replication. [PDF]

J Virol
Li S, Dong Y, Wang X, Feng D, Luan T, Wang Z, Lin L, Chen Y, Wang Y, Fei Y, Wang Y, Zhong Z, Zhao W.   +12 more
europepmc   +1 more source

Transcription pausing by Escherichia coli RNA polymerase is modulated by downstream DNA sequences.

, 1990
Donna N Lee, Le Dinh Phung, J Stewart, Robert Landick   +3 more
openalex   +1 more source

Development of a Synthetic 3D Platform for Compartmentalized Kidney In Vitro Disease Modeling

Advanced Healthcare Materials, EarlyView.
A fully synthetic, compartmentalized 3D kidney disease model is introduced. The kidney model combines a PEG‐based hydrogel matrix with anisotropic, enzymatically degradable rod‐shaped microgels to spatially arrange a triple co‐culture of key renal epithelial, endothelial, and fibroblast cells.
Ninon Möhl, Daphne Bouwens, Johanna Abele, Aline Hans, Tanja Topic, Daniel Günther, Jitske Jansen, Rafael Kramann, Laura De Laporte   +8 more
wiley   +1 more source

RNA polymerase II degradation triggered by DNA repair occurs in trans and independently of how the lesion is recognized. [PDF]

Nucleic Acids Res
Choudhary R, Muñoz JC, Beckerman I, Rebottaro ML, Bastianello G, Bouvier LA, Foiani M, Muñoz MJ.   +7 more
europepmc   +1 more source

Bioengineered Lymphatic Vessels in Synthetic Matrices to Study Breast Cancer Cell Functions

Advanced Healthcare Materials, EarlyView.
Lymphatic vessels are involved in cancer metastasis. To study the interplay between metastasizing cancer cells and lymphatic vessels under highly reproducible conditions, advanced in vitro models are required. In this work, 3D lymphatic networks are formed in biomimetic hydrogels and their interactions with invasive and non‐invasive cancer cell‐lines ...
Rodi Odabasi, Lisa A. Krattiger, Magdalini Kanari, Mira A. Jacobs, Lukas O. Moser, Mark W. Tibbitt, Cornelia Halin, Martin Ehrbar   +7 more
wiley   +1 more source