Results 241 to 250 of about 768,924 (317)

Chemotherapy‐Mediated Induction of PD‐L1 via SEI1 Facilitates Myeloma Immune Evasion

Advanced Science, EarlyView.
Chemotherapy induces DNA damage, activating cyclic guanosine monophosphate (GMP)‐adenosine monophosphate (AMP) synthase (cGAS)/stimulator of interferon genes (STING), which phosphorylates interferon regulatory factor 7 (IRF7) to drive SERTA‐containing domain 1 (SEI1) transcription.
Rui Chen, Zongwei Li, Zhihong Fang, Zou Li, Daoyan Yang, Yuan Li, Shurong Liu, Zhiqiang Liu, Rui Liu, Huan Liu   +9 more
wiley   +1 more source

Mechanisms of transcription attenuation and condensation of RNA polymerase II by RECQ5

Sebesta M, Skubnik K, Morton W, Kravec M, Linhartova K, Klapstova V, Novacek J, Kubicek K, Bryja V, Vacha R, Stefl R.   +10 more
europepmc   +1 more source

Computational analysis of the effect of a binding protein (RbpA) on the dynamics of Mycobacterium tuberculosis RNA polymerase assembly. [PDF]

PLoS One
Bheemireddy S, Sowdhamini R, Srinivasan N.   +2 more
europepmc   +1 more source

Gut Microbiota‐Butyrate‐PPARγ Axis Modulates Adipose Regulatory T Cell Population

Advanced Science, EarlyView.
This study identifies the indispensable role of gut microbiota in the maintenance of ST2+ adipose Treg cell population, and defines gut microbiota‐derived butyrate as an endogenous PPARγ agonist, modulating adipose Treg cell populations via promoting PPARγ activation. Butyrate or fiber supplementation restores the VAT ST2+ Treg population in obese mice
Banru Chen, Lizhi Guan, Chao Wu, Yiwen Gong, Lei Wu, Minchun Zhang, Zhiwen Cao, Yufei Chen, Chengcan Yang, Bing Wang, Yunqi Li, Bin Li, Yufang Bi, Guang Ning, Jiqiu Wang, Weiqing Wang, Ruixin Liu   +16 more
wiley   +1 more source

SSUP-72/PINN-1 coordinates RNA-polymerase II 3' pausing and developmental gene expression in C. elegans. [PDF]

Nat Commun
Stubbe FX, Ponsard P, Steiner FA, Hermand D.   +3 more
europepmc   +1 more source

SIRT3‐Mediated Deacetylation of DRP1K711 Prevents Mitochondrial Dysfunction in Parkinson's Disease

Advanced Science, EarlyView.
SIRT3‐mediated deacetylation of DRP1 at K711 resists mitochondrial dysfunction and DA neuronal death in PD, uncovering a treatment target. Abstract Dysregulation of mitochondrial dynamics is a key contributor to the pathogenesis of Parkinson's disease (PD).
Ye Xi, Kai Tao, Xiaomin Wen, Dayun Feng, Zifan Mai, Hui Ding, Honghui Mao, Mingming Wang, Qian Yang, Jie Xiang, Jie Zhang, Shengxi Wu   +11 more
wiley   +1 more source

TblncRNA-23, a long non-coding RNA transcribed by RNA polymerase I, regulates developmental changes in Trypanosoma brucei. [PDF]

Nat Commun
Galili-Kostin B, Rajan KS, Ida Ashkenazi Y, Freedman A, Doniger T, Cohen-Chalamish S, Waldman Ben-Asher H, Unger R, Roditi I, Tschudi C, Michaeli S.   +10 more
europepmc   +1 more source

Copy Number Gains of VPS72 Drive De Novo Lipogenesis and Hepatocarcinogenesis via ATF3/mTORC1/SREBP1 Axis

Advanced Science, EarlyView.
VPS72 overexpression activates mTORC1 signaling, subsequently promoting lipid synthesis and driving HCC progression. VPS72 modulates the epigenetic landscape of ATF3 promoter, such as H2A.Z acetylation reduction and DNA methylation increase, which results in ATF3 repression and subsequent activation of mTORC1.
Qinglin Zhang, Yunxing Huang, Yin Tong, Kenneth Tsz Chun Ng, Jiangwen Zhang   +4 more
wiley   +1 more source

Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters. [PDF]

Nat Commun
Shah SZ, Perry TN, Graziadei A, Cecatiello V, Kaliyappan T, Misiaszek AD, Müller CW, Ramsay EP, Vannini A.   +8 more
europepmc   +1 more source

Phosphorylation of yeast DNA-dependent RNA polymerases in vivo and in vitro. Isolation of enzymes and identification of phosphorylated subunits.

, 1977
Graeme I. Bell, Pablo Valenzuela, William J. Rutter   +2 more
openalex   +1 more source