Results 271 to 280 of about 2,633,578 (383)

Current biosensing strategies based on in vitro T7 RNA polymerase reaction. [PDF]

open access: yesBiotechnol Notes
Sumanto Marpaung DS   +4 more
europepmc   +1 more source

Emerging Therapeutic Strategies for Hearing Loss

open access: yesAdvanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han   +9 more
wiley   +1 more source

Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2016
B. Shu, P. Gong
semanticscholar   +1 more source

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

open access: yesAdvanced Theory and Simulations, EarlyView.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak   +2 more
wiley   +1 more source

Structural insights into promoter-proximal pausing of RNA polymerase II at +1 nucleosome. [PDF]

open access: yesSci Adv
Naganuma M   +11 more
europepmc   +1 more source

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

open access: yesAdvanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang   +14 more
wiley   +1 more source

T7 RNA polymerase-guided base editor for accelerated continuous evolution in <i>Bacillus subtilis</i>. [PDF]

open access: yesSynth Syst Biotechnol
Wang B   +7 more
europepmc   +1 more source

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