Results 21 to 30 of about 2,706,723 (382)

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

Journal of Biological Chemistry, 2020
Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to control this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Calvin J. Gordon, E. Tchesnokov, E. Woolner, Jason K. Perry, Joy Y. Feng, D. Porter, M. Götte   +6 more
semanticscholar   +1 more source

Contractions of the C-Terminal Domain of Saccharomyces cerevisiae Rpb1p Are Mediated by Rad5p

G3: Genes, Genomes, Genetics, 2020
The C-terminal domain (CTD) is an essential domain of the largest subunit of RNA polymerase II, Rpb1p, and is composed of 26 tandem repeats of a seven-amino acid sequence, YSPTSPS.
Taylor Stewart, Alexandra E. Exner, Paras Patnaik, Stephen M. Fuchs   +3 more
doaj   +1 more source

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

Journal of Biological Chemistry, 2020
Antiviral drugs for managing infections with human coronaviruses are not yet approved, posing a serious challenge to current global efforts aimed at containing the outbreak of severe acute respiratory syndrome–coronavirus 2 (CoV-2).
Calvin J. Gordon, E. Tchesnokov, Joy Y. Feng, D. Porter, M. Götte   +4 more
semanticscholar   +1 more source

A roadmap for designing narrow-spectrum antibiotics targeting bacterial pathogens

Microbial Cell, 2022
Clostridioides difficile (Cdiff) infection (CDI) continues to be the leading threat of nosocomial deaths worldwide and a major burden on health-care systems.
Xinyun Cao, Robert Landick, Elizabeth A. Campbell   +2 more
doaj   +1 more source

Investigating the role of RNA structures in transcriptional pausing using in vitro assays and in silico analyses

RNA Biology, 2022
Transcriptional pausing occurs across the bacterial genome but the importance of this mechanism is still poorly understood. Only few pauses were observed during the previous decades, leaving an important gap in understanding transcription mechanisms ...
Simon Jeanneau, Pierre-Étienne Jacques, Daniel A. Lafontaine   +2 more
doaj   +1 more source

Transcription-translation coupling: direct interactions of RNA polymerase with ribosomes and ribosomal subunits. [PDF]

, 2017
In prokaryotes, RNA polymerase and ribosomes can bind concurrently to the same RNA transcript, leading to the functional coupling of transcription and translation.
Blaha, Gregor M, Conn, Adam B, Diggs, Stephen, Fan, Haitian, Gamper, Howard B, Hahm, Joseph, Hou, Ya-Ming, O'Leary, Seán E, Wang, Yinsheng, Williams, Preston B   +9 more
core   +1 more source

Gene Transcription as a Limiting Factor in Protein Production and Cell Growth

G3: Genes, Genomes, Genetics, 2020
Cell growth is driven by the synthesis of proteins, genes, and other cellular components. Defining processes that limit biosynthesis rates is fundamental for understanding the determinants of cell physiology.
Eyal Metzl-Raz, Moshe Kafri, Gilad Yaakov, Naama Barkai   +3 more
doaj   +1 more source

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Science, 2020
A wrench in the works of COVID-19 Understanding the inner workings of the virus that causes coronavirus disease 2019 (COVID-19) may help us to disrupt it. Yin et al. focused on the viral polymerase essential for replicating viral RNA.
W. Yin, W. Yin, C. Mao, Xiaodong Luan, Xiaodong Luan, D. Shen, Qingya Shen, H. Su, Xiao-xi Wang, F. Zhou, Wenfeng Zhao, M. Gao, Shenghai Chang, Yuan Chao Xie, Guanghui Tian, He wei Jiang, Sheng-ce Tao, Jingshan Shen, Yi Jiang, Hualiang Jiang, Yechun Xu, Shuyang Zhang, Shuyang Zhang, Yan Zhang, H. E. Xu   +24 more
semanticscholar   +1 more source

Spt5 Cooperates with Human Immunodeficiency Virus Type 1 Tat by Preventing Premature RNA Release at Terminator Sequences [PDF]

, 2002
The human immunodeficiency virus type 1 (HIV-1) Tat protein activates transcription elongation by stimulating the Tat-activated kinase (TAK/p-TEFb), a protein kinase composed of CDK9 and its cyclin partner, cyclin T1.
Bourgeois, Cyril F, Churcher, Mark J, Karn, Jonathan, Kim, Young Kyeung, West, Michelle J   +4 more
core   +3 more sources

Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

Nature Communications, 2020
The ongoing Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emphasized the urgent need for antiviral therapeutics.
A. Shannon, B. Selisko, N. Le, Johanna Huchting, F. Touret, G. Piorkowski, Véronique Fattorini, F. Ferron, E. Decroly, C. Meier, B. Coutard, O. Peersen, B. Canard   +12 more
semanticscholar   +1 more source