Results 21 to 30 of about 2,625,316 (382)

Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance While the current COVID-19 pandemic continues, the US Food and Drug Administration (FDA) has approved only one drug against the virus—remdesivir.
K. Naydenova, K. W. Muir, Long-Fei Wu, Ziguo Zhang, F. Coscia, M. Peet, P. Castro-Hartmann, P. Qian, K. Sader, Kyle C. Dent, D. Kimanius, J. Sutherland, J. Löwe, D. Barford, C. Russo   +14 more
semanticscholar   +1 more source

Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

bioRxiv, 2020
The pandemic of Corona Virus Disease 2019 (COVID-19) caused by SARS-CoV-2 has become a global crisis. The replication of SARS-CoV-2 requires the viral RNA-dependent RNA polymerase (RdRp), a direct target of the antiviral drug, Remdesivir.
W. Yin, C. Mao, X. Luan, D. Shen, Q. Shen, H. Su, Xiao-xi Wang, F. Zhou, Wenfeng Zhao, M. Gao, Shenghai Chang, Yuanchao Xie, Guanghui Tian, He-wei Jiang, S. Tao, Jingshan Shen, Yi Jiang, Hualiang Jiang, Yechun Xu, Shuyang Zhang, Yan Zhang, H. Eric Xu   +21 more
semanticscholar   +1 more source

Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant

Journal of Translational Medicine, 2020
Background SARS-CoV-2 is a RNA coronavirus responsible for the pandemic of the Severe Acute Respiratory Syndrome (COVID-19). RNA viruses are characterized by a high mutation rate, up to a million times higher than that of their hosts.
M. Pachetti, B. Marini, F. Benedetti, F. Giudici, E. Mauro, P. Storici, C. Masciovecchio, S. Angeletti, M. Ciccozzi, R. Gallo, D. Zella, R. Ippodrino   +11 more
semanticscholar   +1 more source

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

Journal of Biological Chemistry, 2020
Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to control this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Calvin J. Gordon, E. Tchesnokov, E. Woolner, Jason K. Perry, Joy Y. Feng, D. Porter, M. Götte   +6 more
semanticscholar   +1 more source

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

Journal of Biological Chemistry, 2020
Antiviral drugs for managing infections with human coronaviruses are not yet approved, posing a serious challenge to current global efforts aimed at containing the outbreak of severe acute respiratory syndrome–coronavirus 2 (CoV-2).
Calvin J. Gordon, E. Tchesnokov, Joy Y. Feng, D. Porter, M. Götte   +4 more
semanticscholar   +1 more source

Contractions of the C-Terminal Domain of Saccharomyces cerevisiae Rpb1p Are Mediated by Rad5p

G3: Genes, Genomes, Genetics, 2020
The C-terminal domain (CTD) is an essential domain of the largest subunit of RNA polymerase II, Rpb1p, and is composed of 26 tandem repeats of a seven-amino acid sequence, YSPTSPS.
Taylor Stewart, Alexandra E. Exner, Paras Patnaik, Stephen M. Fuchs   +3 more
doaj   +1 more source

Investigating the role of RNA structures in transcriptional pausing using in vitro assays and in silico analyses

RNA Biology, 2022
Transcriptional pausing occurs across the bacterial genome but the importance of this mechanism is still poorly understood. Only few pauses were observed during the previous decades, leaving an important gap in understanding transcription mechanisms ...
Simon Jeanneau, Pierre-Étienne Jacques, Daniel A. Lafontaine   +2 more
doaj   +1 more source

A roadmap for designing narrow-spectrum antibiotics targeting bacterial pathogens

Microbial Cell, 2022
Clostridioides difficile (Cdiff) infection (CDI) continues to be the leading threat of nosocomial deaths worldwide and a major burden on health-care systems.
Xinyun Cao, Robert Landick, Elizabeth A. Campbell   +2 more
doaj   +1 more source

Transcription-translation coupling: direct interactions of RNA polymerase with ribosomes and ribosomal subunits. [PDF]

, 2017
In prokaryotes, RNA polymerase and ribosomes can bind concurrently to the same RNA transcript, leading to the functional coupling of transcription and translation.
Blaha, Gregor M, Conn, Adam B, Diggs, Stephen, Fan, Haitian, Gamper, Howard B, Hahm, Joseph, Hou, Ya-Ming, O'Leary, Seán E, Wang, Yinsheng, Williams, Preston B   +9 more
core   +1 more source

Gene Transcription as a Limiting Factor in Protein Production and Cell Growth

G3: Genes, Genomes, Genetics, 2020
Cell growth is driven by the synthesis of proteins, genes, and other cellular components. Defining processes that limit biosynthesis rates is fundamental for understanding the determinants of cell physiology.
Eyal Metzl-Raz, Moshe Kafri, Gilad Yaakov, Naama Barkai   +3 more
doaj   +1 more source