Results 21 to 30 of about 2,730,472 (338)

Gene Transcription as a Limiting Factor in Protein Production and Cell Growth

G3: Genes, Genomes, Genetics, 2020
Cell growth is driven by the synthesis of proteins, genes, and other cellular components. Defining processes that limit biosynthesis rates is fundamental for understanding the determinants of cell physiology.
Eyal Metzl-Raz, Moshe Kafri, Gilad Yaakov, Naama Barkai   +3 more
doaj   +1 more source

Investigating the role of RNA structures in transcriptional pausing using in vitro assays and in silico analyses

RNA Biology, 2022
Transcriptional pausing occurs across the bacterial genome but the importance of this mechanism is still poorly understood. Only few pauses were observed during the previous decades, leaving an important gap in understanding transcription mechanisms ...
Simon Jeanneau, Pierre-Étienne Jacques, Daniel A. Lafontaine   +2 more
doaj   +1 more source

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Science, 2020
A wrench in the works of COVID-19 Understanding the inner workings of the virus that causes coronavirus disease 2019 (COVID-19) may help us to disrupt it. Yin et al. focused on the viral polymerase essential for replicating viral RNA.
W. Yin, W. Yin, C. Mao, Xiaodong Luan, Xiaodong Luan, D. Shen, Qingya Shen, H. Su, Xiao-xi Wang, F. Zhou, Wenfeng Zhao, M. Gao, Shenghai Chang, Yuan Chao Xie, Guanghui Tian, He wei Jiang, Sheng-ce Tao, Jingshan Shen, Yi Jiang, Hualiang Jiang, Yechun Xu, Shuyang Zhang, Shuyang Zhang, Yan Zhang, H. E. Xu   +24 more
semanticscholar   +1 more source

A comparative study of DNA-dependent RNA polymerases from rat ascites hepatoma cell nuclei and from rat liver nuclei [PDF]

, 1975
DNA-dependent RNA polymerases (EC 2.7.7.6) were extracted and partially purified form the nuclei of rat ascites hepatoma cells (AH-130) induced by 4-dimethylaminoazobenzene.
Misumi, Hiromasa
core   +1 more source

Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

Nature Communications, 2020
The ongoing Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emphasized the urgent need for antiviral therapeutics.
A. Shannon, B. Selisko, N. Le, Johanna Huchting, F. Touret, G. Piorkowski, Véronique Fattorini, F. Ferron, E. Decroly, C. Meier, B. Coutard, O. Peersen, B. Canard   +12 more
semanticscholar   +1 more source

Iterative chemostat: A modelling framework linking biosynthesis to nutrient cycling on ecological and evolutionary time scales

Mathematical Biosciences and Engineering, 2019
In the classical chemostat, the output of the system has no effect on its input. This contrasts with many ecological systems, where the output at the end of a growing season affects nutrient inputs for subsequent seasons.
Irakli Loladze
doaj   +1 more source

RNA Unwinding by the Trf4/Air2/Mtr4 Polyadenylation (TRAMP) Complex [PDF]

, 2012
Many RNA-processing events in the cell nucleus involve the Trf4/Air2/Mtr4 polyadenylation (TRAMP) complex, which contains the poly(A) polymerase Trf4p, the Zn-knuckle protein Air2p, and the RNA helicase Mtr4p.
Anderson, James T., Jankowsky, Eckhard, Jia, Huijue, Wang, Xuying   +3 more
core   +2 more sources

Spt5 Cooperates with Human Immunodeficiency Virus Type 1 Tat by Preventing Premature RNA Release at Terminator Sequences [PDF]

, 2002
The human immunodeficiency virus type 1 (HIV-1) Tat protein activates transcription elongation by stimulating the Tat-activated kinase (TAK/p-TEFb), a protein kinase composed of CDK9 and its cyclin partner, cyclin T1.
Bourgeois, Cyril F, Churcher, Mark J, Karn, Jonathan, Kim, Young Kyeung, West, Michelle J   +4 more
core   +3 more sources

RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery

SLAS Discovery, 2020
COVID-19 respiratory disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has rapidly become a global health issue since it emerged in December 2019.
Wei Zhu, Catherine Z. Chen, Kirill Gorshkov, Miao Xu, D. Lo, Wei Zheng   +5 more
semanticscholar   +1 more source

Regulation of Eukaryotic RNAPs Activities by Phosphorylation

Frontiers in Molecular Biosciences, 2021
Evolutionarily conserved kinases and phosphatases regulate RNA polymerase II (RNAPII) transcript synthesis by modifying the phosphorylation status of the carboxyl-terminal domain (CTD) of Rpb1, the largest subunit of RNAPII.
Araceli González-Jiménez, Adrián Campos, Francisco Navarro, Francisco Navarro, Andrés Clemente-Blanco, Olga Calvo   +5 more
doaj   +1 more source