Results 331 to 340 of about 2,760,256 (386)

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Anti-RNA polymerase III antibodies in systemic sclerosis: prevalence and clinical associations from a systematic review and meta-analysis. [PDF]

Rheumatology (Oxford)
Elhannani A, Martel ME, Collet A, Chepy A, Sanges S, Hachulla É, Dubucquoi S, Launay D, Sobanski V.   +8 more
europepmc   +1 more source

Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang, Jianbo Huang, Shuwei Zhang, Sujiao Cao, Fangxue Du, Liqiang Zhou, Li Qiu, Yuanjiao Tang   +7 more
wiley   +1 more source

LAIV Mutations Selectively Alter Influenza Viral RNA Polymerase Function, Favoring Transcription over Genome Synthesis. [PDF]

Viruses
Leach JR, Oo A, Nogales A, Bosch SI, Martínez-Sobrido L, Feng C, Kim B, Dewhurst S.   +7 more
europepmc   +1 more source

Structures of <i>Vibrio cholerae</i> transcription complexes reveal how ToxR and TcpP recruit the RNA polymerase and activate virulence genes. [PDF]

Sci Adv
Alcaide-Jiménez A, Canals A, Baudin F, Machón C, Fàbrega-Ferrer M, Bantysh O, Pérez-Luque R, Murciano B, Mohammad AA, Rowse MJ, Ferracciolo JM, Krukonis ES, Müller CW, Coll M.   +13 more
europepmc   +1 more source

Gene expression analysis and proximity labeling reveal post-transcriptional functions of the yeast RNA polymerase II regulator Def1. [PDF]

J Biol Chem
Akinniyi OT, Kulkarni S, Hribal MM, Keller CA, Giardine BM, Reese JC.   +5 more
europepmc   +1 more source

Pleomorphic effects of three small-molecule inhibitors on transcription elongation by <i>Mycobacterium tuberculosis</i> RNA polymerase. [PDF]

Elife
Herrera-Asmat O, Tong AB, Lin W, Kong T, Del Valle JR, Guerra DG, Ebright YW, Ebright RH, Bustamante C.   +8 more
europepmc   +1 more source

Repurposing FDA-Approved Drugs as Hendra Virus RNA-Dependent RNA Polymerase Inhibitors: A Comprehensive Computational Drug Discovery Approach. [PDF]

Viruses
Lalu AC, Kundil VT, Joseph BB, Dev RR, Thaikkad A, Subair S, Raju R, Jayanandan A.   +7 more
europepmc   +1 more source

RNA Polymerase III Promoters Compatible with CRISPR Gene Regulation in <i>Saccharomyces cerevisiae</i>. [PDF]

ACS Synth Biol
Holland KL, Blancher I, McKesey M, Silas M, Gandhi S, Nickerson A, Jackson K, Blazeck J.   +7 more
europepmc   +1 more source

Restrictor slows early transcription elongation to render RNA polymerase II susceptible to termination at non-coding RNA loci

Claudia A. Mimoso, Hanneke Vlaming, Nathalie P. de Wagenaar, Karen Adelman   +3 more
openalex   +1 more source