Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir
Viruses, 2019 Remdesivir (GS-5734) is a 1′-cyano-substituted adenosine nucleotide analogue prodrug that shows broad-spectrum antiviral activity against several RNA viruses. This compound is currently under clinical development for the treatment of Ebola virus disease (
E. Tchesnokov +3 more
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An RNA polymerase ribozyme that synthesizes its own ancestor
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Life depends on the propagation of heritable information across successive generations. An RNA polymerase ribozyme was obtained by in vitro evolution that has an unprecedented level of activity in copying complex RNA templates.
Katrina F. Tjhung +3 more
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The largest subunit of human RNA polymerase III is closely related to the largest subunit of yeast and trypanosome RNA polymerase III [PDF]
, 1997 In both yeast and mammalian systems, considerable progress has been made toward the characterization of the transcription factors required for transcription by RNA polymerase III. However, whereas in yeast all of the RNA polymerase III subunits have been
Hernandez, N., Sepehri, S.
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RNA polymerase interactions and elongation rate
, 2018 We show that non-steric molecular interactions between RNA polymerase (RNAP) motors that move simultaneously on the same DNA track determine strongly the kinetics of transcription elongation.
Belitsky, V., Schütz, G. M.
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Syn5 RNA polymerase synthesizes precise run-off RNA products [PDF]
, 2013 The enzyme predominantly used for in vitro run-off RNA synthesis is bacteriophage T7 RNA polymerase. T7 RNA polymerase synthesizes, in addition to run-off products of precise length, transcripts with an additional non-base-paired nucleotide at the 3 ...
Richardson, Charles C. +2 more
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Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase
Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2017 Favipiravir (T-705; 6-fluoro-3-hydroxy-2-pyrazinecarboxamide) is an anti-viral agent that selectively and potently inhibits the RNA-dependent RNA polymerase (RdRp) of RNA viruses.
Y. Furuta, T. Komeno, Takaaki Nakamura
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Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates
Nature Communications, 2020 The etiologic agent of the Covid-19 pandemic is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The viral membrane of SARS-CoV-2 surrounds a helical nucleocapsid in which the viral genome is encapsulated by the nucleocapsid protein. The
A. Savastano +3 more
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Frontiers in Bioscience-LandmarkAccurate gene expression is fundamental for sustaining life, enabling adaptive responses to routine tasks and management of urgent cellular environments.
Jihye Ryu, Chaeyoung Lee
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Origin and Evolution of RNA-Dependent RNA Polymerase
Frontiers in Genetics, 2017 RNA-dependent RNA polymerases (RdRp) are very ancient enzymes and are essential for all viruses with RNA genomes. We reconstruct the origin and evolution of this polymerase since the initial stages of the origin of life. The origin of the RdRp was traced
Savio T. de Farias +3 more
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Activation of σ28-dependent transcription inEscherichia coliby the cyclic AMP receptor protein requires an unusual promoter organization [PDF]
, 2010 The Escherichia coli aer regulatory region contains a single promoter that is recognized by RNA polymerase containing the flagellar sigma factor, σ28.
Busby, Stephen J. W. +3 more
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