Results 41 to 50 of about 2,226,379 (341)
Amplification of RNA by an RNA polymerase ribozyme [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance Darwinian life requires the ability to replicate genotypes and express phenotypes. Although all extant life relies on protein enzymes to accomplish these tasks, life in the ancestral RNA world would have used only RNA enzymes. Here, we report the in vitro evolution of an improved RNA polymerase ribozyme that is able to synthesize
David P Horning, G. F. Joyce
semanticscholar +3 more sources
Mathematical Biosciences and Engineering, 2019 In the classical chemostat, the output of the system has no effect on its input. This contrasts with many ecological systems, where the output at the end of a growing season affects nutrient inputs for subsequent seasons.
Irakli Loladze
doaj +1 more source
RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery
SLAS Discovery, 2020 COVID-19 respiratory disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has rapidly become a global health issue since it emerged in December 2019.
Wei Zhu +5 more
semanticscholar +1 more source
RNA Polymerase III, Ageing and Longevity
Frontiers in Genetics, 2021 Transcription in eukaryotic cells is performed by three RNA polymerases. RNA polymerase I synthesises most rRNAs, whilst RNA polymerase II transcribes all mRNAs and many non-coding RNAs. The largest of the three polymerases is RNA polymerase III (Pol III)
Yavuz Kulaberoglu +5 more
doaj +1 more source
Nucleolar RNA polymerase II drives ribosome biogenesis
Nature, 2020 Proteins are manufactured by ribosomes—macromolecular complexes of protein and RNA molecules that are assembled within major nuclear compartments called nucleoli 1 , 2 .
K. Abraham +24 more
semanticscholar +1 more source
Regulation of Eukaryotic RNAPs Activities by Phosphorylation
Frontiers in Molecular Biosciences, 2021 Evolutionarily conserved kinases and phosphatases regulate RNA polymerase II (RNAPII) transcript synthesis by modifying the phosphorylation status of the carboxyl-terminal domain (CTD) of Rpb1, the largest subunit of RNAPII.
Araceli González-Jiménez +5 more
doaj +1 more source
Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates
Nature Communications, 2020 The etiologic agent of the Covid-19 pandemic is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The viral membrane of SARS-CoV-2 surrounds a helical nucleocapsid in which the viral genome is encapsulated by the nucleocapsid protein. The
A. Savastano +3 more
semanticscholar +1 more source
Mediator and RNA polymerase II clusters associate in transcription-dependent condensates
Science, 2018 Phase separation and gene control Many components of eukaryotic transcription machinery—such as transcription factors and cofactors including BRD4, subunits of the Mediator complex, and RNA polymerase II—contain intrinsically disordered low-complexity ...
W. Cho +6 more
semanticscholar +1 more source
RNA Polymerase-Promoter Interactions: the Comings and Goings of RNA Polymerase [PDF]
Journal of Bacteriology, 1998 Initiation of transcription is a complicated process involving several different phases: promoter location by RNA polymerase, formation of a competent initiation complex, synthesis of the initial phosphodiester bonds, and movement of RNA polymerase from the promoter as it enters the elongation ...
Margaret L. Zupancic +2 more
openaire +3 more sources
N4 RNA Polymerase II, a Heterodimeric RNA Polymerase with Homology to the Single-Subunit Family of RNA Polymerases [PDF]
Journal of Bacteriology, 2002 ABSTRACTBacteriophage N4 middle genes are transcribed by a phage-coded, heterodimeric, rifampin-resistant RNA polymerase, N4 RNA polymerase II (N4 RNAPII). Sequencing and transcriptional analysis revealed that the genes encoding the two subunits comprising N4 RNAPII are translated from a common transcript initiating at the N4 early promoter Pe3.
R. H. Carter +3 more
openaire +3 more sources