Results 1 to 10 of about 1,401,767 (284)

Structure of the human RNA polymerase I elongation complex. [PDF]

Cell Discov, 2021
Eukaryotic RNA polymerase I (Pol I) transcribes ribosomal DNA and generates RNA for ribosome synthesis. Pol I accounts for the majority of cellular transcription activity and dysregulation of Pol I transcription leads to cancers and ribosomopathies ...
Zhao D, Liu W, Chen K, Wu Z, Yang H, Xu Y.   +5 more
europepmc   +8 more sources

Conserved strategies of RNA polymerase I hibernation and activation. [PDF]

Nat Commun, 2021
RNA polymerase (Pol) I transcribes the ribosomal RNA precursor in eukaryotes. Here, the authors present three cryo-EM structure of S. pombe Pol I in different functional states among them a dimer structure and discuss conserved and organism-specific ...
Heiss FB, Daiß JL, Becker P, Engel C.
europepmc   +7 more sources

Suppression by RNA Polymerase I Inhibitors Varies Greatly Between Distinct RNA Polymerase I Transcribed Genes in Malaria Parasites. [PDF]

Pathogens
The transcription of ribosomal RNA (rRNA) by RNA Polymerase I (Pol I) is the rate-limiting step in ribosome biogenesis and a major determinant of cellular growth rates.
Samuel H, Campelo Morillo R, Kafsack BFC.   +2 more
europepmc   +2 more sources

TBP facilitates RNA Polymerase I transcription following mitosis. [PDF]

RNA Biol
The TATA-box binding protein (TBP) is the sole transcription factor common in the initiation complexes of the three major eukaryotic RNA Polymerases (Pol I, II and III).
Kwan JZJ, Nguyen TF, Teves SS.
europepmc   +2 more sources

Regulation of RNA Polymerase I Stability and Function. [PDF]

Cancers (Basel), 2022
RNA polymerase I is a highly processive enzyme with fast initiation and elongation rates. The structure of Pol I, with its in-built RNA cleavage ability and incorporation of subunits homologous to transcription factors, enables it to quickly and efficiently synthesize the enormous amount of rRNA required for ribosome biogenesis.
Pitts S, Laiho M.
europepmc   +3 more sources

Loss of Proteostasis Is a Pathomechanism in Cockayne Syndrome [PDF]

Cell Reports, 2018
Retarded growth and neurodegeneration are hallmarks of the premature aging disease Cockayne syndrome (CS). Cockayne syndrome proteins take part in the key step of ribosomal biogenesis, transcription of RNA polymerase I.
Adrian Schelling, Francesca Tuorto, Ioanna Krikki, Karin Scharffetter-Kochanek, Lorenzo Montanaro, Marianna Penzo, Marius Costel Alupei, Pallab Maity, Philipp Ralf Esser, Rosanna Parlato, Sebastian Iben, Vincent Laugel   +11 more
core   +6 more sources

TFIIH is an elongation factor of RNA polymerase I [PDF]

Nucleic Acids Research, 2011
TFIIH is a multisubunit factor essential for transcription initiation and promoter escape of RNA polymerase II and for the opening of damaged DNA double strands in nucleotide excision repair (NER).
Adrian Schelling, Anton Lebedev, Bradsher, Bradsher, Cleaver, Coin, Comai, de Boer, Deisenroth, Dianov, Dignam, Douziech, Drane, Dvir, Garinis, Guzder, Hoeijmakers, Hoogstraten, Hwang, Iben, Ito, Kim, Laposa, Lebedev, Lin, Lobo, Lutomska, O'Sullivan, Oh, Oksenych, Omar Garcia Gonzalez, Panov, Robin Assfalg, Rubbi, Schneider, Sebastian Iben, Sylvia Koch, Weeda, Weinmann, Yu, Yuan, Yuan   +41 more
core   +6 more sources

RNA polymerase I mutant affects ribosomal RNA processing and ribosomal DNA stability. [PDF]

RNA Biol
Transcription is a major contributor to genomic instability. The ribosomal RNA (rDNA) gene locus consists of a head-to-tail repeat of the most actively transcribed genes in the genome.
Normand C, Dez C, Dauban L, Queille S, Danché S, Abderrahmane S, Beckouet F, Gadal O.   +7 more
europepmc   +2 more sources

Expression of RNA polymerase I catalytic core is influenced by RPA12. [PDF]

PLoS One, 2023
RNA Polymerase I (Pol I) has recently been recognized as a cancer therapeutic target. The activity of this enzyme is essential for ribosome biogenesis and is universally activated in cancers.
Ford BL, Wei T, Liu H, Scull CE, Najmi SM, Pitts S, Fan W, Schneider DA, Laiho M.   +8 more
europepmc   +2 more sources

In vitro Assessment of RNA Polymerase I Activity

Bio-Protocol, 2017
In eukaryotic cells transcriptional processes are carried out by three different RNA polymerases: RNA polymerase I which specifically transcribes ribosomal RNA (rRNA), RNA polymerase II which transcribes protein-coding genes to yield messenger RNAs ...
Marzia Govoni
doaj   +5 more sources