Structure of the human RNA polymerase I elongation complex [PDF]
Cell Discovery, 2021 Eukaryotic RNA polymerase I (Pol I) transcribes ribosomal DNA and generates RNA for ribosome synthesis. Pol I accounts for the majority of cellular transcription activity and dysregulation of Pol I transcription leads to cancers and ribosomopathies ...
Dan Zhao +5 more
doaj +7 more sources
Conserved strategies of RNA polymerase I hibernation and activation [PDF]
Nature Communications, 2021 RNA polymerase (Pol) I transcribes the ribosomal RNA precursor in eukaryotes. Here, the authors present three cryo-EM structure of S. pombe Pol I in different functional states among them a dimer structure and discuss conserved and organism-specific ...
Florian B. Heiss +3 more
doaj +7 more sources
Suppression by RNA Polymerase I Inhibitors Varies Greatly Between Distinct RNA Polymerase I Transcribed Genes in Malaria Parasites [PDF]
PathogensThe transcription of ribosomal RNA (rRNA) by RNA Polymerase I (Pol I) is the rate-limiting step in ribosome biogenesis and a major determinant of cellular growth rates.
Hermela Samuel +2 more
doaj +2 more sources
Expression of RNA polymerase I catalytic core is influenced by RPA12. [PDF]
PLoS ONE, 2023 RNA Polymerase I (Pol I) has recently been recognized as a cancer therapeutic target. The activity of this enzyme is essential for ribosome biogenesis and is universally activated in cancers.
Brittany L Ford +8 more
doaj +2 more sources
TBP facilitates RNA Polymerase I transcription following mitosis [PDF]
RNA BiologyThe TATA-box binding protein (TBP) is the sole transcription factor common in the initiation complexes of the three major eukaryotic RNA Polymerases (Pol I, II and III).
James Z.J. Kwan +2 more
doaj +2 more sources
RNA polymerase I mutant affects ribosomal RNA processing and ribosomal DNA stability [PDF]
RNA BiologyTranscription is a major contributor to genomic instability. The ribosomal RNA (rDNA) gene locus consists of a head-to-tail repeat of the most actively transcribed genes in the genome.
Christophe Normand +7 more
doaj +2 more sources
Research Note: Establishment of vector system harboring duck RNA polymerase I promoter for avian influenza virus [PDF]
Poultry ScienceReverse genetics (RG) systems are extensively utilized to investigate the characteristics of influenza viruses and develop vaccines, predominantly relying on human RNA polymerase I (pol I). However, the efficiency of RG systems for avian-origin influenza
Yunyueng Jang +7 more
doaj +2 more sources
The conserved RNA-binding protein Seb1 promotes cotranscriptional ribosomal RNA processing by controlling RNA polymerase I progression [PDF]
Nature Communications, 2023 Transcription by RNA polymerase I (RNAPI) represents most of the transcriptional activity in eukaryotic cells and is associated with the production of mature ribosomal RNA (rRNA).
Maxime Duval +5 more
doaj +2 more sources
TblncRNA-23, a long non-coding RNA transcribed by RNA polymerase I, regulates developmental changes in Trypanosoma brucei [PDF]
Nature CommunicationsThe protozoan parasite Trypanosoma brucei undergoes a complex life cycle, moving between its mammalian host and the blood-feeding tsetse fly vector. The two major surface proteins expressed by procyclic forms in the insect midgut, EP and GPEET procyclin,
Beathrice Galili-Kostin +10 more
doaj +2 more sources
Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions [PDF]
Nature CommunicationsDuring synthesis of the ribosomal RNA precursor, RNA polymerase I (Pol I) monitors DNA integrity but its response to DNA damage remains poorly studied.
Alicia Santos-Aledo +8 more
doaj +2 more sources