Structural attributes of nucleotide sequences in promoter regions of supercoiling-sensitive genes: how to relate microarray expression data with genomic sequences [PDF]
, 2012 The level of supercoiling in the chromosome can affect gene expression. To clarify the basis of supercoiling sensitivity, we analyzed the structural features of nucleotide sequences in the vicinity of promoters for the genes with expression enhanced and decreased in response to loss of chromosomal supercoiling in E. coli.
arxiv +1 more source
Protein-Nucleic Acid Interactions in Nuclease and Polymerases [PDF]
, 2011 DNA polymerase binds to the double stranded DNA and extends the primer strand by adding deoxyribonucletide to the 3’-end. Several reactions in the polymerase active site have been reported by Kornberg in addition to the polymerization.
rob, abdur
core +1 more source
Architecture of eukaryotic mRNA 3' end processing machinery and insights into the mechanism of polyadenylation [PDF]
, 2019 Almost all eukaryotic messenger RNAs (mRNAs) have a polyadenosine (polyA) tail at their 3′ end that is added by a multi-protein complex known as cleavage and polyadenylation factor (CPF). CPF, along with accessory cleavage factors (CF) IA and IB, cleaves
Kumar, Ananthanarayanan
core +1 more source
PLoS ONEThroughout all domains of life, RNA polymerases (Pols) synthesize RNA from DNA templates, a process called transcription. During transcription, Pols require divalent metal cations for nucleotide addition and cleavage of the nascent RNA after ...
Abigail K Huffines, David A Schneider
doaj +1 more source
Fibrillarin methylates H2A in RNA polymerase I trans-active promoters in Brassica oleracea
Frontiers in Plant Science, 2015 Fibrillarin is a well conserved methyltransferase involved in several if not all of the more than 100 methylations sites in rRNA which are essential for proper ribosome function.
lloyd eLoza-Muller +5 more
doaj +1 more source
Genes & Development, 1998 Saccharomyces cerevisiae carries approximately 150 copies of rDNA in tandem repeats. It was found that the absence of an essential subunit of RNA polymerase I (Pol I) in rpa135 deletion mutants triggers a gradual decrease in rDNA repeat number to about ...
Takehiko Kobayashi +3 more
semanticscholar +1 more source
Migration of rat RNA polymerase I into chick erythrocyte nuclei undergoing reactivation in chick-rat heterokaryons [PDF]
, 1983 Transcriptionally inactive chick erythrocyte nudei were reactivated by Sendai virusinduced fusion of erythrocytes with rat L6j1 myoblasts. We used antibodies to trace the appearance of a specific protein engaged in transcription of a defined dass of ...
Franke, Werner W. +4 more
core
Results and Limitations of the Soliton Theory of DNA Transcription [PDF]
Journal of Biological Physics 24 (1999), 81-96, 2003 It has been suggested by several authors that nonlinear excitations, in particular solitary waves, could play a fundamental functional role in the process of DNA transcription, effecting the opening of the double chain needed for RNA Polymerase to be able to copy the genetic code.
arxiv
Regulation of Ribosomal RNA Production by RNA Polymerase I: Does Elongation Come First? [PDF]
, 2012 Ribosomal RNA (rRNA) production represents the most active transcription in the cell. Synthesis of the large rRNA precursors (35–47S) can be achieved by up to 150 RNA polymerase I (Pol I) enzymes simultaneously transcribing each rRNA gene. In this paper,
Albert, Benjamin +3 more
core +3 more sources
Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington’s disease
Scientific Reports, 2017 PGC-1α is a versatile inducer of mitochondrial biogenesis and responsive to the changing energy demands of the cell. As mitochondrial ATP production requires proteins that derive from translation products of cytosolic ribosomes, we asked whether PGC-1α ...
Sarah Jesse +14 more
doaj +1 more source