Results 221 to 230 of about 1,002,934 (332)

Cryo-EM structures of human RNA polymerase I. [PDF]

Nat Struct Mol Biol, 2021
Misiaszek AD, Girbig M, Grötsch H, Baudin F, Murciano B, Lafita A, Müller CW.   +6 more
europepmc   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

The interaction between σ ⁷⁰ and the β-flap of Escherichia coli RNA polymerase inhibits extension of nascent RNA during early elongation

, 2005
Bryce E. Nickels, Sean J Garrity, Vladimir Mekler, Leonid Minakhin, Konstantin Severinov, Richard H. Ebright, Ann Hochschild   +6 more
openalex   +1 more source

Repair of rDNA in Saccharomyces cerevisiae: RAD4-independent strand- specific nucleotide excision repair of RNA polymerase I transcribed genes [PDF]

, 1996
Richard A. Verhage
openalex   +1 more source

RNA polymerase I is essential for driving the formation of 3D genome in early embryonic development in mouse, but not in human. [PDF]

Genome Med
Hou C, Tian GG, Hu S, Chen B, Li X, Xu B, Cao Y, Le W, Hu R, Chen H, Zhang Y, Fang Q, Zhang M, Wang Z, Zhang Z, Zhang J, Wei Z, Yao G, Wang Y, Yin P, Guo Y, Tong G, Teng X, Sun Y, Cao Y, Wu J.   +25 more
europepmc   +1 more source

Rate of transcription elongation and sequence-specific pausing by RNA polymerase I directly influence rRNA processing. [PDF]

J Biol Chem, 2022
Huffines AK, Engel KL, French SL, Zhang Y, Viktorovskaya OV, Schneider DA.   +5 more
europepmc   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Requirements for RNA Polymerase II Carboxyl-terminal Domain for Activated Transcription of Human Retroviruses Human T-Cell Lymphotropic Virus I and HIV-1 [PDF]

, 1996
Rene F. Chun, Kuan‐Teh Jeang
openalex   +1 more source

Acetylation of microtubule-binding PinX1 orchestrates ribosome biogenesis to nutrient starvation via the RNA polymerase I preinitiation complex. [PDF]

J Biol Chem
Lu G, Yang L, Zhang Q, Zhang S, Xiong Y, Li T, Zhang Y, Liu M, Zhang Y, Wu J, Weng Q, Liu X, Ji J, Wang H, Luo J.   +14 more
europepmc   +1 more source

Integrative Approaches for DNA Sequence‐Controlled Functional Materials

Advanced Functional Materials, EarlyView.
DNA is emerging as a programmable building block for functional materials with applications in biomimicry, biochemical, and mechanical information processing. The integration of simulations, experiments, and machine learning is explored as a means to bridge DNA sequences with macroscopic material properties, highlighting current advances and providing ...
Aaron Gadzekpo, Ewa Anna Oprzeska‐Zingrebe, Mariana Kozlowska, Lennart Hilbert, Iliya D. Stoev   +4 more
wiley   +1 more source