Results 71 to 80 of about 807,500 (308)

Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity

Cell Reports, 2020
Summary: Health and survival in old age can be improved by changes in gene expression. RNA polymerase (Pol) I is the essential, conserved enzyme whose task is to generate the pre-ribosomal RNA (rRNA). We find that reducing the levels of Pol I activity is
Guillermo Martínez Corrales, Danny Filer, Katharina C. Wenz, Abbie Rogan, George Phillips, Mengjia Li, Yodit Feseha, Susan J. Broughton, Nazif Alic   +8 more
doaj  

LGP2 directly interacts with flavivirus NS5 RNA-dependent RNA polymerase and downregulates its pre-elongation activities.

PLoS Pathogens, 2023
LGP2 is a RIG-I-like receptor (RLR) known to bind and recognize the intermediate double-stranded RNA (dsRNA) during virus infection and to induce type-I interferon (IFN)-related antiviral innate immune responses.
Zhongyuan Tan, Jiqin Wu, Li Huang, Ting Wang, Zhenhua Zheng, Jianhui Zhang, Xianliang Ke, Yuan Zhang, Yan Liu, Hanzhong Wang, Jianping Tao, Peng Gong   +11 more
doaj   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Ccr4-not regulates RNA polymerase I transcription and couples nutrient signaling to the control of ribosomal RNA biogenesis. [PDF]

PLoS Genetics, 2015
Ribosomal RNA synthesis is controlled by nutrient signaling through the mechanistic target of rapamycin complex 1 (mTORC1) pathway. mTORC1 regulates ribosomal RNA expression by affecting RNA Polymerase I (Pol I)-dependent transcription of the ribosomal ...
R Nicholas Laribee, Amira Hosni-Ahmed, Jason J Workman, Hongfeng Chen   +3 more
doaj   +1 more source

Taxonomy of Phleboviruses, Emphasizing Those That Are Sandfly-Borne

Viruses, 2021
Sandfly-borne phleboviruses (phylum Negarnavaricota, realm Riboviria, kingdom Orthornavirae, genus Phlebovirus) comprise three genome segments of ribonucleic acid (RNA) and which encode an RNA-dependent RNA polymerase, which they use to transcribe the ...
Charles H. Calisher, Mattia Calzolari
doaj   +1 more source

RNA Polymerase from the Fungus Aspergillus nidulans [PDF]

European Journal of Biochemistry, 1979
The DNA‐dependent RNA polymerase I (or A) from the lower eukaryote Aspergillus nidulans has been purified on a large scale to apparent homogeneity by homogenizing the fungal hyphae in liquid nitrogen, extraction of the enzyme at high salt concentration, precipitation of RNA polymerase activity with polymin P (a polyethylene imine), elution of the RNA ...
Stunnenberg, H.G., Wennekes, L.M.J., van den Broek, H.W.J.   +2 more
openaire   +3 more sources

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

Molecular insight into RNA polymerase I promoter recognition and promoter melting

Nature Communications, 2019
RNA polymerase I (Pol I) catalyses the transcription of pre-ribosomal RNA and for transcription initiation Pol I assembles with core factor and Rrn3 on the rDNA core promoter.
Yashar Sadian, Florence Baudin, Lucas Tafur, Brice Murciano, Rene Wetzel, Felix Weis, Christoph W. Müller   +6 more
doaj   +1 more source

Structural basis of RNA polymerase I pre-initiation complex formation and promoter melting

Nature Communications, 2020
RNA polymerase I (Pol I) catalyses the transcription of ribosomal RNA precursors, and its transcription initiation mechanism differs from that of Pol II and Pol III.
Michael Pilsl, Christoph Engel
doaj   +1 more source

Residue profile in predivergence sequences as a guide to the origin of DNA replication [PDF]

arXiv, 1999
DNA dependent RNA polymerase core subunits abb' conserved residues at frequencies most closely matched with codons at stage 10.4-11.1 in code evolution. An excess of acidic residues (stage 2 additions) lowered this estimate, but not by more than 2.3 stages.
arxiv