Results 161 to 170 of about 821,958 (335)
AT7519, a Novel Small Molecule Multi-Cyclin Dependent Kinase Inhibitor, Induces Apoptosis in Multiple Myeloma VIA GSK3 beta [PDF]
, 2008 Dysregulated cell cycling is a universal hallmark of cancer and is often mediated by abnormal activation of cyclin-dependent kinases (CDKs) and their cyclin partners.
Anderson, Kc +16 more
core
RNA Polymerase II transcription elongation and Pol II CTD Ser2 phosphorylation [PDF]
, 2014 Elizabeth A. Bowman, William G. Kelly
openalex +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Isolation of TFIIIC102 in Arabidopsis thaliana to better understand transcription [PDF]
, 2004 only availableIn eukaryotes, transcription is carried out by three RNA polymerases. RNA polymerase I (Pol I) transcribes genes encoding the large rRNAs, RNA Pol II transcribes genes encoding proteins involved in mRNA processing, and RNA Pol III ...
Harrington, Lynne
core
Transcription-Independent Functions of an RNA Polymerase II Subunit, Rpb2, During Genome Rearrangement in the Ciliate, Oxytricha trifallax [PDF]
, 2014 Jaspreet S. Khurana +4 more
openalex +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
c-Myc induced changes in higher order rDNA structure accompany growth factor stimulation of quiescent cells [PDF]
, 2007 Human c-Myc is believed to be a high level coordinator of protein synthesis capacity and cell growth rate, capable of activating transcription by all three nuclear RNA Polymerases.
Anthony P. H. Wright +2 more
core +1 more source