Results 161 to 170 of about 946,604 (388)
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Global control of RNA polymerase II
Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsRNA polymerase II (Pol II) is the multi-protein complex responsible for transcribing all protein-coding messenger RNA (mRNA). Most research on gene regulation is focused on the mechanisms controlling which genes are transcribed when, or on the mechanics of transcription.
Gillis, A, Berry, S
openaire +3 more sources
Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
Studying the Interplay between RNA Polymerase II and Nucleosome Dynamics [PDF]
, 2018 In Saccharomyces cerevisiae, histone H2A.Z is coded by the HTZ1 gene. It is a highly conserved variant of histone H2A and has many reported roles in chromosome segregation and transcriptional regulation, among others. In yeast, this gene is not essential,
Gerges , Ereny G. +1 more
core
The nature of the interaction of nucleosomes with a eukaryotic RNA polymerase II [PDF]
, 1979 David M.J. Lilley +2 more
openalex +1 more source
FEBS Open Bio, EarlyView.Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran +3 more
wiley +1 more source
The pause-initiation limit restricts transcription activation in human cells.
, 2019 Eukaryotic gene transcription is often controlled at the level of RNA polymerase II (Pol II) pausing in the promoter-proximal region. Pausing Pol II limits the frequency of transcription initiation ('pause-initiation limit'), predicting that the pause ...
Cramer, P., Gressel, S., Schwalb, B.
core +1 more source
MicroRNA genes are transcribed by RNA polymerase II
EMBO Journal, 2004 Yoontae Lee +6 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel +3 more
wiley +1 more source