Results 271 to 280 of about 946,604 (388)

SSUP-72/PINN-1 coordinates RNA-polymerase II 3' pausing and developmental gene expression in C. elegans. [PDF]

Nat Commun
Stubbe FX, Ponsard P, Steiner FA, Hermand D.   +3 more
europepmc   +1 more source

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

Advanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang, Yousheng Wu, Xuanlin Su, Kaiwei Cai, Man Ke, Niu He, Huili Zhu, Zefeng Tan, Jielin Zhu, Wensheng He, Min Peng, Shiqing Zhang, Hongcheng Mai, Anding Xu, Dan Lu   +14 more
wiley   +1 more source

Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters. [PDF]

Nat Commun
Shah SZ, Perry TN, Graziadei A, Cecatiello V, Kaliyappan T, Misiaszek AD, Müller CW, Ramsay EP, Vannini A.   +8 more
europepmc   +1 more source

Isolation and Molecular Characterization of a cDNA Encoding the 23-kDa Subunit of Human RNA Polymerase II

, 1989
Uttam Pati, S M Weissman
openalex   +1 more source

Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut

Science, 2016
N. Proudfoot
semanticscholar   +1 more source

The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels

Advanced Science, EarlyView.
In breast cancer (BC), NUMB loss of function (LOF) is common and mainly driven by protein hyper‐degradation. The CRL7FBXW8 complex is the E3 ligase responsible for NUMB degradation. Inhibition of CRL7FBXW8 in NUMB‐LOF BC cells restores NUMB levels, and decreases the number of cancer stem cells and tumorigenic ability in vivo. Targeting CRL7FBXW8 offers
Simone Sabbioni, Maria Grazia Filippone, Letizia Amadori, Stefano Confalonieri, Roberta Bonfanti, Stefano Capoano, Ivan Nicola Colaluca, Stefano Freddi, Giovanni Bertalot, Giovanni Fagà, Elisa Zagarrí, Mario Varasi, Rosalind Helen Gunby, Ciro Mercurio, Salvatore Pece, Pier Paolo Di Fiore, Daniela Tosoni   +16 more
wiley   +1 more source

The transcription factor IID subunit Taf13 is dispensable for TATA binding protein promoter recruitment and RNA polymerase II transcription. [PDF]

iScience
Martianov I, Le Gras S, Davidson G, Davidson I.   +3 more
europepmc   +1 more source

Stereotyped Subclones Revealed by High‐Density Single‐Cell Lineage Tracing Support Robust Development

Advanced Science, EarlyView.
Based on a well‐established in vitro directed differentiation model and an integrated analysis of high‐density cell lineage trees (CLTs) and single‐cell transcriptomes, it is demonstrated that many subclones are formed by sub‐CLTs resembling each other in terms of both cell type compositions and topological structures.
Xiaoyu Zhang, Zizhang Li, Jingyu Chen, Wenjing Yang, Xingxing He, Peng Wu, Feng Chen, Ziwei Zhou, Chenze Ren, Yuyan Shan, Xiewen Wen, Vassily A. Lyubetsky, Leonid Yu. Rusin, Xiaoshu Chen, Jian‐Rong Yang   +14 more
wiley   +1 more source

Notch induces transcription by stimulating release of paused RNA polymerase II. [PDF]

Genes Dev
Rogers JM, Mimoso CA, Martin BJE, Martin AP, Aster JC, Adelman K, Blacklow SC.   +6 more
europepmc   +1 more source

Footprinting analysis of mammalian RNA polymerase II along its transcript: an alternative view of transcription elongation. [PDF]

, 1991
Gretchen A. Rice, C M Kane, Michael J. Chamberlin   +2 more
openalex   +1 more source