Results 71 to 80 of about 946,604 (388)
Life, 2022 RNAs not only offer valuable information regarding our bodies but also regulate cellular functions, allowing for their specific manipulations to be extensively explored for many different biological and clinical applications.
Hyesung Jo, Jiyun Beon, Seung Soo Oh
doaj +1 more source
Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis. [PDF]
, 2017 Most BRCA1-associated breast tumours are basal-like yet originate from luminal progenitors. BRCA1 is best known for its functions in double-strand break repair and resolution of DNA replication stress.
Angel Pujana, Miguel +29 more
core +2 more sources
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
FACT, a Factor that Facilitates Transcript Elongation through Nucleosomes [PDF]
, 1998 The requirements for transcriptional activation by RNA polymerase II were examined using chromatin templates assembled in vitro and a transcription system composed of the human general transcription factors and RNA polymerase II.
Chang, Chun-Hsiang +4 more
core +1 more source
Chromatin meets RNA polymerase II [PDF]
Genome Biology, 2007 A report on the Cold Spring Harbor Laboratory meeting 'Mechanisms of eukaryotic transcription', Cold Spring Harbor, USA, 2 August-2 September 2007.
B. Franklin Pugh, Bryan J. Venters
openaire +2 more sources
FEBS Letters, EarlyView.To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche +2 more
wiley +1 more source
Repression of RNA polymerase II transcription by a Drosophila oligopeptide. [PDF]
PLoS ONE, 2008 BACKGROUND: Germline progenitors resist signals that promote differentiation into somatic cells. This occurs through the transient repression in primordial germ cells of RNA polymerase II, specifically by disrupting Ser2 phosphorylation on its C-terminal
Gyula Timinszky +2 more
doaj +1 more source
, 2015 Polymerases are protein enzymes that move along nucleic acid chains and catalyze template-based polymerization reactions during gene transcription and replication.
Yu, Jin
core +1 more source
Transient pausing by RNA polymerase II [PDF]
Proceedings of the National Academy of Sciences, 2018 RNA polymerase II (Pol II) elongation control is utilized during transcription of most metazoan genes (1). Polymerases that successfully initiate must first break contacts with initiation factors and then interact with elongation factors including the DRB sensitivity-inducing factor (DSIF) and the negative elongation factor (NELF).
openaire +2 more sources
Structure of a transcribing RNA polymerase II–U1 snRNP complex
Science, 2020 A tight couple makes messenger RNAs Gene expression in eukaryotes first requires transcription of DNA to an RNA copy and then splicing to form the final, processed messenger RNA (mRNA). Zhang et al.
Suyang Zhang +5 more
semanticscholar +1 more source