Results 91 to 100 of about 2,192,206 (343)

Helical defects in microRNA influence protein binding by TAR RNA binding protein.

PLoS ONE, 2015
BackgroundMicroRNAs (miRNAs) are critical post-transcriptional regulators of gene expression. Their precursors have a globally A-form helical geometry, which prevents most proteins from identifying their nucleotide sequence.
Roderico Acevedo, Nichole Orench-Rivera, Kaycee A Quarles, Scott A Showalter   +3 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

RNA-Catalyzed Polymerization of Deoxyribose, Threose, and Arabinose Nucleic Acids [PDF]

, 2019
An RNA-dependent RNA polymerase ribozyme that was highly optimized through in vitro evolution for the ability to copy a broad range of template sequences exhibits promiscuity toward other nucleic acids and nucleic acid analogues, including DNA, threose ...
Gerald F. Joyce (323692), David P. Horning (6663110), Chaput, John C, David P. Horning, Bala, Saikat, Gerald F. Joyce, John C. Chaput (29064), Saikat Bala, Saikat Bala (2396920), John C. Chaput, Horning, David P, Joyce, Gerald F   +11 more
core   +1 more source

PIWI Slicing and RNA Elements in Precursors Instruct Directional Primary piRNA Biogenesis

Cell Reports, 2015
PIWI proteins and PIWI-interacting RNAs (piRNAs) mediate repression of transposons in the animal gonads. Primary processing converts long single-stranded RNAs into ∼30-nt piRNAs, but their entry into the biogenesis pathway is unknown.
David Homolka, Radha Raman Pandey, Coline Goriaux, Emilie Brasset, Chantal Vaury, Ravi Sachidanandam, Marie-Odile Fauvarque, Ramesh S. Pillai   +7 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Molecular and developmental analysis of non-coding RNA metabolism in" C. elegans" : the exoribonuclease XRN2 and the RNA- binding proteins SART-3 and USIP-1 [PDF]

, 2014
About three quarters of a eukaryotic genome are transcribed into RNA. However, only
Rüegger, Stefan
core   +1 more source

Role of CXCL10 released from osteocytes in response to TNF-α stimulation on osteoclasts

Scientific Reports
Tumor necrosis factor-alpha (TNF-α) is a significant cytokine that regulates bone resorption under inflammatory conditions. However, its mechanism of action in osteocytes remains unclear.
Mariko Miura, Hideki Kitaura, Fumitoshi Ohori, Kohei Narita, Jiayi Ren, Takahiro Noguchi, Aseel Marahleh, Jinghan Ma, Angyi Lin, Ziqiu Fan, Itaru Mizoguchi   +10 more
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

A Database for TSSs of Human MicroRNAs

, 2012
MicroRNAs (miRNAs) are small endogeneous non-coding RNAs of about 22nt length. These short RNAs regulate the expression of mRNAs by hybridizing with their 3'-UTRs or by translational repression.
Sanghamitra Bandyopadhyay, Malay Bhattacharyya, Malay Bhattacharyya, Sanghamitra B   +3 more
core   +1 more source

Profiling and characterization of a longissimus dorsi muscle microRNA dataset from an F2 Duroc × Pietrain pig resource population

Genomics Data, 2017
To elucidate the effects of microRNA (miRNA) regulation in skeletal muscle of adult pigs, miRNA expression profiling was performed with RNA extracted from longissimus dorsi (LD) muscle samples from 174 F2 pigs (~5.5 months of age) from a Duroc × Pietrain
Kaitlyn R. Daza, Juan P. Steibel, Deborah Velez-Irizarry, Nancy E. Raney, Ronald O. Bates, Catherine W. Ernst   +5 more
doaj   +1 more source