Results 91 to 100 of about 320,389 (303)

Role of CXCL10 released from osteocytes in response to TNF-α stimulation on osteoclasts

Scientific Reports
Tumor necrosis factor-alpha (TNF-α) is a significant cytokine that regulates bone resorption under inflammatory conditions. However, its mechanism of action in osteocytes remains unclear.
Mariko Miura, Hideki Kitaura, Fumitoshi Ohori, Kohei Narita, Jiayi Ren, Takahiro Noguchi, Aseel Marahleh, Jinghan Ma, Angyi Lin, Ziqiu Fan, Itaru Mizoguchi   +10 more
doaj   +1 more source

Profiling and characterization of a longissimus dorsi muscle microRNA dataset from an F2 Duroc × Pietrain pig resource population

Genomics Data, 2017
To elucidate the effects of microRNA (miRNA) regulation in skeletal muscle of adult pigs, miRNA expression profiling was performed with RNA extracted from longissimus dorsi (LD) muscle samples from 174 F2 pigs (~5.5 months of age) from a Duroc × Pietrain
Kaitlyn R. Daza, Juan P. Steibel, Deborah Velez-Irizarry, Nancy E. Raney, Ronald O. Bates, Catherine W. Ernst   +5 more
doaj   +1 more source

Suppression of ILC2 differentiation from committed T cell precursors by E protein transcription factors [PDF]

, 2019
Current models propose that group 2 innate lymphoid cells (ILC2s) are generated in the bone marrow. Here, we demonstrate that subsets of these cells can differentiate from multipotent progenitors and committed T cell precursors in the thymus, both in ...
Adrianto, Indra, Alberola-Ila, Jose, Bajana, Sandra, Colonna, Marco, Georgescu, Constantin, Peng, Vincent, Qian, Liangyue, Sun, Xiao-Hong, Wang, Hong-Cheng, Wren, Jonathan D   +9 more
core   +1 more source

Transport of Proteins into Mitochondria [PDF]

, 1980
The mitochondrial ADP/ATP carrier is an integral transmembrane protein of the inner membrane. It is synthesized on cytoplasmic ribosomes. Kinetic data suggested that this protein is transferred into mitochondria in a posttranslational manner.
Allen E. H., Brdiezka D., Chang C. N., Chang C. N., Conboy J. G., Cote C., Date T., Dobberstein B., Flavell R. B., Habermann E., Hackenberg H., Hallermayer G., Harmey M. A., Highfield P. E., Ito K., Klingenberg M., Knoppel E., Korb H., Kreil G., Laemmli U. K., Maccechini M. L., Maccechini M.-L., Mandel G., Marra E., Michel R., Milstein C., Mori M., Nelson N., Pelham H. R. B., Poyton R. O., Poyton R. O., Raymond Y., Schatz G., Sessa G., Shore G. S., Strauss A. W., Vignais P. V., Wickner W., Wickner W., Williams J. C., Zimmermann R., Zimmermann R.   +41 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Human miRNA precursors with box H/ACA snoRNA features.

PLoS Computational Biology, 2009
MicroRNAs (miRNAs) and small nucleolar RNAs (snoRNAs) are two classes of small non-coding regulatory RNAs, which have been much investigated in recent years.
Michelle S Scott, Fabio Avolio, Motoharu Ono, Angus I Lamond, Geoffrey J Barton   +4 more
doaj   +1 more source

On the Reproducibility of TCGA Ovarian Cancer MicroRNA Profiles [PDF]

, 2013
Dysregulated microRNA (miRNA) expression is a well-established feature of human cancer. However, the role of specific miRNAs in determining cancer outcomes remains unclear.
Allen, Genevera, Anderson, Matthew L., Liu, Zhandong, Mach, Claire M., Wan, Ying-Wooi   +4 more
core   +3 more sources

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

The Conserved RNA Exonuclease Rexo5 Is Required for 3′ End Maturation of 28S rRNA, 5S rRNA, and snoRNAs

Cell Reports, 2017
Non-coding RNA biogenesis in higher eukaryotes has not been fully characterized. Here, we studied the Drosophila melanogaster Rexo5 (CG8368) protein, a metazoan-specific member of the DEDDh 3′-5′ single-stranded RNA exonucleases, by genetic, biochemical,
Stefanie Gerstberger, Cindy Meyer, Sigi Benjamin-Hong, Joe Rodriguez, Daniel Briskin, Claudia Bognanni, Kimberly Bogardus, Hermann Steller, Thomas Tuschl   +8 more
doaj   +1 more source