Results 291 to 300 of about 2,192,206 (343)

Speculation on the RNA Precursor Problem

Journal of Theoretical Biology, 1997
While no convincing prebiotic synthesis of RNA building blocks has been demonstrated, at least two synthetic analogues of nucleic acids have been described whose properties are remarkably similar to those of RNA. The RNA backbone is thus not the only possible solution to the problem of replicating the information stored in a sequence of purines and ...
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Splicing of messenger RNA precursors

BioEssays, 1985
AbstractThe splicing of pre‐mRNAs in vitro is accomplished by formation of RNA intermediates in a lariat form. Lariat RNAs have been recently identified in vivo supporting the validity of the proposed pathway for processing pre‐mRNAs in vitro.We have recently reported20 a partial purification scheme for a pre‐mRNA splicing activity. Purification of the
Satish Patwardhan, Gustavo Kaltwasser, Peter R. Dimaria, Carlos J. Goldenberg   +3 more
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A precursor of globin messenger RNA

Journal of Molecular Biology, 1976
Abstract The size of pulse-labeled globin messenger RNA nucleotide sequences was investigated, to determine whether newly transcribed globin mRNA molecules are larger than steady-state globin mRNA. Molecular hybridization techniques were used to compare directly the sedimentation of steady-state (unlabeled) and pulse-labeled (radioactive) globin mRNA
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Enzymatic N-riboside scission in RNA and RNA precursors

Current Opinion in Chemical Biology, 1997
N-ribohydrolases and transferases act on nucleosides, nucleotides and oligonucleotides to effect base removal. Advances in mechanistic and structural analysis have established that enzymes of N-riboside scission act by combinations of leaving-group and ribosyl activation.
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A precursor for a small stable RNA (10Sa RNA) ofEscherichia coli

Molecular and General Genetics MGG, 1989
Strains carrying plasmids that code for 10Sa RNA synthesize a larger molecule when the RNA processing enzyme RNase E is inactivated. The T1 fingerprint of 10Sa RNA and the larger molecule is very similar, but the latter contains additional oligonucleotides. We show that the larger RNA is converted to the smaller, mature RNA.
M N, Subbarao, D, Apirion
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An axial binding site in the Tetrahymena precursor RNA

Journal of Molecular Biology, 1991
Previous studies allow the construction of three distinct models of the binding of G and arginine within the active site of the Tetrahymena self-splicing preribosomal precursor RNA. These models (base triple, axial I and axial II) are now distinguished by measurements on the specificity of RNAs with nucleotide substitutions at positions spanning the ...
M, Yarus, M, Illangesekare, E, Christian
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RNA Required for Import of Precursor Proteins into Mitochondria

Science, 1984
A cytoplasmic RNA moiety is necessary for posttranslational uptake of nuclear-encoded mammalian proteins destined for the mitochondrial matrix. Post-translational addition of ribonuclease to a reticulocyte lysate-programmed cell-free translation mixture inhibited subsequent import of six different mitochondrial matrix enzyme precursors into rat liver ...
F A, Firgaira, J P, Hendrick, F, Kalousek, J P, Kraus, L E, Rosenberg   +4 more
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Asymmetric maturation of a dimeric transfer RNA precursor

Journal of Molecular Biology, 1980
Abstract Six of the eight transfer RNAs coded by bacteriophage T4 are synthesized via three dimeric precursor molecules. The sequences of two of these have been determined. Both of these precursors give rise to equimolar amounts of the cognate tRNA molecules in vivo .
C, Guthrie, C A, Scholla
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Precursors of alpha and beta globin messenger RNAs

Journal of Molecular Biology, 1978
Abstract Several structural properties of the pulse-labeled globin messenger RNA precursor molecules that sediment faster than steady-state (10 S) globin mRNA (Curtis & Weissmann, 1976; Ross, 1976; Kwan et al., 1977; Bastos & Aviv, 1977) are investigated.
J, Ross, D A, Knecht
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Precursor 16S RNA in Active 30S Ribosomes

Nature, 1974
BIOGENESIS of bacterial ribosomes proceeds through the formation of precursor particles1–4, consisting of an incomplete set of ribosomal protein5 and of RNA molecules that are longer and less methylated than mature RNA4,6,7. RNA maturation is commonly considered to be a part of the ribosome maturation process.
G, Mangiarotti, E, Turco, A, Ponzetto, F, Altruda   +3 more
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