Results 241 to 250 of about 376,369 (323)

RVINN: a flexible modeling for inferring dynamic transcriptional and post-transcriptional regulation using physics-informed neural networks. [PDF]

Bioinformatics
Muto O, Guo Z, Yamaguchi R.
europepmc   +1 more source

Self-inactivating retroviral vectors with improved RNA processing

Gene Therapy, 2004
J. Kraunus, J. Kraunus, D. H. S. Schaumann, J. Meyer, U. Modlich, B. Fehse, Gunda Brandenburg, D. Laer, Hannes Klump, A. Schambach, J. Bohne, C. Baum, C. Baum   +12 more
semanticscholar   +1 more source

3D‐Printed Scaffolds Promote Enhanced Spinal Organoid Formation for Use in Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
3D‐printed organoid scaffolds with microscale channels are developed to enhance spinal cord injury recovery by guiding region‐specific spinal neural progenitor cells. These scaffolds promote axonal growth, cell maturation, and neuronal network formation.
Guebum Han, Nicolas S. Lavoie, Nandadevi Patil, Olivia G. Korenfeld, Hyunjun Kim, Manuel Esguerra, Daeha Joung, Michael C. McAlpine, Ann M. Parr   +8 more
wiley   +1 more source

Regulatory orchestration of FK506 biosynthesis in <i>Streptomyces tsukubaensis</i> NRRL 18488 revealed through systematic analysis. [PDF]

iScience
Lee N, Kim W, Kim JH, Lee Y, Hwang S, Kim G, Kim H, Dan Q, Schmidt M, Yoon YJ, Cho S, Palsson B, Keasling JD, Cho BK.   +13 more
europepmc   +1 more source

Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in microfluidic technologies for modeling human aging and age‐related diseases. It explores how organ‐on‐chip platforms improve physiological relevance, enable rejuvenation strategies, facilitate drug screening, detect senescent cells, and identify biomarkers.
Limor Zwi‐Dantsis, Vignesh Jayarajan, George M. Church, Roger D. Kamm, João Pedro de Magalhães, Emad Moeendarbary   +5 more
wiley   +1 more source

Longitudinal transcriptomic and epigenetic analysis of the blood in two astronauts. [PDF]

Sci Rep
Ao X, Parisien M, Cata JP, Montagna F, Vigouroux M, Oliveira Fernandes de Araujo L, Karaky M, Ingelmo P, Diatchenko L.   +8 more
europepmc   +1 more source

Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response

Advanced Healthcare Materials, EarlyView.
In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim, Jin Woong Lee, Piper A. Rawding, Mari Iida, Carter Kim, Kourtney L. Kostecki, Michael J. Poellmann, Bridget Crossman, Ashley S. Liu, YoungSoo Kim, Deric L. Wheeler, Seungpyo Hong   +11 more
wiley   +1 more source

Epitranscriptomic Control of Drought Tolerance in Rice: The Role of RNA Methylation. [PDF]

Plants (Basel)
Fan X, Zhang Y, Gu P, Naz M.
europepmc   +1 more source

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Articoli Fire(RNAi) / Zamore(siRNA) / Berstein(DICER) [PDF]

, 2012
Danielli, Alberto
core