Results 51 to 60 of about 2,532,976 (299)
陆军军医大学学报Objective To analyze the composition characteristics and biological functions of tumor cell subpopulations in glioblastoma (GBM) through multi-transcriptomics sequencing technology, and explore the hypoxia characteristics and spatial localization ...
CHEN Tao, YANG Fan, WANG Shuai
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DNApi: A De Novo Adapter Prediction Algorithm for Small RNA Sequencing Data. [PDF]
PLoS ONE, 2016 With the rapid accumulation of publicly available small RNA sequencing datasets, third-party meta-analysis across many datasets is becoming increasingly powerful.
Junko Tsuji, Zhiping Weng
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FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Protocol for identifying differentially expressed genes using the RumBall RNA-seq analysis platform
STAR ProtocolsSummary: Here, we present a protocol for the identification of differentially expressed genes through RNA sequencing analysis. Starting with FASTQ files from public datasets, this protocol leverages RumBall within a self-contained Docker system.
Luis Augusto Eijy Nagai +2 more
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Metagenomic Analysis of Marigold: Mixed Infection Including Two New Viruses
Viruses, 2021 Marigold plants with symptoms of mosaic, crinkle, leaf curl and necrosis were observed and small RNA and ribo-depleted total RNA deep sequencing were conducted to identify the associated viruses.
Hang Yin +7 more
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The hitchhikers’ guide to RNA sequencing and functional analysis
Briefings in Bioinformatics, 2023 Abstract DNA and RNA sequencing technologies have revolutionized biology and biomedical sciences, sequencing full genomes and transcriptomes at very high speeds and reasonably low costs. RNA sequencing (RNA-Seq) enables transcript identification and quantification, but once sequencing has concluded researchers can be easily overwhelmed ...
Jiung-Wen Chen +4 more
openaire +2 more sources
Nature Protocols, 2013 De novo assembly of RNA-seq data enables researchers to study transcriptomes without the need for a genome sequence; this approach can be usefully applied, for instance, in research on 'non-model organisms' of ecological and evolutionary importance ...
B. Haas +22 more
semanticscholar +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Frontiers in Neuroscience, 2020 Potential pathogenic factors, other than well-known APP, APOE4, and PSEN, can be further identified from transcriptomics studies of differentially expressed genes (DEGs) that are specific for Alzheimer’s disease (AD), but findings are often inconsistent ...
Sze Chung Yuen +3 more
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