Results 11 to 20 of about 1,474,432 (298)
RNA Sequencing in Schizophrenia [PDF]
Bioinformatics and Biology Insights, 2015 Schizophrenia (SCZ) is a serious psychiatric disorder that affects 1% of general population and places a heavy burden worldwide. The underlying genetic mechanism of SCZ remains unknown, but studies indicate that the disease is associated with a global ...
Xin Li, Shaolei Teng
doaj +4 more sources
Immunoprecipitation and Sequencing of Acetylated RNA [PDF]
Bio-Protocol, 2019 Generation of the epitranscriptome through chemical modifications of protein-coding messenger RNAs (mRNAs) has emerged as a new mechanism of post-transcriptional gene regulation.
Daniel Arango +2 more
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RNA Sequencing and Analysis [PDF]
Cold Spring Harbor Protocols, 2015 RNA sequencing (RNA-Seq) uses the capabilities of high-throughput sequencing methods to provide insight into the transcriptome of a cell. Compared to previous Sanger sequencing- and microarray-based methods, RNA-Seq provides far higher coverage and greater resolution of the dynamic nature of the transcriptome.
Kimberly R, Kukurba +1 more
openaire +2 more sources
Advances in application of single-cell RNA sequencing in cardiovascular research
Frontiers in Cardiovascular Medicine, 2022 Single-cell RNA sequencing (scRNA-seq) provides high-resolution information on transcriptomic changes at the single-cell level, which is of great significance for distinguishing cell subtypes, identifying stem cell differentiation processes, and ...
Yue Hu +10 more
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Cell Reports, 2020 Summary: Dissecting the in vivo host-pathogen interplay is crucial to understanding the molecular mechanisms governing control or progression of intracellular infections.
Davide Pisu +3 more
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RNA modifications detection by comparative Nanopore direct RNA sequencing
Nature Communications, 2021 Nanopore direct RNA Sequencing data contain information about the presence of RNA modifications, but their detection poses substantial challenges. Here the authors introduce Nanocompore, a new methodology for modification detection from Nanopore data.
Adrien Leger +18 more
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Molecular Therapy: Nucleic Acids, 2021 We present MultiEditR (Multiple Edit Deconvolution by Inference of Traces in R), the first algorithm specifically designed to detect and quantify RNA editing from Sanger sequencing (z.umn.edu/multieditr).
Mitchell G. Kluesner +8 more
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Epidermal Growth Factor Receptor Mutation and Anaplastic Lymphoma Kinase Gene Fusion: Detection in Malignant Pleural Effusion by RNA or PNA Analysis. [PDF]
PLoS ONE, 2016 Analyzing EGFR mutations and detecting ALK gene fusion are indispensable when planning to treat pulmonary adenocarcinoma. Malignant pleural effusion (MPE) is a devastating complication of lung cancer and sometimes the only source for mutation analysis ...
Yi-Lin Chen +10 more
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Single genome sequencing of near full-length HIV-1 RNA using a limiting dilution approach [PDF]
, 2019 Sequencing very long stretches of the HIV-1 genome can advance studies on virus evolution and in vivo recombination but remains technically challenging.
Demecheleer, Els +7 more
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Detecting RNA modification using direct RNA sequencing: A systematic review
Computational and Structural Biotechnology Journal, 2022 Post-transcriptional RNA modifications are involved in a range of important cellular processes, including the regulation of gene expression and fine-tuning of the functions of RNA molecules.
Xichen Zhao +4 more
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