Results 1 to 10 of about 154,659 (331)

RNA-Targeting Splicing Modifiers: Drug Development and Screening Assays [PDF]

Molecules, 2021
RNA splicing is an essential step in producing mature messenger RNA (mRNA) and other RNA species. Harnessing RNA splicing modifiers as a new pharmacological modality is promising for the treatment of diseases caused by aberrant splicing.
Zhichao Tang, Junxing Zhao, Zach J. Pearson, Zarko V. Boskovic, Jingxin Wang   +4 more
doaj   +3 more sources

Methods to study splicing from high-throughput RNA Sequencing data [PDF]

Methods Mol Biol. 2014;1126:357-97, 2013
The development of novel high-throughput sequencing (HTS) methods for RNA (RNA-Seq) has provided a very powerful mean to study splicing under multiple conditions at unprecedented depth. However, the complexity of the information to be analyzed has turned this into a challenging task.
A Ameur, A Bhasi, A Dobin, A Mortazavi, A Oshlack, A Roberts, A Roberts, AM Mezlini, AN Brooks, B Jackson, B Kakaradov, B Langmead, B Li, B Li, BJ Haas, BJ Haas, C Trapnell, C Trapnell, C Trapnell, D Hiller, D Singh, DL Wood, DW Bryant, E Eyras, E Lee, E Turro, ET Wang, F Birzele, F Bona De, F Denoeud, F Tang, G Robertson, G Xu, GA Sacomoto, GR Grant, GS Slater, H Bao, H Jiang, H Jiang, H Kim, H Richard, J Behr, J Du, J Feng, J Hu, J Lovén, J Martin, J Salzman, J Seok, J Seok, J Wu, J Wu, JE Allen, JJ Li, JP Venables, K Schneeberger, K Wang, KD Hansen, KF Au, KL Howe, KM Borgwardt, L Chen, L Chen, L Wang, L Wang, LY Chen, M Aschoff, M Fiume, M Garber, M Griffith, M Guttman, M Stanke, M Stanke, M Sultan, MC Ryan, MF Rogers, MG Grabherr, MH Schulz, MT Dimon, N Cloonan, N Cloonan, N Deng, N Leng, N Nicolae, N Philippe, N Vijay, NA Fonseca, O Stegle, P Drewe, P Glaus, PL Martelli, PP Labaj, Q Liu, Q Liu, Q Pan, QY Zhao, R Bohnert, R Guigó, R Li, S Anders, S Djebali, S Filichkin, S Heber, S Huang, S Lee, S Mangul, S Marco-Sola, S Shen, S Sonnenburg, S Srivastava, S Tang, S Zheng, SB Montgomery, SH Nagaraj, SK Lou, T Bonfert, TA Clark, TD Wu, TD Wu, W Li, W Li, W Wang, WJ Kent, Y Hu, Y Katz, Y Li, Y Liao, Y Surget-Groba, Y Xing, Y Xing, Y Zhang, Z Xia   +131 more
arxiv   +3 more sources

Linking splicing to Pol II transcription stabilizes pre-mRNAs and influences splicing patterns. [PDF]

PLoS Biology, 2006
RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in vitro transcription/splicing assay, we demonstrate that an association of RNA polymerase ...
Martin J Hicks, Chin-Rang Yang, Matthew V Kotlajich, Klemens J Hertel   +3 more
doaj   +5 more sources

Dysregulation of RNA Splicing in Tauopathies [PDF]

Cell Reports, 2019
Summary: Pathological aggregation of RNA binding proteins (RBPs) is associated with dysregulation of RNA splicing in PS19 P301S tau transgenic mice and in Alzheimer’s disease brain tissues. The dysregulated splicing particularly affects genes involved in
Daniel J. Apicco, Cheng Zhang, Brandon Maziuk, Lulu Jiang, Heather I. Ballance, Samantha Boudeau, Choong Ung, Hu Li, Benjamin Wolozin   +8 more
doaj   +3 more sources

Quantifying alternative splicing from paired-end RNA-sequencing data [PDF]

Annals of Applied Statistics 2014, Vol. 8, No. 1, 309-330, 2014
RNA-sequencing has revolutionized biomedical research and, in particular, our ability to study gene alternative splicing. The problem has important implications for human health, as alternative splicing may be involved in malfunctions at the cellular level and multiple diseases.
Attolini, Camille Stephan-Otto, Kroiss, Manuel, Rossell, David, Stöcker, Almond   +3 more
arxiv   +3 more sources

Alternative Splicing in Myeloid Malignancies [PDF]

Biomedicines, 2021
Alternative RNA splicing (AS) is an essential physiologic function that diversifies the human proteome. AS also has a crucial role during cellular development.
Carmelo Gurnari, Simona Pagliuca, Valeria Visconte   +2 more
doaj   +3 more sources

Murine leukemia virus RNA dimerization is coupled to transcription and splicing processes [PDF]

Retrovirology, 2010
Most of the cell biological aspects of retroviral genome dimerization remain unknown. Murine leukemia virus (MLV) constitutes a useful model to study when and where dimerization occurs within the cell.
Maurel Stéphan, Mougel Marylène
doaj   +5 more sources

Aberrant splicing in human cancer: An RNA structural code point of view

Frontiers in Pharmacology, 2023
Alternative splicing represents an essential process that occurs widely in eukaryotes. In humans, most genes undergo alternative splicing to ensure transcriptome and proteome diversity reflecting their functional complexity.
Maria Apostolidi, Vassiliki Stamatopoulou   +1 more
doaj   +1 more source

Altered splicing of ATG16‐L1 mediates acquired resistance to tyrosine kinase inhibitors of EGFR by blocking autophagy in non‐small cell lung cancer

Molecular Oncology, 2022
Despite the initial efficacy of using tyrosine kinase inhibitors of epidermal growth factor receptors (EGFR‐TKIs) for treating patients with non‐small cell lung cancer (NSCLC), resistance inevitably develops.
Anne‐Sophie Hatat, Clara Benoit‐Pilven, Amélie Pucciarelli, Florence deFraipont, Lucie Lamothe, Pascal Perron, Amandine Rey, Matteo Giaj Levra, Anne‐Claire Toffart, Didier Auboeuf, Beatrice Eymin, Sylvie Gazzeri   +11 more
doaj   +1 more source

Regulation of RNA Splicing: Aberrant Splicing Regulation and Therapeutic Targets in Cancer

Cells, 2021
RNA splicing is a critical step in the maturation of precursor mRNA (pre-mRNA) by removing introns and exons. The combination of inclusion and exclusion of introns and exons in pre-mRNA can generate vast diversity in mature mRNA from a limited number of ...
Koji Kitamura, Keisuke Nimura
doaj   +1 more source