Regulation of RNA Splicing: Aberrant Splicing Regulation and Therapeutic Targets in Cancer
Cells, 2021 RNA splicing is a critical step in the maturation of precursor mRNA (pre-mRNA) by removing introns and exons. The combination of inclusion and exclusion of introns and exons in pre-mRNA can generate vast diversity in mature mRNA from a limited number of ...
Koji Kitamura, Keisuke Nimura
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Methods to study splicing from high-throughput RNA Sequencing data [PDF]
Methods Mol Biol. 2014;1126:357-97, 2013 The development of novel high-throughput sequencing (HTS) methods for RNA (RNA-Seq) has provided a very powerful mean to study splicing under multiple conditions at unprecedented depth. However, the complexity of the information to be analyzed has turned this into a challenging task.
A Ameur +131 more
arxiv +3 more sources
The potential impact of RNA splicing abnormalities on immune regulation in endometrial cancer [PDF]
Cell Death and DiseaseRNA splicing controls the post-transcriptional level of gene expression, allowing for the synthesis of many transcripts with various configurations and roles.
Minyue Cao +7 more
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Quantifying alternative splicing from paired-end RNA-sequencing data [PDF]
Annals of Applied Statistics 2014, Vol. 8, No. 1, 309-330, 2014 RNA-sequencing has revolutionized biomedical research and, in particular, our ability to study gene alternative splicing. The problem has important implications for human health, as alternative splicing may be involved in malfunctions at the cellular level and multiple diseases.
Attolini, Camille Stephan-Otto +3 more
arxiv +3 more sources
Dysregulation of RNA Splicing in Tauopathies [PDF]
Cell Reports, 2019 Summary: Pathological aggregation of RNA binding proteins (RBPs) is associated with dysregulation of RNA splicing in PS19 P301S tau transgenic mice and in Alzheimer’s disease brain tissues. The dysregulated splicing particularly affects genes involved in
Daniel J. Apicco +8 more
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Alternative RNA Splicing in Fatty Liver Disease
Frontiers in Endocrinology, 2021 Alternative RNA splicing is a process by which introns are removed and exons are assembled to construct different RNA transcript isoforms from a single pre-mRNA.
Panyisha Wu +4 more
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Aberrant RNA Splicing in Cancer [PDF]
Annual Review of Cancer Biology, 2019 RNA splicing, the enzymatic process of removing segments of premature RNA to produce mature RNA, is a key mediator of proteome diversity and regulator of gene expression. Increased systematic sequencing of the genome and transcriptome of cancers has identified a variety of means by which RNA splicing is altered in cancer relative to normal cells ...
Luisa F. Escobar-Hoyos +4 more
openaire +4 more sources
Lamin B1 regulates RNA splicing factor expression by modulating the spatial positioning and chromatin interactions of the ETS1 gene locus [PDF]
Animal Cells and SystemsLamin B1, a crucial component of the nuclear lamina, plays a pivotal role in chromatin organization and transcriptional regulation in eukaryotic cells. While recent studies have highlighted the connection between Lamin B1 and RNA splicing regulation, the
Geun-Seup Shin +9 more
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A polynomial delay algorithm for the enumeration of bubbles with length constraints in directed graphs and its application to the detection of alternative splicing in RNA-seq data [PDF]
arXiv, 2013 We present a new algorithm for enumerating bubbles with length constraints in directed graphs. This problem arises in transcriptomics, where the question is to identify all alternative splicing events present in a sample of mRNAs sequenced by RNA-seq.
Lacroix, Vincent +2 more
arxiv +3 more sources
RNA splicing factors as oncoproteins and tumour suppressors
Nature Reviews Cancer, 2016 Heidi Dvinge +2 more
exaly +2 more sources