Results 1 to 10 of about 1,384,640 (333)

RNA-Targeting Splicing Modifiers: Drug Development and Screening Assays [PDF]

Molecules, 2021
RNA splicing is an essential step in producing mature messenger RNA (mRNA) and other RNA species. Harnessing RNA splicing modifiers as a new pharmacological modality is promising for the treatment of diseases caused by aberrant splicing.
Zhichao Tang, Junxing Zhao, Zach J. Pearson, Zarko V. Boskovic, Jingxin Wang   +4 more
doaj   +2 more sources

Regulation of RNA Splicing: Aberrant Splicing Regulation and Therapeutic Targets in Cancer

Cells, 2021
RNA splicing is a critical step in the maturation of precursor mRNA (pre-mRNA) by removing introns and exons. The combination of inclusion and exclusion of introns and exons in pre-mRNA can generate vast diversity in mature mRNA from a limited number of ...
Koji Kitamura, Keisuke Nimura
doaj   +2 more sources

TET dioxygenases localize at splicing speckles and promote RNA splicing [PDF]

Nucleus
The dynamic regulation of RNA metabolism plays a crucial part in cellular function, with emerging evidence suggesting an important role for RNA modifications in this process.
Florian D. Hastert, Jasmin Weber, Christina Bauer, Andreas Zhadan, Deepanshu N. D. Singh, Thomas C. Dix, Roland Arnold, Sergey Bessonov, Matthias Soller, Heinrich Leonhardt, M. Cristina Cardoso, Maria Arroyo   +11 more
doaj   +2 more sources

Alternative RNA Splicing in Fatty Liver Disease

Frontiers in Endocrinology, 2021
Alternative RNA splicing is a process by which introns are removed and exons are assembled to construct different RNA transcript isoforms from a single pre-mRNA.
Panyisha Wu, Moya Zhang, Nicholas J. G. Webster, Nicholas J. G. Webster, Nicholas J. G. Webster   +4 more
doaj   +2 more sources

Prenatal exposure to bisphenol A disrupts RNA splicing in the prefrontal cortex and promotes behaviors related to autism in offspring [PDF]

Scientific Reports
Prenatal exposure to bisphenol A (BPA), a common endocrine disruptor, has been increasingly implicated in neurodevelopmental disorders, including autism spectrum disorder.
Pawinee Panjabud, Songphon Kanlayaprasit, Surangrat Thongkorn, Kwanjira Songsritaya, Pattanachat Lertpeerapan, Kasidit Kasitipradit, Thanawin Jantheang, Suthathip Sarobol, Thanit Saeliw, Valerie W. Hu, Takeshi Imai, Tewarit Sarachana   +11 more
doaj   +2 more sources

Long-read RNA-seq demarcates cis- and trans-directed alternative RNA splicing [PDF]

Nature Communications
Genetic regulation of alternative splicing constitutes an important link between genetic variation and disease. Nonetheless, RNA splicing is regulated by both cis-acting elements and trans-acting splicing factors.
Giovanni Quinones-Valdez, Kofi Amoah, Xinshu Xiao   +2 more
doaj   +2 more sources

The potential impact of RNA splicing abnormalities on immune regulation in endometrial cancer [PDF]

Cell Death and Disease
RNA splicing controls the post-transcriptional level of gene expression, allowing for the synthesis of many transcripts with various configurations and roles.
Minyue Cao, Jiayu Yan, Yan Ding, Yiqin Zhang, Yihan Sun, Genyi Jiang, Yanli Zhang, Bilan Li   +7 more
doaj   +2 more sources

Aberrant splicing in human cancer: An RNA structural code point of view

Frontiers in Pharmacology, 2023
Alternative splicing represents an essential process that occurs widely in eukaryotes. In humans, most genes undergo alternative splicing to ensure transcriptome and proteome diversity reflecting their functional complexity.
Maria Apostolidi, Vassiliki Stamatopoulou   +1 more
doaj   +1 more source

RNA splicing analysis using heterogeneous and large RNA-seq datasets

Nature Communications, 2023
Here the authors develop MAJIQ v2 to address challenges in detection, quantification, and visualization of RNA splicing variations from large heterogeneous RNA-Seq datasets. They then apply it to analyze 2,335 samples from 13 brain subregions.
Jorge Vaquero-Garcia, Joseph K. Aicher, San Jewell, Matthew R. Gazzara, Caleb M. Radens, Anupama Jha, Scott Norton, N. Lahens, G. Grant, Yoseph Barash   +9 more
semanticscholar   +1 more source

Altered splicing of ATG16‐L1 mediates acquired resistance to tyrosine kinase inhibitors of EGFR by blocking autophagy in non‐small cell lung cancer

Molecular Oncology, 2022
Despite the initial efficacy of using tyrosine kinase inhibitors of epidermal growth factor receptors (EGFR‐TKIs) for treating patients with non‐small cell lung cancer (NSCLC), resistance inevitably develops.
Anne‐Sophie Hatat, Clara Benoit‐Pilven, Amélie Pucciarelli, Florence deFraipont, Lucie Lamothe, Pascal Perron, Amandine Rey, Matteo Giaj Levra, Anne‐Claire Toffart, Didier Auboeuf, Beatrice Eymin, Sylvie Gazzeri   +11 more
doaj   +1 more source