Results 11 to 20 of about 1,023,640 (307)
Dysregulation of RNA Splicing in Tauopathies [PDF]
Cell Reports, 2019 Summary: Pathological aggregation of RNA binding proteins (RBPs) is associated with dysregulation of RNA splicing in PS19 P301S tau transgenic mice and in Alzheimer’s disease brain tissues. The dysregulated splicing particularly affects genes involved in
Daniel J. Apicco +8 more
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RNA helicases in splicing [PDF]
RNA Biology, 2013 In eukaryotic cells, introns are spliced from pre-mRNAs by the spliceosome. Both the composition and the structure of the spliceosome are highly dynamic, and eight DExD/H RNA helicases play essential roles in controlling conformational rearrangements. There is evidence that the various helicases are functionally and physically connected with each other
Olivier, Cordin, Jean D, Beggs
openaire +2 more sources
Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism [PDF]
, 2010 For a long time it has been assumed that the decay of RNA in eukaryotes is mainly carried out by exoribonucleases, which is in contrast to bacteria, where endoribonucleases are well documented to initiate RNA degradation.
Tomecki, Rafał, Dziembowski, Andrzej
core +3 more sources
A splicing-dependent transcriptional checkpoint associated with prespliceosome formation [PDF]
, 2014 There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown.
Chathoth, Keerthi T +3 more
core +1 more source
Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development
Nature Communications, 2020 RNA editing and RNA splicing are involved in tumorigenesis. Here the authors report crosstalk between RNA editing and splicing by identifying ADAR1/2-dependent splicing events in esophageal squamous carcinoma cells.
Sze Jing Tang +13 more
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Mutations in the U5 snRNA result in altered splicing of subsets of pre-mRNAs and reduced stability of Prp8 [PDF]
, 2009 The U5 snRNA loop 1 aligns the 5' and 3' exons for ligation during the second step of pre-mRNA splicing. U5 is intimately associated with Prp8, which mediates pre-mRNA repositioning within the catalytic core of the spliceosome and interacts directly with
David Barrass, J. +5 more
core +1 more source
PLoS Biology, 2023 Fragile X syndrome (FXS) is a neurodevelopmental disorder that is often modeled in Fmr1 knockout mice where the RNA-binding protein FMRP is absent. Here, we show that in Fmr1-deficient mice, RNA mis-splicing occurs in several brain regions and peripheral
Suna Jung +3 more
doaj +1 more source
Spliced leader RNA trans-splicing in dinoflagellates [PDF]
Proceedings of the National Academy of Sciences, 2007 Through the analysis of hundreds of full-length cDNAs from fifteen species representing all major orders of dinoflagellates, we demonstrate that nuclear-encoded mRNAs in all species, from ancestral to derived lineages, are trans-spliced with the addition of the 22-nt conserved spliced leader (SL), DCCGUAGCCAUUUUGGCUCAAG (D = U, A, or G), to the 5′ end.
Huan, Zhang +6 more
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Computational prediction of splicing regulatory elements shared by Tetrapoda organisms [PDF]
, 2009 Background: auxiliary splicing sequences play an important role in ensuring accurate and efficient splicing by promoting or repressing recognition of authentic splice sites.
Churbanov, Alexander +8 more
core +1 more source
Global donor and acceptor splicing site kinetics in human cells
eLife, 2019 RNA splicing is an essential part of eukaryotic gene expression. Although the mechanism of splicing has been extensively studied in vitro, in vivo kinetics for the two-step splicing reaction remain poorly understood.
Leonhard Wachutka +3 more
doaj +1 more source