Results 11 to 20 of about 248,138 (311)

RNA splicing in bone diseases: mechanisms, pathogenesis and therapeutics [PDF]

Acta Biochimica Polonica
RNA splicing is a fundamental post-transcriptional mechanism that enables the generation of diverse mRNA isoforms from a single gene, thereby expanding proteomic complexity and regulating cell fate decisions.
Linlin Zheng, Hui Sun, Ning Li, Lianqing Wang, Tianchu Li, Qiaoli Zhai   +5 more
doaj   +2 more sources

RNA-Targeting Splicing Modifiers: Drug Development and Screening Assays

Molecules, 2021
RNA splicing is an essential step in producing mature messenger RNA (mRNA) and other RNA species. Harnessing RNA splicing modifiers as a new pharmacological modality is promising for the treatment of diseases caused by aberrant splicing.
Zhichao Tang, Junxing Zhao, Zach J. Pearson, Zarko V. Boskovic, Jingxin Wang   +4 more
doaj   +1 more source

Aberrant splicing in human cancer: An RNA structural code point of view

Frontiers in Pharmacology, 2023
Alternative splicing represents an essential process that occurs widely in eukaryotes. In humans, most genes undergo alternative splicing to ensure transcriptome and proteome diversity reflecting their functional complexity.
Maria Apostolidi, Vassiliki Stamatopoulou   +1 more
doaj   +1 more source

Altered splicing of ATG16‐L1 mediates acquired resistance to tyrosine kinase inhibitors of EGFR by blocking autophagy in non‐small cell lung cancer

Molecular Oncology, 2022
Despite the initial efficacy of using tyrosine kinase inhibitors of epidermal growth factor receptors (EGFR‐TKIs) for treating patients with non‐small cell lung cancer (NSCLC), resistance inevitably develops.
Anne‐Sophie Hatat, Clara Benoit‐Pilven, Amélie Pucciarelli, Florence deFraipont, Lucie Lamothe, Pascal Perron, Amandine Rey, Matteo Giaj Levra, Anne‐Claire Toffart, Didier Auboeuf, Beatrice Eymin, Sylvie Gazzeri   +11 more
doaj   +1 more source

Regulation of RNA Splicing: Aberrant Splicing Regulation and Therapeutic Targets in Cancer

Cells, 2021
RNA splicing is a critical step in the maturation of precursor mRNA (pre-mRNA) by removing introns and exons. The combination of inclusion and exclusion of introns and exons in pre-mRNA can generate vast diversity in mature mRNA from a limited number of ...
Koji Kitamura, Keisuke Nimura
doaj   +1 more source

RNA helicases in splicing [PDF]

RNA Biology, 2013
In eukaryotic cells, introns are spliced from pre-mRNAs by the spliceosome. Both the composition and the structure of the spliceosome are highly dynamic, and eight DExD/H RNA helicases play essential roles in controlling conformational rearrangements. There is evidence that the various helicases are functionally and physically connected with each other
Olivier, Cordin, Jean D, Beggs
openaire   +2 more sources

Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing

Nature Communications, 2022
Wiskott-Aldrich syndrome is caused by mutations in WASP, but the underlying mechanisms remain to be explored. Here the authors reveal that WASP deficiency results in aberrant RNA splicing, and that WASP regulates the transcription of splicing factor ...
Baolei Yuan, Xuan Zhou, Keiichiro Suzuki, Gerardo Ramos-Mandujano, Mengge Wang, Muhammad Tehseen, Lorena V. Cortés-Medina, James J. Moresco, Sarah Dunn, Reyna Hernandez-Benitez, Tomoaki Hishida, Na Young Kim, Manal M. Andijani, Chongwei Bi, Manching Ku, Yuta Takahashi, Jinna Xu, Jinsong Qiu, Ling Huang, Christopher Benner, Emi Aizawa, Jing Qu, Guang-Hui Liu, Zhongwei Li, Fei Yi, Yanal Ghosheh, Changwei Shao, Maxim Shokhirev, Patrizia Comoli, Francesco Frassoni, John R. Yates, Xiang-Dong Fu, Concepcion Rodriguez Esteban, Samir Hamdan, Mo Li, Juan Carlos Izpisua Belmonte   +35 more
doaj   +1 more source

Exploring RNA modifications, editing, and splicing changes in hyperuricemia and gout

Frontiers in Medicine, 2022
Hyperuricemia and gout are two of the most common metabolic disorders worldwide; their incidence is increasing with changes in lifestyle, and they are correlated with many diseases, including renal and cardiovascular diseases.
Chung-Ming Huang, Chung-Ming Huang, Chung-Ming Huang, Yu-Chia Chen, Yu-Chia Chen, Yu-Chia Chen, I-Lu Lai, I-Lu Lai, Hong-Da Chen, Po-Hao Huang, Siang-Jyun Tu, Ya-Ting Lee, Ya-Ting Lee, Ju-Chen Yen, Ju-Chen Yen, Chia-Li Lin, Chia-Li Lin, Ting-Yuan Liu, Ting-Yuan Liu, Ting-Yuan Liu, Jan-Gowth Chang, Jan-Gowth Chang   +21 more
doaj   +1 more source

Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development

Nature Communications, 2020
RNA editing and RNA splicing are involved in tumorigenesis. Here the authors report crosstalk between RNA editing and splicing by identifying ADAR1/2-dependent splicing events in esophageal squamous carcinoma cells.
Sze Jing Tang, Haoqing Shen, Omer An, HuiQi Hong, Jia Li, Yangyang Song, Jian Han, Daryl Jin Tai Tay, Vanessa Hui En Ng, Fernando Bellido Molias, Ka Wai Leong, Priyankaa Pitcheshwar, Henry Yang, Leilei Chen   +13 more
doaj   +1 more source

Genome-wide regulation of KSHV RNA splicing by viral RNA-binding protein ORF57.

PLoS Pathogens, 2022
RNA splicing plays an essential role in the expression of eukaryotic genes. We previously showed that KSHV ORF57 is a viral splicing factor promoting viral lytic gene expression.
Vladimir Majerciak, Beatriz Alvarado-Hernandez, Alexei Lobanov, Maggie Cam, Zhi-Ming Zheng   +4 more
doaj   +1 more source