Results 11 to 20 of about 1,489,947 (420)
Aberrant splicing in human cancer: An RNA structural code point of view
Frontiers in Pharmacology, 2023 Alternative splicing represents an essential process that occurs widely in eukaryotes. In humans, most genes undergo alternative splicing to ensure transcriptome and proteome diversity reflecting their functional complexity.
Maria Apostolidi +1 more
doaj +1 more source
RNA-Targeting Splicing Modifiers: Drug Development and Screening Assays
Molecules, 2021 RNA splicing is an essential step in producing mature messenger RNA (mRNA) and other RNA species. Harnessing RNA splicing modifiers as a new pharmacological modality is promising for the treatment of diseases caused by aberrant splicing.
Zhichao Tang +4 more
doaj +1 more source
RNA splicing analysis using heterogeneous and large RNA-seq datasets
Nature Communications, 2023 Here the authors develop MAJIQ v2 to address challenges in detection, quantification, and visualization of RNA splicing variations from large heterogeneous RNA-Seq datasets. They then apply it to analyze 2,335 samples from 13 brain subregions.
Jorge Vaquero-Garcia +9 more
semanticscholar +1 more source
Molecular Oncology, 2022 Despite the initial efficacy of using tyrosine kinase inhibitors of epidermal growth factor receptors (EGFR‐TKIs) for treating patients with non‐small cell lung cancer (NSCLC), resistance inevitably develops.
Anne‐Sophie Hatat +11 more
doaj +1 more source
Nature Communications, 2022 Neuroblastoma is the most common paediatric solid tumour and prognosis remains poor for high-risk cases despite the use of multimodal treatment. Analysis of public drug sensitivity data showed neuroblastoma lines to be sensitive to indisulam, a molecular
A. Nijhuis +21 more
semanticscholar +1 more source
Predicting RNA splicing from DNA sequence using Pangolin
Genome Biology, 2021 Recent progress in deep learning has greatly improved the prediction of RNA splicing from DNA sequence. Here, we present Pangolin, a deep learning model to predict splice site strength in multiple tissues.
Tony Zeng, Yang I. Li
semanticscholar +1 more source
Science, 2015 A model predicts the impact of variations in the human genome on RNA splicing and disease [Also see Research Article by Xiong et al. ]
Guigó Serra, Roderic +1 more
openaire +4 more sources
Signal Transduction and Targeted Therapy, 2022 Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression, yet how this process is regulated by oncogenic signal remains largely unknown.
Sisi Li +30 more
semanticscholar +1 more source
Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing
Nature Communications, 2022 Wiskott-Aldrich syndrome is caused by mutations in WASP, but the underlying mechanisms remain to be explored. Here the authors reveal that WASP deficiency results in aberrant RNA splicing, and that WASP regulates the transcription of splicing factor ...
Baolei Yuan +35 more
doaj +1 more source
Exploring RNA modifications, editing, and splicing changes in hyperuricemia and gout
Frontiers in Medicine, 2022 Hyperuricemia and gout are two of the most common metabolic disorders worldwide; their incidence is increasing with changes in lifestyle, and they are correlated with many diseases, including renal and cardiovascular diseases.
Chung-Ming Huang +21 more
doaj +1 more source