Results 11 to 20 of about 1,384,640 (333)
Dysregulation of RNA Splicing in Tauopathies [PDF]
Cell Reports, 2019 Summary: Pathological aggregation of RNA binding proteins (RBPs) is associated with dysregulation of RNA splicing in PS19 P301S tau transgenic mice and in Alzheimer’s disease brain tissues. The dysregulated splicing particularly affects genes involved in
Daniel J. Apicco +8 more
doaj +3 more sources
Aberrant RNA Splicing in Cancer. [PDF]
Annual Review of Cancer Biology, 2019 RNA splicing, the enzymatic process of removing segments of premature RNA to produce mature RNA, is a key mediator of proteome diversity and regulator of gene expression.
Luisa F. Escobar-Hoyos +2 more
semanticscholar +3 more sources
bioRxiv, 2023 RNA splicing is an important post-transcriptional process of gene expression in eukaryotic cells. Predicting RNA splicing from primary sequences can facilitate the interpretation of genomic variants.
Ken Chen +5 more
semanticscholar +1 more source
Predicting RNA splicing from DNA sequence using Pangolin
Genome Biology, 2021 Recent progress in deep learning has greatly improved the prediction of RNA splicing from DNA sequence. Here, we present Pangolin, a deep learning model to predict splice site strength in multiple tissues.
Tony Zeng, Yang I. Li
semanticscholar +1 more source
Therapeutic Targeting of RNA Splicing in Cancer
Genes, 2023 RNA splicing is a key regulatory step in the proper control of gene expression. It is a highly dynamic process orchestrated by the spliceosome, a macro-molecular machinery that consists of protein and RNA components. The dysregulation of RNA splicing has
Elizabeth A. Bonner, Stanley C Lee
semanticscholar +1 more source
RNA helicases in splicing [PDF]
RNA Biology, 2013 In eukaryotic cells, introns are spliced from pre-mRNAs by the spliceosome. Both the composition and the structure of the spliceosome are highly dynamic, and eight DExD/H RNA helicases play essential roles in controlling conformational rearrangements. There is evidence that the various helicases are functionally and physically connected with each other
Olivier, Cordin, Jean D, Beggs
openaire +2 more sources
Exploring RNA modifications, editing, and splicing changes in hyperuricemia and gout
Frontiers in Medicine, 2022 Hyperuricemia and gout are two of the most common metabolic disorders worldwide; their incidence is increasing with changes in lifestyle, and they are correlated with many diseases, including renal and cardiovascular diseases.
Chung-Ming Huang +21 more
doaj +1 more source
Nature Communications, 2022 Neuroblastoma is the most common paediatric solid tumour and prognosis remains poor for high-risk cases despite the use of multimodal treatment. Analysis of public drug sensitivity data showed neuroblastoma lines to be sensitive to indisulam, a molecular
A. Nijhuis +21 more
semanticscholar +1 more source
Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing
Nature Communications, 2022 Wiskott-Aldrich syndrome is caused by mutations in WASP, but the underlying mechanisms remain to be explored. Here the authors reveal that WASP deficiency results in aberrant RNA splicing, and that WASP regulates the transcription of splicing factor ...
Baolei Yuan +35 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2022 Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression, yet how this process is regulated by oncogenic signal remains largely unknown.
Sisi Li +30 more
semanticscholar +1 more source