Results 231 to 240 of about 1,500,138 (355)

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

open access: yesAdvanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo   +10 more
wiley   +1 more source

Comprehensive analysis of the circular RNA expression profile and circRNA–miRNA–mRNA network in the goat skin with divergent wool curvature

open access: yesAnimal Research and One Health, EarlyView., 2023
In our study, we conducted circRNA expression profiling of Zhongwei goat skin exhibiting divergent curvature wool phenotypes at two developmental stages using the RNA‐seq. Functional verification assay demonstrated that circRNA8782 regulated fibroblast proliferation.
Yingxiao Su   +9 more
wiley   +1 more source

Regulation of Postnatal Cardiomyocyte Maturation by an RNA Splicing Regulator RBFox1. [PDF]

open access: yesCirculation, 2023
Huang J   +21 more
europepmc   +1 more source

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

open access: yesAdvanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen   +11 more
wiley   +1 more source

Identified five variants in CFTR gene that alter RNA splicing by minigene assay. [PDF]

open access: yesFront Genet
Zhang B   +8 more
europepmc   +1 more source

Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells

open access: yesAdvanced Science, EarlyView.
Engineered through structure‐guided protein engineering, enCas12j‐8 significantly enhances the editing efficiency of compact Cas12j‐8 while maintaining high specificity. It enables efficient multiplexed genome editing and base editing using a single crRNA array, demonstrating broad applicability and therapeutic potential in genome engineering ...
Ru Meng   +14 more
wiley   +1 more source

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