Mutations in U1 snRNA bypass the requirement for a cell type-specific RNA splicing factor
Krishnan Nandabalan+2 more
openalex +1 more source
PRMT1 inhibitor MS023 suppresses RNA splicing to sensitize small cell lung cancer to DNA damaging agents. [PDF]
Aparnathi MK+17 more
europepmc +1 more source
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen+11 more
wiley +1 more source
RNA Binding Activity of Heterodimeric Splicing Factor U2AF: at Least One RS Domain Is Required for High-Affinity Binding [PDF]
David Z. Rudner+4 more
openalex +1 more source
Genetic modulation of RNA splicing rescues BRCA2 function in mutant cells. [PDF]
Lima BA+7 more
europepmc +1 more source
Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells
Engineered through structure‐guided protein engineering, enCas12j‐8 significantly enhances the editing efficiency of compact Cas12j‐8 while maintaining high specificity. It enables efficient multiplexed genome editing and base editing using a single crRNA array, demonstrating broad applicability and therapeutic potential in genome engineering ...
Ru Meng+14 more
wiley +1 more source
Control of Human Immunodeficiency Virus Type 1 RNA Metabolism: Role of Splice Sites and Intron Sequences in Unspliced Viral RNA Subcellular Distribution [PDF]
Béatrice Séguin+2 more
openalex +1 more source
The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis. [PDF]
Meng K+13 more
europepmc +1 more source
Single‐cell RNA sequencing identifies MMP11⁺ CAFs as pro‐angiogenic cells accumulating during bladder cancer progression. These cells promote angiogenesis by regulating ESM1⁺ tip endothelial cells and recruiting SPP1⁺ macrophages. Tumor‐derived BMP2 promotes their activation.
Wuwu Xu+13 more
wiley +1 more source
Regulation of human insulin receptor RNA splicing invivo.
Svante Norgren+4 more
openalex +1 more source