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Trends in Cancer, 2020
RNA splicing is an essential process that governs many aspects of cellular proliferation, survival, and differentiation. Considering the importance of RNA splicing in gene regulation, alterations in this pathway have been implicated in many human cancers.
Eric, Wang, Iannis, Aifantis
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RNA splicing is an essential process that governs many aspects of cellular proliferation, survival, and differentiation. Considering the importance of RNA splicing in gene regulation, alterations in this pathway have been implicated in many human cancers.
Eric, Wang, Iannis, Aifantis
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1992
RNA trans-splicing joins two or more RNA molecules into one RNA molecule. This process is a variation of the more familiar and common intron removal during nuclear pre-mRNA splicing. Both splicing reactions are a series of cleavage and ligation reactions resulting in the precise excision of introns and in the joining of exons to generate mature RNA. In
X Y, Huang, D, Hirsh
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RNA trans-splicing joins two or more RNA molecules into one RNA molecule. This process is a variation of the more familiar and common intron removal during nuclear pre-mRNA splicing. Both splicing reactions are a series of cleavage and ligation reactions resulting in the precise excision of introns and in the joining of exons to generate mature RNA. In
X Y, Huang, D, Hirsh
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DNA-catalysed alternative RNA splicing
Chemical Communications, 2022DNA can catalyse alternative RNA splicing reactionsin vitro, and modulate RNA structure and function.
Dongying Wei +6 more
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2018
Circular RNAs (circRNAs) are covalently closed single-stranded RNA molecules derived from exons by alternative mRNA splicing. Circularization of single-stranded RNA molecules was already described in 1976 for viroids in plants. Since then several additional types of circular RNAs in many species have been described such as the circular single-stranded ...
Nicole, Eger +4 more
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Circular RNAs (circRNAs) are covalently closed single-stranded RNA molecules derived from exons by alternative mRNA splicing. Circularization of single-stranded RNA molecules was already described in 1976 for viroids in plants. Since then several additional types of circular RNAs in many species have been described such as the circular single-stranded ...
Nicole, Eger +4 more
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JAMA: The Journal of the American Medical Association, 1988
The splicing of long transcripts of RNA (copied from DNA in the cell nucleus) into smaller, specific mRNA (ready for export to the protein-producing machinery in the cytoplasm) is an important event in the regulation of gene expression in eukaryotic cells. The splicing reaction occurs as a late step in the nuclear pathway for synthesis of mRNAs.
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The splicing of long transcripts of RNA (copied from DNA in the cell nucleus) into smaller, specific mRNA (ready for export to the protein-producing machinery in the cytoplasm) is an important event in the regulation of gene expression in eukaryotic cells. The splicing reaction occurs as a late step in the nuclear pathway for synthesis of mRNAs.
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Spliced leader RNA trans-splicing in metazoa
Parasitology Today, 1996Spliced leader trans-splicing is a form of RNA processing originally described and studied in parasitic kinetoplastida. This mechanism of gene expression also occurs in parasitic and free-living metazoa. In this review, Dick Davis describes current knowledge of the distribution, substrates, specificity and functional significance of trans-splicing in ...
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RNA splicing promotes translation and RNA surveillance
Nature Structural & Molecular Biology, 2005Aberrant mRNAs harboring premature termination codons (PTCs or nonsense codons) are degraded by the nonsense-mediated mRNA decay (NMD) pathway. mRNAs transcribed from genes that naturally acquire PTCs during lymphocyte development are strongly downregulated by PTCs.
Jayanthi P, Gudikote +3 more
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RNA splicing in lower eukaryotes
Current Biology, 1992Recently, cis-acting elements and trans-acting RNA and protein factors necessary for splicing nuclear pre-mRNAs, group II introns or group III introns, have been discovered, and new roles for the splicing factors have been elucidated. Parallels among the pathways for splicing these different classes of introns have been identified.
J L, Woolford, C L, Peebles
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