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Visualizing RNA splicing in vivo
Molecular BioSystems, 2007Ribozymes are RNA molecules capable of associating with other RNA molecules through base-pairing and catalyzing various reactions involving phosphate group transfer. Of particular interest to us is the well known ribozyme from Tetrahymena thermophila capable of catalyzing RNA splicing in eukaryotic systems, chiefly because of its potential use as a ...
Gayatri, Gowrishankar, Jianghong, Rao
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Circulation Research, 2016
RNA splicing represents a post-transcriptional mechanism to generate multiple functional RNAs or proteins from a single transcript. The evolution of RNA splicing is a prime example of the Darwinian function follows form concept. A mutation that leads to a new mRNA (form) that encodes for a new functional protein (function) is likely to be retained, and
Maarten M G, van den Hoogenhof +2 more
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RNA splicing represents a post-transcriptional mechanism to generate multiple functional RNAs or proteins from a single transcript. The evolution of RNA splicing is a prime example of the Darwinian function follows form concept. A mutation that leads to a new mRNA (form) that encodes for a new functional protein (function) is likely to be retained, and
Maarten M G, van den Hoogenhof +2 more
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Splicing of Messenger RNA Precursors
Science, 1987A general mechanism for the splicing of nuclear messenger RNA precursors in eukaryotic cells has been widely accepted. This mechanism, which generates lariat RNAs possessing a branch site, seems related to the RNA-catalyzed reactions of self-splicing introns.
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RNA splicing dysregulation and the hallmarks of cancer
Nature Reviews Cancer, 2023Robert K Bradley, Olga Anczukow
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The physiology of alternative splicing
Nature Reviews Molecular Cell Biology, 2022Alberto Kornblihtt
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From trans-splicing discovery and onwards, trypanosomes lead the way
Nature Reviews Molecular Cell Biology, 2022Idálio J Viegas, Luisa Figueiredo
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Pharmacologic modulation of RNA splicing enhances anti-tumor immunity
Cell, 2021Richard E Taylor +2 more
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