Results 271 to 280 of about 211,496 (309)

RNA Splicing and Genes

JAMA: The Journal of the American Medical Association, 1988
The splicing of long transcripts of RNA (copied from DNA in the cell nucleus) into smaller, specific mRNA (ready for export to the protein-producing machinery in the cytoplasm) is an important event in the regulation of gene expression in eukaryotic cells. The splicing reaction occurs as a late step in the nuclear pathway for synthesis of mRNAs.
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RNA Splicing in the Chloroplast

2006
The chloroplast genomes of Chlamydomonas spp. contain introns that belong to the two major classes found in organelles: group I and group II. Some of the members of both classes are ribozymes capable of self-splicing in vitro and, indeed, most of the group I introns studied in Chlamydomonas spp. are autocatalyic.
Herrin, David L., Kuo, Tai-Chih, Goldschmidt-Clermont, Michel P.   +2 more
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Splicing in the RNA World

2012
Alternative splicing is a key element of eukaryotic gene expression. Almost all polymerase II transcripts are alternatively spliced. RNA is chemically and structurally more flexible than DNA, and can act as a catalyst. RNA is an active player in mediating genetic information, not just a static messenger.
BURATTI, EMANUELE, ROMANO, MAURIZIO, BARALLE F. E.   +2 more
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RNA splicing in lower eukaryotes

Current Biology, 1992
Recently, cis-acting elements and trans-acting RNA and protein factors necessary for splicing nuclear pre-mRNAs, group II introns or group III introns, have been discovered, and new roles for the splicing factors have been elucidated. Parallels among the pathways for splicing these different classes of introns have been identified.
John L. Woolford, Craig L. Peebles, Craig L. Peebles   +2 more
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Spliced leader RNA trans-splicing in metazoa

Parasitology Today, 1996
Spliced leader trans-splicing is a form of RNA processing originally described and studied in parasitic kinetoplastida. This mechanism of gene expression also occurs in parasitic and free-living metazoa. In this review, Dick Davis describes current knowledge of the distribution, substrates, specificity and functional significance of trans-splicing in ...
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Visualizing RNA splicing in vivo

Molecular BioSystems, 2007
Ribozymes are RNA molecules capable of associating with other RNA molecules through base-pairing and catalyzing various reactions involving phosphate group transfer. Of particular interest to us is the well known ribozyme from Tetrahymena thermophila capable of catalyzing RNA splicing in eukaryotic systems, chiefly because of its potential use as a ...
Gayatri Gowrishankar, Jianghong Rao
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RNA Splicing: Activity in the spliceosome

Current Biology, 1994
In the active spliceosome, U2, U5 and U6 small nuclear RNAs form a network of interactions with the RNA substrate. U6 snRNA is closely implicated in the catalysis of splicing.
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RNA Trans-Splicing for Genodermatoses

2012
Spliceosome-mediated RNA trans-splicing (SMaRT) is a tool that facilitates the recombination of two distinct pre-mRNA molecules. Its application for gene therapeutic purposes has been hindered by laborious procedures to identify gene-specific molecules.
Ulrich Koller, Johann W. Bauer, Verena Wally, Eva M. Murauer   +3 more
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RNA Splicing

2013
Roca, X., Krainer, A. R.
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Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing

Cell, 2021
Kamila Delaney, Radha Raman Pandey, Kuan-ming Chen   +2 more
exaly