Results 51 to 60 of about 154,659 (331)
A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. [PDF]
, 2015 The kinase/endonuclease IRE1 is the most conserved signal transducer of the unfolded protein response (UPR), an intracellular signaling network that monitors and regulates the protein folding capacity of the endoplasmic reticulum (ER).
Acosta-Alvear, Diego +3 more
core +1 more source
RNA-Seq analysis of splicing in Plasmodium falciparum uncovers new splice junctions, alternative splicing and splicing of antisense transcripts. [PDF]
, 2011 Over 50% of genes in Plasmodium falciparum, the deadliest human malaria parasite, contain predicted introns, yet experimental characterization of splicing in this organism remains incomplete.
DeRisi, Joseph L +2 more
core +3 more sources
Intronic noncoding RNAs and splicing
Trends in Plant Science, 2008 The gene organization of small nucleolar RNAs (snoRNAs) and microRNAs (miRNAs) varies within and among different organisms. This diversity is reflected in the maturation pathways of these small noncoding RNAs (ncRNAs). The presence of noncoding RNAs in introns has implications for the biogenesis of both mature small RNAs and host mRNA.
Brown, John W. S. +2 more
openaire +6 more sources
Biology, 2016 Group I self-splicing intron constitutes an important class of functional RNA molecules that can promote chemical transformation. Although the fundamental mechanism of the auto-excision from its precursor RNA has been established, convenient assay ...
Airi Furukawa +4 more
doaj +1 more source
Catalytic RNA and RNA Splicing [PDF]
American Zoologist, 1989 The capacity of Watson-Crick base-pair complementarity to direct informational transactions basic to gene expression has long been appreciated. Among RNA molecules, it mediates mRNA-tRNA codon-anticodon pairing and the 16S rRNA-mRNA Shine-Dalgarno interaction.
openaire +2 more sources
Integrating splice-isoform expression into genome-scale models characterizes breast cancer metabolism [PDF]
Bioinformatics, btx562, 34(3):494-501, 2018, 2018 Motivation: Despite being often perceived as the main contributors to cell fate and physiology, genes alone cannot predict cellular phenotype. During the process of gene expression, 95% of human genes can code for multiple proteins due to alternative splicing.
arxiv +1 more source
Molecular Therapy: Nucleic Acids, 2017 Antiviral strategies targeting hijacked cellular processes are less easily evaded by the virus than viral targets. If selective for viral functions, they can have a high therapeutic index.
Carin K. Ingemarsdotter +4 more
doaj +1 more source
De novo prediction of PTBP1 binding and splicing targets reveals unexpected features of its RNA recognition and function. [PDF]
, 2014 The splicing regulator Polypyrimidine Tract Binding Protein (PTBP1) has four RNA binding domains that each binds a short pyrimidine element, allowing recognition of diverse pyrimidine-rich sequences.
Black, Douglas L +5 more
core +3 more sources
RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer [PDF]
, 2022 Tumour cell plasticity is a major barrier to the efficacy of targeted cancer therapies but the mechanisms that mediate it are poorly understood. Here, we identify dysregulated RNA splicing as a key driver of tumour cell dedifferentiation in colorectal ...
Adams, Ian R. +17 more
core +2 more sources
Identifying RNA splicing factors using IFT genes in Chlamydomonas reinhardtii [PDF]
Open Biology, 2018 Intraflagellar transport moves proteins in and out of flagella/cilia and it is essential for the assembly of these organelles. Using whole-genome sequencing, we identified splice site mutations in two IFT genes, IFT81 (fla9) and IFT121 (ift121-2), which ...
Huawen Lin +3 more
doaj +1 more source