Results 51 to 60 of about 219,883 (262)

Aberrant RNA Splicing in Cancer [PDF]

Annual Review of Cancer Biology, 2019
RNA splicing, the enzymatic process of removing segments of premature RNA to produce mature RNA, is a key mediator of proteome diversity and regulator of gene expression. Increased systematic sequencing of the genome and transcriptome of cancers has identified a variety of means by which RNA splicing is altered in cancer relative to normal cells ...
Luisa, Escobar-Hoyos, Katherine, Knorr, Omar, Abdel-Wahab   +2 more
openaire   +2 more sources

Chromatin target of protein arginine methyltransferases alleviates cerebral ischemia/reperfusion-induced injury by regulating RNA alternative splicing

iScience
Summary: RNA splicing is a post-transcriptional event that regulates many physiological and pathological events. However, whether RNA splicing regulates cerebral I/R-induced brain injury remains largely unknown. In this study, we found that the chromatin
Yu Cui, Zhaolong Zhang, Mengfei Lv, Zhongying Duan, Wenhao Liu, Jingchen Gao, Rui Xu, Qi Wan   +7 more
doaj   +1 more source

The Conserved RNA Binding Cyclophilin, Rct1, Regulates Small RNA Biogenesis and Splicing Independent of Heterochromatin Assembly

Cell Reports, 2017
Summary: RNAi factors and their catalytic activities are essential for heterochromatin assembly in S. pombe. This has led to the idea that siRNAs can promote H3K9 methylation by recruiting the cryptic loci regulator complex (CLRC), also known as ...
An-Yun Chang, Stephane E. Castel, Evan Ernst, Hyun Soo Kim, Robert A. Martienssen   +4 more
doaj   +1 more source

HIV-1: To Splice or Not to Splice, That Is the Question

Viruses, 2021
The transcription of the HIV-1 provirus results in only one type of transcript—full length genomic RNA. To make the mRNA transcripts for the accessory proteins Tat and Rev, the genomic RNA must completely splice.
Ann Emery, Ronald Swanstrom
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

HIV RNA splicing

HIV & AIDS Review, 2011
Abstract RNA splicing is one of the most important events of pre-RNA maturation. Pre-RNA transcript may be spliced in several different ways, allowing a single viral gene to encode multiple proteins. The retroviral life cycle requires that significant amounts of RNA remain unspliced and perform many function in the cytoplasm.
Katarzyna Hryckiewicz, Maciej Bura, Arleta Kowala-Piaskowska, Beata Bolewska, Iwona Mozer-Lisewska   +4 more
openaire   +1 more source

RNA splicing: disease and therapy [PDF]

Briefings in Functional Genomics, 2011
The majority of human genes that encode proteins undergo alternative pre-mRNA splicing and mutations that affect splicing are more prevalent than previously thought. The mechanism of pre-mRNA splicing is highly complex, requiring multiple interactions between pre-mRNA, small nuclear ribonucleoproteins and splicing factor proteins.
Douglas, Andrew G.L., Wood, Matthew J.A.
openaire   +4 more sources

RBM17 Interacts with U2SURP and CHERP to Regulate Expression and Splicing of RNA-Processing Proteins

Cell Reports, 2018
Summary: RNA splicing entails the coordinated interaction of more than 150 proteins in the spliceosome, one of the most complex of the cell’s molecular machines.
Antonia De Maio, Hari Krishna Yalamanchili, Carolyn J. Adamski, Vincenzo A. Gennarino, Zhandong Liu, Jun Qin, Sung Y. Jung, Ronald Richman, Harry Orr, Huda Y. Zoghbi   +9 more
doaj   +1 more source

AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing

Nature Communications, 2021
IWS1 regulates multiple steps in RNA metabolism, including RNA elongation and alternative RNA splicing. Here the authors show that AKT3 phosphorylates IWS1, which alters U2AF2 RNA splicing and promotes growth of lung adenocarcinomas via a Sororin/ERK ...
Georgios I. Laliotis, Evangelia Chavdoula, Maria D. Paraskevopoulou, Abdul Kaba, Alessandro La Ferlita, Satishkumar Singh, Vollter Anastas, Keith A. Nair, Arturo Orlacchio, Vasiliki Taraslia, Ioannis Vlachos, Marina Capece, Artemis Hatzigeorgiou, Dario Palmieri, Christos Tsatsanis, Salvatore Alaimo, Lalit Sehgal, David P. Carbone, Vincenzo Coppola, Philip N. Tsichlis   +19 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source